Journal List > J Nutr Health > v.48(3) > 1081389

J Nutr Health. 2015 Jun;48(3):221-227. Korean.
Published online June 30, 2015.
© 2015 The Korean Nutrition Society
Association between compliance with dietary guidelines and Alzheimer's disease in Korean elderly
Ji Eun Kim,1 Sangah Shin,2,3 Dong Woo Lee,4 Joon Hyun Park,4 Eun Joo Hong,5 and Hyojee Joung1,2
1Department of Public Health Nutrition of Graduate School of Public Health, Seoul National University, Seoul 151-742, Korea.
2Institute of Health and Environment. Seoul National University, Seoul 151-742, Korea.
3Department of Global Health Policy and AXA Department of Health and Human Security, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
4Department of Psychiatry, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul 139-707, Korea.
5Department of Economics and Finance, Hanyang Cyber University, Seoul 133-791, Korea.

To whom correspondence should be addressed. tel: +82-2-880-2716, Email:
Received January 28, 2015; Revised February 16, 2015; Accepted June 03, 2015.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



Confronting the growing burden of dementia requires understanding the causes and predictors of dementia in order to develop preventive strategies. In Korea a large proportion (71%) of dementia is Alzheimer's disease, and the risk factors have not yet been elucidated. Dietary factors may be possible risk factors, however research on the relationship between Alzheimer's disease and dietary behaviors has been insufficient. The purpose of this study was to investigate the association between compliance with the "Dietary Guidelines for Elderly (The Ministry of Health and Welfare, 2011)" and Alzheimer's disease among Korean elderly.


Elderly persons who visited a University hospital or a dementia center of Seoul and agreed to participate in the examinations were selected. Among 277 subjects, 89 Alzheimer patients were selected with diagnosis and 118 subjects were assigned to the control group. Diagnosis of Alzheimer's disease was based on Alzheimer's disease criteria of Diagnostic and Statistical manual of Mental Disorders, 4th edition (DSM-IV) and criteria of National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and related Disorders Association (NINCDS-ADRDA). Information on the general characteristics, health related behaviors and compliance with the dietary guidelines for Korean elderly was collected by face to face interview using a structured questionnaire. Anthropometric variables were measured during the survey.


Total compliance score of dietary guidelines was significantly lower in the Alzheimer's disease group than in the control group (p = 0.0001). The odds ratio of Alzheimer's disease was significantly decreased in the group with the highest dietary guideline compliance score (OR = 0.47, 95 % CI = 0.18~1.09) compared to the group with the lowest compliance score.


The results indicate that increasing compliance with the dietary guidelines could be an effective strategy to decrease the risk of Alzheimer's disease among Korean elderly.

Keywords: compliance; dietary guidelines; Alzheimer's disease


Table 1
General characteristics of subjects
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Table 2
Dietary behaviors of subjects
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Table 3
Adherence to the dietary guidelines for Korean elderly of subjects
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Table 4
Multivariate adjusted odds and 95% confidence intervals for Alzheimer's disease by the level of adherence to the dietary guidelines
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This research was supported by the grant from the Brain Korea 21 project in 2012 and the Korea Food and Drug Administration (11162유해물701).

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