Journal List > J Nutr Health > v.50(5) > 1081519

Kim, Lee, Nam, Kyung, Seo, and Chang: Comparing the effects of intake of sugar containing different levels of D-ribose in sugar on glycemic index and blood glucose response in healthy adults

Abstract

Purpose

To compare the extent to which three different levels of D-ribose in sugar reduce the glycemic index (GI) and blood glucose response in healthy adults.

Methods

Healthy adults (eight male and six female participants, n = 14) fasted for 14~16 h after eating the same dinner. Participants were then randomized to receive glucose, sucrose, sucrose containing 5% D-ribose (RB5), sucrose containing 10% D-ribose (RB10), or sucrose containing 14% D-ribose (RB14) every week on the same day for 10 weeks (repeating the sample twice). Blood samples were collected by finger prick before and 15, 30, 45, 60, 90, and 120 min after starting to eat.

Results

We observed a decreased glycemic response to sucrose containing D-ribose. GIs for sucrose, RB5, RB10, and RB14 were 67.39, 67.07, 47.57, and 45.62, respectively. GI values for sucrose and RB5 were similar to those for foods with a medium GI, and GI values for RB10 and RB14 were similar to those for foods with a low GI. The postprandial maximum blood glucose rise (Cmax) with RB14 was the lowest among the test foods. Cmax values for RB10 and RB14 were significantly lower than that for sucrose.

Conclusion

The results of this study suggest that sucrose containing D-ribose has an acute suppressive effect on GI and Cmax. In addition, D-ribose active elements in sugar may be effective in preventing blood glucose spikes induced by sucrose intake.

Figures and Tables

Fig. 1

Blood glucose responses after administration of the control food (glucose) and test food (sucrose, RB5, RB10 and RB14)

RB5: sucrose with 5% D-ribose powder, RB10: sucrose with 10% D-ribose powder, RB14: sucrose with 14% D-ribose powder.
a b c d: Values not sharing the same superscript letter are significantly different by repeated measures ANOVA test followed by Duncan's test.
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Table 1

The Control food and test food composition (%)

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1) RB5: sucrose with 5% D-ribose powder 2) RB10: sucrose with 10% D-ribose powder 3) RB14: sucrose with 14% D-ribose powder

Table 2

Provided meals and Nutrition Facts Table

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1) Rice, black rice, cooked/Bulgogi, beef bulgogi, cooked/Breaded laver roll, fried/Fish cake, fried/Laver, gimgui (salted roasted laver)/Kimchi, kimchi bokkeum, cooked/Imitation crab, gemassal/Rolled omelet, gyeran-mari/Sea weed salad, tosnamul (seasoned sea weed salad)/Jangajji, mujangajji (salting small radish roots)/Stir-fried, myeolchibokkeum (stir-fried dried small fish)/Pickled squid, ojingeo-jeosgal (salt-fermented and seasoned squid) 2) One of the two is provided for one meal. 3) Using data analytics Can 5.0 4) Carbohydrate, protein, total fat ratio

Table 3

Baseline characteristics of the subjects

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1) Mean ± SD 2) BMI: body mass index 3) AST: aspartate aminotransferase 4) ALT: alanine aminotransferase

Table 4

Incremental area under the curve (IAUC) values in subjects after ingestion of the control food and test food (n = 14)

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1) Incremental area under the curve 2) CV: coefficient of variation 3) Mean ± SD 4) RB5: sucrose with 5% D-ribose powder 5) RB10: sucrose with 10% D-ribose powder 6) RB14: sucrose with 14% D-ribose powder

a b c: Values not sharing the same superscript letter are significantly different by repeated measures ANOVA test followed by Duncan's test.

Table 5

Glycemic index (GI) of sucrose, RB5, RB10 and RB14 (n = 14)

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1) GI: glycemic index 2) CV: coefficient of variation 3) Mean ± SD 4) RB5: sucrose with 5% D-ribose powder 5) RB10: sucrose with 10% D-ribose powder 6) RB14 : sucrose with 14% D-ribose powder

a b: Values not sharing the same superscript letter are significantly different by repeated measures ANOVA test followed by Duncan's test.

Table 6

The changes in blood glucose variables of the control and test food (n = 14)

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1) Mean ± SD 2) NS: not significant at α = 0.05 3) RB5: sucrose with 5% D-ribose powder 4) RB10: sucrose with 10% D-ribose powder 5) RB14: sucrose with 14% D-ribose powder

a b c d: Values not sharing the same superscript letter are significantly different by repeated measures ANOVA test followed by Duncan's test.

Notes

This research was supported by a grant from TS Corporation in 2017.

References

1. World Health Organization. Sugars intake for adults and children. Geneva: World Health Organization;2015.
2. Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria. The DECODE study group. European Diabetes Epidemiology Group. Diabetes Epidemiology: Collaborative analysis Of Diagnostic criteria in Europe. Lancet. 1999; 354(9179):617–621.
3. Beisswenger P, Heine RJ, Leiter LA, Moses A, Tuomilehto J. Prandial glucose regulation in the glucose triad: emerging evidence and insights. Endocrine. 2004; 25(3):195–202.
crossref
4. Jenkins DJ, Wolever TM, Collier GR, Ocana A, Rao AV, Buckley G, Lam Y, Mayer A, Thompson LU. Metabolic effects of a low-glycemic-index diet. Am J Clin Nutr. 1987; 46(6):968–975.
crossref
5. Riccardi G, Rivellese AA, Giacco R. Role of glycemic index and glycemic load in the healthy state, in prediabetes, and in diabetes. Am J Clin Nutr. 2008; 87(1):269S–274S.
crossref
6. McKeown NM, Meigs JB, Liu S, Saltzman E, Wilson PW, Jacques PF. Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort. Diabetes Care. 2004; 27(2):538–546.
crossref
7. Ludwig DS, Majzoub JA, Al-Zahrani A, Dallal GE, Blanco I, Roberts SB. High glycemic index foods, overeating, and obesity. Pediatrics. 1999; 103(3):E26.
crossref
8. Korea Health Industry Development Institute. Sugar database compilation for commonly consumed foods. Cheongju: Ministry of Food and Drug Safety;2015.
9. Latulippe ME, Skoog SM. Fructose malabsorption and intolerance: effects of fructose with and without simultaneous glucose ingestion. Crit Rev Food Sci Nutr. 2011; 51(7):583–592.
crossref
10. DeChristopher LR, Uribarri J, Tucker KL. Intake of high fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent coronary heart disease, in U.S. adults, ages 45–59 y. BMC Nutr. 2017; 3(1):51.
crossref
11. Ibarra-Reynoso LDR, López-Lemus HL, Garay-Sevilla ME, Malacara JM. Effect of restriction of foods with high fructose corn syrup content on metabolic indices and fatty liver in obese children. Obes Facts. 2017; 10(4):332–340.
crossref
12. Kim JH. Spotlight functional sweeteners. Food Ind Nutr. 2010; 15(2):26–28.
13. Ministry of Food and Drug Safety (KR). Food additive standard [Internet]. Cheongju: Ministry of Food and Drug Safety;cited 2016 Nov 29. Available from: http://www.foodsafetykorea.go.kr/portal/safefoodlife/foodAditive/foodAdditiveRvlv.do?page_gubun=1&procs_cl=1&menu_no=306&menu_grp=MENU_GRP01.
14. Bierman EL, Baker EM, Plough IC, Hall WH. Metabolism of dribose in diabetes mellitus. Diabetes. 1959; 8(6):455–458.
crossref
15. Steinberg T, Poucher RL, Sarin RK, Rees RB, Gwinup G. Oral administration of D-ribose in diabetes mellitus. Diabetes. 1970; 19(1):11–16.
crossref
16. Han C, Lu Y, Wei Y, Liu Y, He R. D-ribose induces cellular protein glycation and impairs mouse spatial cognition. PLoS One. 2011; 6(9):e24623.
crossref
17. Hetenyi G Jr, Ishiwata K. Effect of D-(--)-ribose on the turnover of glucose in dogs. Am J Physiol. 1968; 214(6):1333–1339.
crossref
18. Ishiwata K, Hetenyi G Jr, Vranic M. Effect of D-glucose or D-ribose on the turnover of glucose in pancreatectomized dogs maintained on a matched intraportal infusion of insulin. Diabetes. 1969; 18(12):820–827.
crossref
19. Ismail ZB, Abu-Baker N, Alzoubi K, Al-Zhgoul M, Al-Essa MK, Khlouf S, Al-Saleh A, Al-Omari B, Abu-Tayeh R, Shomaf M, Battah A, Al-Hadidi K. Evaluation of alpha-D-ribofuranose (D-ribose) toxicity after intravenous administration to rabbits. Hum Exp Toxicol. 2012; 31(8):820–829.
20. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med. 2006; 12(9):857–862.
crossref
21. Seifert JG, Subudhi AW, Fu MX, Riska KL, John JC, Shecterle LM, St Cyr JA. The role of ribose on oxidative stress during hypoxic exercise: a pilot study. J Med Food. 2009; 12(3):690–693.
crossref
22. Lee YH, Shin KO, Kim KS, Kim YI, Woo JH. The effects of D-ribose supplementation on the production of blood fatigue factors after maximal intensity exercise. J Life Sci. 2011; 21(5):729–733.
crossref
23. Foster-Powell K, Holt SH, Brand-Miller JC. International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr. 2002; 76(1):5–56.
crossref
24. Brouns F, Bjorck I, Frayn KN, Gibbs AL, Lang V, Slama G, Wolever TM. Glycaemic index methodology. Nutr Res Rev. 2005; 18(1):145–171.
crossref
25. Wolever TM, Vorster HH, Björck I, Brand-Miller J, Brighenti F, Mann JI, Ramdath DD, Granfeldt Y, Holt S, Perry TL, Venter C, Xiaomei Wu. Determination of the glycaemic index of foods: interlaboratory study. Eur J Clin Nutr. 2003; 57(3):475–482.
crossref
26. Nam H, Kyung M, Seo S, Jung S, Chang MJ. Effect of different levels of xylooligosaccharide in sugar on glycemic index and blood glucose response in healthy adults. J Nutr Health. 2015; 48(5):398–406.
crossref
27. Moon SH, Lee KS, Kyung MO, Jung SW, Park YJ, Yang CK. Study on the proper D-xylose concentration in sugar mixture to reduce glycemic index (GI) value in the human clinical model. Korean J Food Nutr. 2012; 25(4):787–792.
crossref
28. Lee JS, Kim AR, Nam H, Kyung M, Seo S, Chang MJ. Effect of varying levels of xylobiose in sugar on glycemic index and blood glucose response in healthy adults. J Nutr Health. 2016; 49(5):295–303.
crossref
29. Brand-Miller JC, Holt SH, Pawlak DB, McMillan J. Glycemic index and obesity. Am J Clin Nutr. 2002; 76(1):281S–285S.
crossref
30. Hodge AM, English DR, O'Dea K, Giles GG. Glycemic index and dietary fiber and the risk of type 2 diabetes. Diabetes Care. 2004; 27(11):2701–2706.
crossref
31. Ludwig DS. Dietary glycemic index and obesity. J Nutr. 2000; 130:2S Suppl. 280S–283S.
crossref
32. Pliml W, von Arnim T, Stäblein A, Hofmann H, Zimmer HG, Erdmann E. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. Lancet. 1992; 340(8818):507–510.
crossref
33. Gross M, Zöllner N. Serum levels of glucose, insulin, and C-peptide during long-term D-ribose administration in man. Klin Wochenschr. 1991; 69(1):31–36.
crossref
34. Tao SU, Rong-Qiao HE. An insight of D-ribose metabolic imbalance in Type 2 diabetes mellitus. Prog Biochem Biophys. 2015; 42(4):390–392.
35. Bae YJ, Bak YK, Kim B, Kim MS, Lee JH, Sung MK. Coconut-derived D-xylose affects postprandial glucose and insulin responses in healthy individuals. Nutr Res Pract. 2011; 5(6):533–539.
crossref
36. Shibanuma K, Degawa Y, Houda K. Determination of the transient period of the EIS complex and investigation of the suppression of blood glucose levels by L-arabinose in healthy adults. Eur J Nutr. 2011; 50(6):447–453.
crossref
37. Seri K, Sanai K, Matsuo N, Kawakubo K, Xue C, Inoue S. L-arabinose selectively inhibits intestinal sucrase in an uncompetitive manner and suppresses glycemic response after sucrose ingestion in animals. Metabolism. 1996; 45(11):1368–1374.
crossref
38. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest. 1958; 37(5):719–735.
crossref
39. Sahlin K, Broberg S, Ren JM. Formation of inosine monophosphate (IMP) in human skeletal muscle during incremental dynamic exercise. Acta Physiol Scand. 1989; 136(2):193–198.
crossref
40. Naitö Y. Biochemical studies on d-ribose, with special reference to the mechanism of absorption of sugars from intestinal tract. J Biochem. 1944; 36(1):131–161.
41. Griffiths JC, Borzelleca JF, St Cyr J. Sub-chronic (13-week) oral toxicity study with D-ribose in Wistar rats. Food Chem Toxicol. 2007; 45(1):144–152.
crossref
42. Eijnde BO, Van Leemputte M, Brouns F, Van Der Vusse GJ, Labarque V, Ramaekers M, Van Schuylenberg R, Verbessem P, Wijnen H, Hespel P. No effects of oral ribose supplementation on repeated maximal exercise and de novo ATP resynthesis. J Appl Physiol (1985). 2001; 91(5):2275–2281.
43. Yoon JW, Lee SE, Park H. Effect of D-ribose supplementation on run-to-exhaustion time and antioxidative capacity under sea level or high altitude condition. J Exerc Nutr Biochem. 2009; 13(1):45–50.
44. Shecterle LM, St Cyr JA. Dermal benefits of topical D-ribose. Clin Cosmet Investig Dermatol. 2009; 2:151–152.
45. Cleveland Clinic Wellness (US). Ribose supplement review [Internet]. Cleveland (OH): Cleveland Clinic Wellness;cited 2017 Aug 10. Available from: http://www.clevelandclinicwellness.com/Features/Pages/Ribose.aspx.
46. Su T, He R. D-ribose, an overlooked player in type 2 diabetes mellitus? Sci China Life Sci. 2014; 57(3):361.
crossref
47. Seifert J, Frelich A, Shecterle L, St Cyr J. Assessment of hematological and biochemical parameters with extended D-ribose ingestion. J Int Soc Sports Nutr. 2008; 5(1):13.
crossref
48. Ministry of Food and Drug Safety (KO). The first comprehensive plan for the sugar reduction ('16-'20). Cheongju: Ministry of Food and Drug Safety;2016.
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