Journal List > J Nutr Health > v.52(2) > 1122026

J Nutr Health. 2019 Apr;52(2):149-156. Korean.
Published online Apr 30, 2019.  https://doi.org/10.4163/jnh.2019.52.2.149
© 2019 The Korean Nutrition Society
Dietary effect of Lactobacillus plantarum CJLP55 isolated from kimchi on skin pH and its related biomarker levels in adult subjects
Sangshin Han,1 Jihye Shin,1 Sunhee Lim,1 Hee Yoon Ahn,2 Bongjoon Kim,2 and Yunhi Cho1
1Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Gyeonggi 17104, Korea.
2CJ Foods R&D Center, CJ CheilJedang Corporation, Suwon, Gyeongggi 16495, Korea.

To whom correspondence should be addressed. tel: +82-31-201-3817, Email: choyunhi@khu.ac.kr
Received Dec 10, 2018; Revised Feb 14, 2019; Accepted Feb 14, 2019.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Purpose

The skin pH is maintained by epidermal lactate, free fatty acids (FFAs), and free amino acids (FAAs). As a significant determinant of skin health, the skin pH is increased (less acidic) under abnormal and aged skin conditions. In a search for dietary alternatives that would promote an acidic skin pH, this study investigated the dietary effects of Lactobacillus plantarum CJLP55 isolated from Korean kimchi on the skin pH, and epidermal levels of lactate, FFAs, and FAAs in adult subjects.

Methods

Seventy eight subjects (mean age 24.9 ± 0.5 years, range 19 ~ 37 years) were assigned randomly to ingest CJLP55, Lactobacillus strain from kimchi, (n = 39, CJLP group) or placebo supplements (n = 39, placebo group) for 12 weeks in a double-blind, placebo-controlled trial. Skin pH and epidermal levels of lactate, FFAs and FFAs were assessed at 0, 6 and 12 weeks.

Results

Although significant decreases in skin pH were observed in both the CJLP and placebo groups at 6 weeks, the skin pH was decreased significantly only in the CJLP group at 12 weeks. In parallel, the epidermal level of lactate in the CJLP group was also increased by 25.6% at 12 weeks. On the other hand, the epidermal level of FAAs were not altered in the CJLP and placebo groups, but the epidermal level of total FFAs, including palmitic acid and stearic acid, was lower in the CJLP group than in the placebo group over 12 weeks. The changes in the other FFAs, such as palmitoleic acid and oleic acid, were similar in the CJLP and placebo groups over 12 weeks.

Conclusion

Overall, a dietary supplement of CJLP55 promotes acidic skin pH with a selective increase in epidermal lactate in adult subjects.

Keywords: skin pH; Lactobacillus plantarum; lactate; free amino acid; free fatty acid

Figures


Fig. 1
Altered skin pH in groups. Skin surface pH was measured by skin pH meter. All values are means ± SEM (n = 39 / group). Differences from 0 week within CJLP or Placebo groups were evaluated by Student's paired t-test (*p < 0.05, **p < 0.01, ***p < 0.001). Differences between CJLP and Placebo groups were evaluated by Student's unpaired t-test (#p < 0.05).
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Fig. 2
Altered free fatty acid (FFA) levels in the skin surface of groups. Individual FFA was fractionated by high-performance thin-layer chromatography, eluted, and further analyzed by gas chromatography after acid methanolysis. All values are mean ± SEM (n = 39 / group). Differences from 0 week within CJLP or Placebo groups were evaluated by paired Student's t-test (*p < 0.05, **p < 0.01, ***p < 0.001). Differences between CJLP and Placebo groups were evaluated by unpaired Student's t-test (#p < 0.05).
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Tables


Table 1
Altered lactate levels in the skin surface of groups
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Table 2
Altered free amino levels in the skin surface of groups
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Notes

This study was supported by a grant from CJ Foods R&D Center, CJ CheilJedang Corporation in Suwon-si, Gyeongggi-do, Republic of Korea (KHU grant No. 20150943).

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