Journal List > J Nutr Health > v.49(5) > 1081453

J Nutr Health. 2016 Oct;49(5):295-303. Korean.
Published online October 31, 2016.
© 2016 The Korean Nutrition Society
Effect of varying levels of xylobiose in sugar on glycemic index and blood glucose response in healthy adults
Jung-Sug Lee,1,** A-Reum Kim,1,** Hyekyoung Nam,1 Myungok Kyung,2 Sheungwoo Seo,2 and Moon-Jeong Chang1
1Department of Food & Nutrition, Kookmin University, Seoul 02707, Korea.
2R&D Center, TS Corporation, Incheon 22300, Korea.

To whom correspondence should be addressed. tel: +82-2-910-4776, Email:

**These authors contributed equally to this work.

Received September 19, 2016; Revised October 04, 2016; Accepted October 07, 2016.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



The objective of this study was to compare the effects of three different levels of xylobiose containing sucrose on glycemic indices based on oral glucose tolerance test (OGTT) and blood glucose response in healthy adults.


Healthy adults (six male and five female participants, n = 11) underwent 14~16 hr of fasting. Subsequently, all participants took 50 g of available carbohydrates from glucose, sucrose containing 7% xylobiose (XB 7), sucrose containing 10% xylobiose (XB 10), or sucrose containing 14% xylobiose (XB 14) every week on the same day for 8 weeks. Finger prick blood was taken before and 15, 30, 45, 60, 90, and 120 min after starting to eat.


We observed reduction of the glycemic response to sucrose containing xylobiose. The glycemic indices of XB 7, XB 10, and XB 14 were 57.0, 53.6, and 49.7, respectively. The GI values of XB 7 were similar to those of foods with medium GI, and the GI values of XB 10 and XB 14 were similar to those of foods with low GI. The postprandial maximum blood glucose rise (Cmax) of XB 14 was the lowest among the test foods. XB 7, XB 10, and XB 14 showed significantly lower areas under the glucose curve (AUC) for 0~30 min, 0~60 min, 0~90 min and 0~120 min compared to glucose.


The results of this study suggest that sucrose containing xylobiose has an acute suppressive effect on GI and postprandial maximum blood glucose rise. In addition, levels of xylobiose in sugar may allow more precise assessment of carbohydrate tolerance despite lower glycemic responses in a dose-dependent manner.

Keywords: xylobiose (XB); glycemic index (GI); blood glucose; healthy adults


Table 1
Test food composition in the clinical trial
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Table 2
Baseline characteristics of the subjects in the clinical trial (n = 11)
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Table 3
Glycemic indices of XB 7, XB 10 and XB 14 (n = 11)
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Table 4
The changes in blood glucose variables of the test food (n = 11)
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Table 5
Area under the curve (AUC) values in subjects after ingestion of Glucose, XB 7, XB 10 and XB 14 in each group of the test food (Unit : mg/dL/h)
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This research was supported by High Value-added Food Technology Development Program (Project number: 313024-03-3-HD020), Ministry for Food, Agriculture, Forestry, Republic of Korea.

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