Journal List > J Nutr Health > v.50(3) > 1081499

J Nutr Health. 2017 Jun;50(3):246-256. Korean.
Published online June 30, 2017.  https://doi.org/10.4163/jnh.2017.50.3.246
© 2017 The Korean Nutrition Society
Association of total dietary antioxidant capacity with oxidative stress and metabolic markers among patients with metabolic syndrome
Dongwoo Ham,1 Shinyoung Jun,1 Minji Kang,2 Sangah Shin,3 Gyung-Ah Wie,4 Hyun Wook Baik,5 and Hyojee Joung1,6
1Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea.
2Center for Gendered Innovations in Science and Technology Researches (GISTER), Korea Federation of Women's Science & Technology Associations, Seoul 06130, Korea.
3Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul 03080, Korea.
4Department of Clinical Nutrition, Research Institute & Hospital, National Cancer Center, Goyang-si 10408, Korea.
5Department of Internal Medicine, Division of Gastroenterology & Clinical Nutrition, DMC Bundang Jesaeng Hospital, Seongnam-si 13590, Korea.
6Institute of Health and Environment, Seoul National University, Seoul 08826, Korea.

To whom correspondence should be addressed. tel: +82-2-880-2831, Email: hjjoung@snu.ac.kr
Received May 04, 2017; Revised May 12, 2017; Accepted May 29, 2017.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Purpose

This study aimed to investigate the association of total dietary antioxidant capacity (TAC) with oxidative stress and metabolic markers among patients with metabolic syndrome according to gender.

Methods

A total of 346 subjects aged 30~59 years with two or more risk factors of metabolic syndrome were recruited from a general hospital near Seoul in South Korea between 2010 and 2012 based on data from the medical checkup. Biochemical indices for oxidative stress and metabolic markers were measured. Food consumption data from 3-day food records were linked with the antioxidant capacity database for commonly consumed Korean foods to estimate individual's TAC.

Results

Average dietary TAC of the study subjects was 132.0 mg VCE/d/1,000 kcal in men and 196.4 mg VCE/d/1,000 kcal in women. Levels of γ-glutamyltransferase (GGT), systolic blood pressure, diastolic blood pressure, and blood triglycerides were reduced significantly according to increasing TAC in men, but there was no significant trend in women. Intakes of total flavonoids and carotenoids were significantly negatively correlated with GGT (p < 0.05) and d-ROMs (p < 0.01) in men, whereas those of α-tocopherol (p < 0.05) and γ-tocopherol (p < 0.05) were positively correlated with biological antioxidant potential (BAP) in women. The odds ratio of high oxidative stress indices and abnormal metabolic markers according to TAC level were not significant in either men or women.

Conclusion

The results show that dietary TAC was partially associated with oxidative stress and metabolic markers among patients with metabolic syndrome. Further research is required for elucidating the association between dietary TAC and incidence of metabolic syndrome and chronic diseases within a large population in prospective studies.

Keywords: metabolic syndrome; antioxidant; oxidative stress; metabolic marker; total antioxidant capacity

Tables


Table 1
General characteristics of the study subjects
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Table 2
Oxidative stress and metabolic markers by tertiles of total dietary antioxidant capacity density among the study subjects
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Table 3
Spearman correlation coefficient between antioxidant intake density and oxidative stress indices of the study subjects
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Table 4
Odds ratio of high oxidative stress indices and abnormal metabolic markers by tertiles of total dietary antioxidant capacity density among the study subjects
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Notes

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2014R1A2A2A01003138).

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