Image Evaluation Via SUVLBM for Normal Regions of VOI by Using Whole Body Images Obtained from PET/MRI and PET/CT

Jeong Kyu Park; Sung Kyu Kim; Ihn Ho Cho; Eun Jung Kong; Meyong Hwan Park

doi:10.14316/pmp.2013.24.1.68

Journal List > Prog Med Phys > v.24(1) > 1098412

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Park, Kim, Cho, Kong, and Park: Image Evaluation Via SUVLBM for Normal Regions of VOI by Using Whole Body Images Obtained from PET/MRI and PET/CT

Original Article

Progress in Medical Physics 2013;24(1):68-75.

Published online: 20 March 2013

DOI: https://doi.org/10.14316/pmp.2013.24.1.68

Image Evaluation Via SUV_LBM for Normal Regions of VOI by Using Whole Body Images Obtained from PET/MRI and PET/CT

Jeong Kyu Park^∗, Sung Kyu Kim^†,, Ihn Ho Cho^‡, Eun Jung Kong^‡, Meyong Hwan Park^∗

^∗Department of Radiologic Technology, Daegu Health College, Daegu, Korea

^†Department of Therapeutic Radiology & Oncology, Daegu, Korea

^‡Department of Nuclear Medicine, Yeungnam University College of Medicine, Daegu, Korea

책임저자：김성규, (705-717) 대구시 남구 대명동 317-1 영남대학교 의과대학 방사선종학교실 Tel: 053)620-3373, Fax: 053)624-3599 E-mail: skkim3@ynu.ac.kr

Received 18 February 2013 Accepted 5 March 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this research is to compare and analyze SUV_LBM-maximum of normal regions using VOI (the volume of interest) in order to enhance the diagnostic level in whole body images of PET/CT and PET/MRI for 26 health check-up participants. In particular, we try to set up SUV_LBM-maximum data that can be used in synchronous evaluation for PET/CT and PET/MRI without contrast media. The evaluation of SUV_LBM-maximum for normal regions of whole body PET/CT and whole body PET/MRI shows that the image of PET/MRI differs very significantly from the reference image of PET/CT (p＜0.0001). However, they exhibit high correlations in view of statistics (R＞0.8). From this research, we suggest that the decision in the evaluation of SUV_LBM-maximum for PET/MRI should be made with the reduction of about 26.3%, while one should decide with the reduction of about 29.3% when the contrast media is used. It is helpful to interpret all image of PET/CT and PET/MRI using SUV_LBM-maximum for convenience and efficiency.

Keywords: PET/CT, PET/MRI, Volume of interest, Normal regions, SUV_LBM-maximum

References

1. Antoch G, Bockisch A. Combined PET/MRI: a new dimension inwhole-body oncology imaging? Eur J Nucl Med Mol Imaging. 36:113–120. 2009.

2. Antoch G, Vogt FM, Freudenberg LS, et al. Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology. JAMA. 290:3199–3206. 2003.

3. Beer AJ, Eiber M, Souvatzoglou M, Schwaiger M, Krause BJ. Radionuclide and hybrid imaging of recurrent prostate cancer. Lancet Oncology. 12:181–191. 2011.

4. Kinahan PE, Hasegawa BH, Beyer T. X-ray-based attenuation correction for positron emission tomography/computed tomography scanners. Semin Nucl Med. 33:166–179. 2003.

5. Zaidi H. Is MRI-guided attenuation correction a viable option for dual modality PET/MRI imaging? Radiology. 244:639–642. 2007.

6. Martinez-Möller A, Souvatzoglou M, Delso G, et al. Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI: evaluation with PET/CT data. J Nucl Med. 50:520–526. 2009.

7. Zincirkeser S, Sahin E, Halac M, Sager S. Standardized uptake values of normal organs on 18F-Fluorodeoxyglucose positron emission tomography and computed tomography imaging. J Int Med Res. 35:231–236. 2007.

8. Boellaard R. Standards for PET image acquisition and quantitative data analysis. J Nucl Med. 50:11–20. 2009.

9. Hong SL. A study for distortion of standardized uptake value according to the does and lesion size using 18F-FDG PET/CT. Graduates school Korea Univ, Seoul, Korea (. 2012.

10. Menda Y, Bushnell DL, Madsen MT, McLaughlin K, Kahn D, Kernstine KH. Evaluation of various corrections to the standardized uptake value for diagnosis of pulmonary malignancy. Nucl Med Common. 22:1077–1081. 2001.

11. Zasadny KR, Wahl RL. Standardized uptake values of normal tissues at PET with2-[fluorine-18]-fluoro-2-deoxy-D-glucose: variations with body weight and a method for correction. Radiology. 189:847–850. 1993.

12. Wahl RL, Jacene H, Kasamon Y, Lodge MA. From RECIST to PERCIST: Evolving Considerations for PET response criteria in solid tumors. J Nucl Med 50 Suppl. 1:122S–150S. 2009.

13. Matthias E, Axel MM, Michael S, et al. Value of a dixon-based MRI/PET attenuation correction sequence for the localization and evaluation of PET-positive lesions. Eur J Nucl Med Mol Imaging. 38:1691–1701. 2011.

14. Katrine Å: PET/CT: nuclear medicine imaging in the future. Radiation Protection Dosimetry. 139:8–11. 2010.

15. Hofmann M, Steinke F, Scheel V, et al. MRI-based attenuation correction for PET/MRI: a novel approach combining pattern recognition and atlas registration. J Nucl Med. 49:1875–1883. 2008.

16. Schulz V, Torres-Espallardo I, Renisch S, et al. Automatic, three-segment, MRI-based attenuation correction for whole-body PET/MRI data. Eur J Nucl Med Mol Imaging. 38:138–152. 2011.

17. Boellaard R, O'Doherty MJ, Weber WA, et al. FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0. Eur J Nucl Med Mol Imaging. 37:181–200. 2010.

18. Lauenstein TC, Semelka RC. Emerging techniques: whole body screening and staging with MRI. J Magn Reson Imaging. 24:489–498. 2006.

19. Castelijns JA, van den Brekel MWM. Imaging of lymphadenopathy in the neck. Eur Radiology. 12:727–738. 2002.

20. Kim WP. Statistical analysis lecture fundamentals. Statistics & Society. 90:97–289. 2007.

Fig. 1.

(a∼c) SUVs measurements confirm anatomical location in the PET/CT coronal, sagittal, and transverse images, (d∼f) SUVs measurements confirm anatomical location in the PET/MRI coronal, sagittal, and transverse images.

Fig. 2.

According to non-contrast media or contrast media used, SUV_LBM-maximum normal volumes corresponding.

Table 1.

Comparison of PET/CT SUV_LBM-maximum and PET/MRI SUV_LBM-maximum.

	PET/CT SUV_LBM-maximum (2.13±0.26)				PET/MRI SUV_LBM-maximum (1.58±0.29)
p				0.001
R				0.873
N		10			10
Model	Unstandardized coefficients		Standardized coefficients	t	p	95% Confidence interval
Model	B	Std. Error	Beta	t	p	Lower	Upper
1 (Constant)	−0.49	0.44		−1.11	0.301	−1.54	0.55
PET/CT SUV_LBM-maximum	0.97	0.20	0.87	4.73	0.002	0.48	1.46

Dependent variable: PET/MRI SUV_LBM-maximum.

Table 2.

Comparison of PET/CT SUV_LBM-maximum and PET/MRI SUV_LBM-maximum using a contrast media.

	PET/CT SUV_LBM-maximum (2.08±0.33)			PET/MRI SUV_LBM-maximum (1.47±0.27)
p				0.001
R				0.748
N		16			16
Model	Unstandardized coefficients		Standardized coefficients	t	p	95% Confidence interval
Model	B	Std. Error	Beta	t	p	Lower	Upper
1 (Constant)	0.19	0.33		0.58	0.572	−0.52	0.91
PET/CT SUV_LBM-maximum	0.61	0.15	0.74	3.90	0.002	0.27	0.95

Dependent variable: PET/MRI SUV_LBM-maximum

Table 3.

According to non-contrast media or contrast media used, SUV_LBM-maximum normal volumes corresponding of PET/CT and PET/MRI.

	Paired differences				R	p	Red (%)	Paired differences				R	p	Red (%)
	Mean	Std. Error	N	t	R	p	Red (%)	Mean	Std. Error	N	t	R	p	Red (%)
PET/CT Liver	2.0±0.3	0.10	10	10.7	0.860	0.0001	30.6	1.9±0.2	0.06	16	9.7	0.622	0.0001	32.6
PET/MRI Liver	1.4±0.1	0.06	10					1.3±0.2	0.07	16
PET/CT Spleen	1.5±0.1	0.05	10	6.8	0.250	0.0001	32.1	1.5±0.2	0.07	16	11.5	0.761	0.0001	35.8
PET/MRI Spleen	1.1±0.1	0.04	10					1.0±0.2	0.06	16
PET/CT Aorta	1.3±0.1	0.05	10	4.6	0.548	0.002	18.2	1.4±0.2	0.05	16	3.7	−0.053	0.002	22.8
PET/MRI Aorta	1.1±0.1	0.06	10					1.0±0.2	0.06	16
PET/CT Lumbar-1	1.9±0.4	0.15	10	3.2	0.658	0.012	21.1	1.6±0.4	0.11	16	7.0	0.907	0.0001	23.6
PET/MRI Lumbar-1	1.5±0.4	0.14	10					1.2±0.5	0.13	16
PET/CT Lumbar-2	1.9±0.4	0.14	10	3.6	0.702	0.006	24.7	1.9±1.2	0.33	16	3.1	0.897	0.007	27.3
PET/MRI Lumbar-2	1.4±0.5	0.17	10					1.3±0.8	0.22	16
PET/CT Lumbar-3	1.8±0.4	0.14	10	6.0	0.828	0.0001	27.6	1.6±0.3	0.07	16	6.6	0.569	0.0001	30.6
PET/MRI Lumbar-3	1.3±0.4	0.14	10					1.1±0.3	0.08	16
PET/CT Lumbar-5	0.7±0.0	0.02	10	4.5	−0.371	0.002	30.5	0.6±0.1	0.02	16	6.8	0.497	0.0001	30.7
PET/MRI Lumbar-5	0.5±0.1	0.03	10					0.4±0.1	0.02	16
PET/CT Cerebellum	5.7±1.0	0.33	10	10.7	0.914	0.0001	25.8	5.9±1.2	0.32	16	11.7	0.892	0.0001	31.3
PET/MRI Cerebellum	4.2±0.9	0.31	10					4.0±0.8	0.22	16
Total							26.3							29.3

TOOLS

Similar articles