Journal List > J Nutr Health > v.47(2) > 1081374

J Nutr Health. 2014 Apr;47(2):99-105. Korean.
Published online April 30, 2014.
© 2014 The Korean Nutrition Society
Effects of short-term supplementation of erythritol-salt on urinary electrolyte excretion in rats
Myungok Kyung,1,** Ji Ye Lim,2,** Kyungsun Lee,1 Sangwon Jung,1 Keunbum Choe,1 Chang-kun Yang,3 and Yuri Kim2
1R&D Center, TS Corporation, 116 Wolmi-ro, Jung-gu, Incheon 400-201, Korea.
2Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea.
3TS Food & System, Nonhyeon-ro 422-gil, Gangnam-gu, Seoul 135-921, Korea.

To whom correspondence should be addressed. tel: +82-2-3277-4485, Email:

**Equal contribution as the first author

Received February 24, 2014; Revised March 19, 2014; Accepted April 10, 2014.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



This study was conducted in order to investigate the diuretic effects of Erythritol (ET) salt on urinary electrolyte excretion in Sprague-Dawley Rats.


Animals were divided into two groups: Salt group (n = 7) and Salt + ET fed group (n = 7). Animals were provided food and water ad libitum. Supplements were administered orally to animals for one week.


Body weights were not statistically different between groups either on Day 1 or Day 7. However, water consumption of the Salt + ET group was significantly higher than that of the Salt group on Day 1 and Day 7. Urine volume of the Salt + ET group was approximately 27% and 38% higher than that of the Salt group on Day 1 and Day 7. In addition, we found that the total amounts of urinary electrolytes, such as sodium and potassium, of the Salt + ET group were significantly higher than those of the Salt group on Day 7. We also found that serum electrolyte concentrations did not differ between two groups. These results demonstrated that salt intake with ET was effective in increasing urinary electrolyte excretion, which might be caused by higher water intake and diuretic effect inhibiting reabsorption of water, sodium, and potassium in renal tubules.


The results suggest that short-term supplementation of ET salt can be a potential diuretic agent by inhibiting sodium and potassium reabsorption and inducing loss of water.

Keywords: erythritol; salt; electrolyte excretion; diuretic effect; hypertension


Fig. 1
Effects of the Erythritol-Salt on serum concentration of sodium and potassium. A: The serum concentrtion of sodium in two groups was measured at Day 7. B: The serum concentration of potassium in two groups was measured at Day 7. Values are expressed as mean ± SD (n = 7). *: significantly different from Salt group value (p < 0.05).
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Table 1
Composition of salt and erythritol (ET) in the diet
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Table 2
Weight, daily food intake, and daily water intake at Day 1 and Day 7 in two groups1)
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Table 3
Urine volume and urinary minerals between Day 1 and Day 7 of two groups1)
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This research was supported by High Value-added Food Technology Development Program (Project number: 313024-03-1-CG000), Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea.

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