Journal List > J Nutr Health > v.47(3) > 1081335

J Nutr Health. 2014 Jun;47(3):176-185. Korean.
Published online June 30, 2014.
© 2014 The Korean Nutrition Society
Relationship between flavonoids intake and metabolic syndrome in Korean women with polycystic ovary syndrome
Ji Soo Oh,1 Mi Jin Ahn,1 Chan Jung Han,1 Hyesook Kim,1 Oran Kwon,1 Hye Won Chung,2 and Namsoo Chang1
1Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea.
2Department of Obstetrics and Gynecology, Ewha Womans University College of Medicine, Seoul 158-710, Korea.

To whom correspondence should be addressed. tel: +82-2-3277-4426, Email:
Received March 17, 2014; Revised April 03, 2014; Accepted June 03, 2014.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



The purpose of this study was to investigate the relationship between dietary flavonoids intake and metabolic syndrome (MetS) in Korean women with polycystic ovary syndrome (PCOS).


A total of 223 subjects (mean age; 27.3 ± 4.2 yrs, range; 17-38 yrs) were divided into the MetS group (n = 27) and non-MetS group (n = 196). Dietary intake data were assessed by 24-hour recall method for two non-consecutive days and the average of the two days was used to estimate the usual dietary intake. Dietary habits were assessed using the Mini Dietary Assessment (MDA) score. We analyzed the intakes of six flavonoid classes (anthocyanidins, flavan-3-ols, flavanones, flavones, flavonols, and iso-flavones) using a flavonoids database.


After adjustment for age, total energy intake, alcohol consumption, smok-ing, regular exercise, and oral contraceptive use, dietary flavonols intake was significantly lower in the MetS group (5.1 ± 2.4 mg/d) than in the non-MetS group (8.9 ± 2.8 mg/d) (p = 0.0472). Intakes of other flavonoids except for flavonols did not differ between the two groups. In MDA scores, significant differences were observed only for that related to daily con-sumption of fruit or fruit juice (p = 0.0180). A significant inverse relationship was observed between flavonols intake and the risk of MetS (4th vs. 1st quartile, OR = 0.11, 95% CI = 0.02-0.62, p for trend = 0.0131).


These results sug-gest that higher intake of flavonols may be beneficial for MetS in PCOS women.

Keywords: PCOS; metabolic syndrome; dietary flavonoids intake


Table 1
General characteristics according to MetS in subjects1)
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Table 2
Blood profiles according to MetS in subjects1)
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Table 3
Dietary plant foods, nutrients and flavonoids intakes according to MetS in subjects1)
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Table 4
Mini dietary assessment (MDA) scores1) of the subjects according to MetS in subjects2)
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Table 5
Odds ratio (OR) and 95% confidence interval (CI) of MetS by quartiles of dietary flavonols intakes1)
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This research was supported by a fund (2010-E63010-00) by Research of Korea Centers for Disease Control and Prevention and by the Brain Korea 21 Plus.

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