Effects of short-term supplementation of erythritol-salt on urinary electrolyte excretion in rats

Myungok Kyung; Ji Ye Lim; Kyungsun Lee; Sangwon Jung; Keunbum Choe; Chang-kun Yang; Yuri Kim

doi:10.4163/jnh.2014.47.2.99

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Kyung, Lim, Lee, Jung, Choe, Yang, and Kim: Effects of short-term supplementation of erythritol-salt on urinary electrolyte excretion in rats

Research Article

Journal of Nutrition and Health 2014; 47(2): 99-105.

Published online: 30 April 2014

DOI: https://doi.org/10.4163/jnh.2014.47.2.99

Effects of short-term supplementation of erythritol-salt on urinary electrolyte excretion in rats

Myungok Kyung^1,^**, Ji Ye Lim^2,^**, Kyungsun Lee¹, Sangwon Jung¹, Keunbum Choe¹, Chang-kun Yang³, Yuri Kim²

¹R&D Center, TS Corporation, 116 Wolmi-ro, Jung-gu, Incheon 400-201, Korea.

²Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea.

³TS Food & System, Nonhyeon-ro 422-gil, Gangnam-gu, Seoul 135-921, Korea.

To whom correspondence should be addressed. tel: +82-2-3277-4485, yuri.kim@ewha.ac.kr

Equal contributor:

**Equal contribution as the first author

Received 24 February 2014 Revised 19 March 2014 Accepted 10 April 2014

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

This study was conducted in order to investigate the diuretic effects of Erythritol (ET) salt on urinary electrolyte excretion in Sprague-Dawley Rats.

Methods

Animals were divided into two groups: Salt group (n = 7) and Salt + ET fed group (n = 7). Animals were provided food and water ad libitum. Supplements were administered orally to animals for one week.

Results

Body weights were not statistically different between groups either on Day 1 or Day 7. However, water consumption of the Salt + ET group was significantly higher than that of the Salt group on Day 1 and Day 7. Urine volume of the Salt + ET group was approximately 27% and 38% higher than that of the Salt group on Day 1 and Day 7. In addition, we found that the total amounts of urinary electrolytes, such as sodium and potassium, of the Salt + ET group were significantly higher than those of the Salt group on Day 7. We also found that serum electrolyte concentrations did not differ between two groups. These results demonstrated that salt intake with ET was effective in increasing urinary electrolyte excretion, which might be caused by higher water intake and diuretic effect inhibiting reabsorption of water, sodium, and potassium in renal tubules.

Conclusion

The results suggest that short-term supplementation of ET salt can be a potential diuretic agent by inhibiting sodium and potassium reabsorption and inducing loss of water.

Keywords: erythritol, salt, electrolyte excretion, diuretic effect, hypertension

Figures and Tables

Fig. 1

Effects of the Erythritol-Salt on serum concentration of sodium and potassium. A: The serum concentrtion of sodium in two groups was measured at Day 7. B: The serum concentration of potassium in two groups was measured at Day 7. Values are expressed as mean ± SD (n = 7). ^*: significantly different from Salt group value (p < 0.05).

Table 1

Composition of salt and erythritol (ET) in the diet

1) b.w: body weight

Table 2

Weight, daily food intake, and daily water intake at Day 1 and Day 7 in two groups¹⁾

1) Values are expressed as Mean ± SD (n = 7). 2) significantly different from Day 1 value (p < 0.05) 3) significantly different from Salt group value (p < 0.05)

Table 3

Urine volume and urinary minerals between Day 1 and Day 7 of two groups¹⁾

1) Values are expressed as Mean ± SD (n = 7). 2) significantly different from Day 1 value (p < 0.05) 3) significantly different from Salt group value (p < 0.05)

Notes

This research was supported by High Value-added Food Technology Development Program (Project number: 313024-03-1-CG000), Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea.

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