Journal List > J Nutr Health > v.47(5) > 1081351

J Nutr Health. 2014 Oct;47(5):321-329. Korean.
Published online October 31, 2014.
© 2014 The Korean Nutrition Society
Relationship between serum 25-hydroxyvitamin D and chronic obstructive pulmonary disease in males in the fifth Korean national health and nutrition examination survey
In Kyung Jung
Department of Beauty Art, Honam University, Gwangju 502-791, Korea.

To whom correspondence should be addressed. (Email: )
Received August 28, 2014; Revised September 22, 2014; Accepted October 14, 2014.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



The aim of this study was to determine the relationship between serum concentrations of 25-hydroxyvitamin D [25(OH)D] and chronic obstructive pulmonary disease (COPD) prevalence.


The analysis was performed using data from the Fifth Korean National Health and Nutrition Examination Survey, a cross-sectional survey of the Korean civilian population conducted from 2010 to 2012. The analyses were restricted to males who were 40 years of age and above. Complex sample multiple logistic regression analyses were used to examine the associations of COPD prevalence with 25(OH)D and other factors.


FEV1/FEV6 varied significantly with smoking status, age, household income, education level, occupation, body mass index (BMI), and physical activity (p < 0.05). In univariate analysis, smoking status, BMI, household income, education level, and occupation showed association with COPD (p < 0.05), but vitamin D was not associated with COPD (p = 0.078). However, when adjusted with smoking status, household income, education level, occupation, BMI, age, and smoking index, the lowest quartile of 25(OH)D showed OR 1.643 (95% CI 1.161-2.236) compared to 3rd quartile (p = 0.024).


A significant relationship was observed between serum concentration of 25(OH)D and COPD.

Keywords: vitamin D; 25(OH)D; COPD; FEV1/FEV6; logistic regression analysis


Table 1
Serum 25-hydroxyvitamin D levels of males according to smoking status and the other factors in KNHANES V1)
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Table 2
Differences in FEV1 and FEV1/FEV6 by each variables for males in KNHANES V
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Table 3
Unadjusted and adjusted odds ratios of chronic obstructive pulmonary disease by vitamin D, demographic factors and smoking factors for males aged 40 or above in KNHANES V1)
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