Journal List > J Nutr Health > v.50(5) > 1081520

J Nutr Health. 2017 Oct;50(5):437-446. Korean.
Published online October 31, 2017.
© 2017 The Korean Nutrition Society
Effect of cassia cinnamon intake on improvement of the glycemic response: An updated meta-analysis: Focus on preparation of dehydrated powder and water extract
Jin Sook Kwak,1,2 Min young Park,1 and Oran Kwon1
1Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Korea.
2Biofood CRO Co., Ltd., Seoul 03721, Korea.

To whom correspondence should be addressed. tel: +82-2-3277-6860, Email:
Received August 18, 2017; Revised August 29, 2017; Accepted September 27, 2017.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



This meta-analysis aimed to evaluate the effect of cassia cinnamon (Cinnamomum. cassia and C. aromaticum) on the glycemic response with a focus on the preparation of dehydrated powder and water extract.


We searched Pubmed, Cochrane, EMBASE, Science Direct, and the Korean Studies Information Service System (KISS) through May 2017. In the meta-analysis for the preparation of powder, eight trials reporting fasting blood glucose (FBG), four trials reporting HbA1c, and three trials reporting the postprandial glycemic response were included. For the water extract, six trials reporting FBG and four trials reporting HbA1c were eligible for this study. A random-effects model was used to calculate the pooled effect size.


Cassia cinnamon powder intake significantly lowered FBG by −1.55 mmol/L (95% CI, −2.45, −0.64; p = 0.001) and the AUC of postprandial blood glucose level by −51.8 mmol/L·min (95% CI, −85.5, −18.1; p = 0.003). There was a significant difference in FBG between water extract of cinnamon and placebo of −0.76 mmol/L (95% CI, −1.09, −0.43; p = 0.000). However, blood HbA1c level was not significantly altered by any preparation of cinnamon. No statistical heterogeneity was observed for any analysis except in the case of FBG for cinnamon powder. Results of funnel plots and Egger's regression suggest a low likelihood of publication bias in all biomarkers (p > 0.05).


According to this meta-analysis, there was possible evidence to support a relationship between cassia cinnamon intake and fasting glucose in both preparation of powder and water extract. Furthermore, new evidence of the health benefits on postprandial glucose regulation of cinnamon powder was obtained.

Keywords: Meta-analysis; cinnamon; Cinnamomum cassia; Cinnamomum aromaticum; glycemic response


Fig. 1
Flow diagram of included and excluded studies
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Fig. 2
Forest plot results of the effect of cassia cinnamon powder supplementation on (A) fasting blood glucose, (B) HbA1c, (C) AUC of postprandial blood glucose
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Fig. 3
Forest plot results of the effect of cassia cinnamon water extract supplementation on (A) fasting blood glucose, (B) HbA1c
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Fig. 4
Funnel plot showing the effect of cassia cinnamon powder supplementation on (A) fasting blood glucose, (B) HbA1c, (C) AUC of postprandial blood glucose
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Fig. 5
Funnel plot showing the effect of cassia cinnamon water extract supplementation on (A) fasting blood glucose, (B) HbA1c
Click for larger image


Table 1
Details of trials included in this meta-analysis
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This work was supported by the Rural Development Administration in 2017(PJ011695).

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