Journal List > J Nutr Health > v.47(5) > 1081350

J Nutr Health. 2014 Oct;47(5):313-320. Korean.
Published online October 31, 2014.  https://doi.org/10.4163/jnh.2014.47.5.313
© 2014 The Korean Nutrition Society
Hypoglycemic and antioxidant effects of jaceosidin in streptozotocin-induced diabetic mice
Eunkyo Park,1 Byoung-Mog Kwon,2 In-Kyung Jung,3 and Jung-Hyun Kim3
1Department of Home Economics, Graduate School, Chung-Ang University, Seoul 156-756, Korea.
2Division of Biomedical Convergent, Korea Research Institute of Bioscience & Biotechnology, Daejeon 305-806, Korea.
3Department of Physical Education, Chung-Ang University, Seoul 156-756, Korea.

To whom correspondence should be addressed. tel: +82-02-820-5378, Email: jjhkim@cau.ac.kr
Received July 24, 2014; Revised August 08, 2014; Accepted August 27, 2014.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Purpose

In this study, we investigated the effects of jaceosidin on blood glucose regulation in type 1 diabetic mice.

Methods

C57BL/6 mice were divided into four groups; normal control (Normal), diabetes control (D-Control), diabetes low-jaceosidin (D-0.005%), and diabetes high-jaceosidin (D-0.02%). Type 1 diabetes was induced by streptozotocin and mice were then fed a diet containing jaceosidin for eight weeks. Fasting blood glucose, oral glucose tolerance test, insulin tolerance test, lipid peroxidation, and antioxidant enzyme activities were assessed.

Results

Jaceosidin supplementation for eight weeks had no effect on body weight, organ weight, and blood lipid profiles. However, jaceosidin supplementation significantly lowered fasting blood glucose level and reduced insulin resistance. We also found that jaceosidin supplementation increased antioxidant capacity by enhancement of catalase and GSH-px activities.

Conclusion

These results suggest that jaceosidin could be a therapeutic candidate to ameliorate hyperglycemia through increase of antioxidant enzyme activity.

Keywords: jaceosidin; diabetes mellitus; antioxidant; lipid peroxidation

Figures


Fig. 1
Effects of jaceosidin intake on fasting blood glucose, oral glucose tolerance test and insulin tolerance test in STZ-induced mice. A: Fasting blood glucose levels after 8 weeks of diet, B: Oral glucose tolerance test (OGTT) was performed at 6 week of diet. C: Area of under curve (AUC) was calculated based on OGTT results. D: Insulin tolerance test (ITT) was performed at 7 week of diet. E: AUC was calculated based on ITT results.
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Tables


Table 1
Composition of experimental diets (g/Kg diet)
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Table 2
Effects of jaceosidin on changes in body weight, food intake, and food efficiency ratio in STZ-induced diabetic mice
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Table 3
Effects of jaceosidin on organ weight in STZ-induced diabetic mice
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Table 4
Effects of jaceosidin on liver function in STZ-induced diabetic mice
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Table 5
Effects of jaceosidin on liver lipid peroxidation and antioxidant enzyme activities in STZ-induced diabetic mice
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Notes

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (NRF-2013R1A1A2006028).

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