Relationship between serum 25-hydroxyvitamin D and chronic obstructive pulmonary disease in males in the fifth Korean national health and nutrition examination survey

In Kyung Jung

doi:10.4163/jnh.2014.47.5.321

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Jung: Relationship between serum 25-hydroxyvitamin D and chronic obstructive pulmonary disease in males in the fifth Korean national health and nutrition examination survey

Research Article

Journal of Nutrition and Health 2014; 47(5): 321-329.

Published online: 31 October 2014

DOI: https://doi.org/10.4163/jnh.2014.47.5.321

Relationship between serum 25-hydroxyvitamin D and chronic obstructive pulmonary disease in males in the fifth Korean national health and nutrition examination survey

In Kyung Jung

Department of Beauty Art, Honam University, Gwangju 502-791, Korea.

To whom correspondence should be addressed. (jungik@honam.ac.kr)

Received 28 August 2014 Revised 22 September 2014 Accepted 14 October 2014

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

The aim of this study was to determine the relationship between serum concentrations of 25-hydroxyvitamin D [25(OH)D] and chronic obstructive pulmonary disease (COPD) prevalence.

Methods

The analysis was performed using data from the Fifth Korean National Health and Nutrition Examination Survey, a cross-sectional survey of the Korean civilian population conducted from 2010 to 2012. The analyses were restricted to males who were 40 years of age and above. Complex sample multiple logistic regression analyses were used to examine the associations of COPD prevalence with 25(OH)D and other factors.

Results

FEV₁/FEV₆ varied significantly with smoking status, age, household income, education level, occupation, body mass index (BMI), and physical activity (p < 0.05). In univariate analysis, smoking status, BMI, household income, education level, and occupation showed association with COPD (p < 0.05), but vitamin D was not associated with COPD (p = 0.078). However, when adjusted with smoking status, household income, education level, occupation, BMI, age, and smoking index, the lowest quartile of 25(OH)D showed OR 1.643 (95% CI 1.161-2.236) compared to 3rd quartile (p = 0.024).

Conclusion

A significant relationship was observed between serum concentration of 25(OH)D and COPD.

Keywords: vitamin D, 25(OH)D, COPD, FEV₁/FEV₆, logistic regression analysis

Figures and Tables

Table 1

Serum 25-hydroxyvitamin D levels of males according to smoking status and the other factors in KNHANES V¹⁾

Abbreviations: SE, standard error. N, unweighted frequency. FEV₁, forced expiratory volume for 1 second. FEV₆, forced expiratory volume for 6 seconds. BMI, body mass index

1) Data are expressed as estimates ± SE in ng/ml of 25-hydroxyvitamin D. 2) Calculated by complex sample general linear model (CSGLM)

Table 2

Differences in FEV₁ and FEV₁/FEV₆ by each variables for males in KNHANES V

Abbreviations: FEV₁, forced expiratory volume for 1 second. FEV₆, forced expiratory volume for 6 seconds. 25(OH)D, 25-hydroxyvitamin D. N, unweighted frequency. SE, standard error.

1) Calculated by complex sample general linear model (CSGLM).

Table 3

Unadjusted and adjusted odds ratios of chronic obstructive pulmonary disease by vitamin D, demographic factors and smoking factors for males aged 40 or above in KNHANES V¹⁾

Abbreviations: OR, odds ratio. CI, confidence interval. BMI, body mass index. SI, smoking index

1) Data are given as OR (95% confidence interval), unless otherwise indicated. 2) Calculated by complex sample logistic regression analysis

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