Journal List > J Nutr Health > v.46(6) > 1081317

J Nutr Health. 2013 Dec;46(6):511-520. Korean.
Published online December 31, 2013.
© 2013 The Korean Nutrition Society
Association of MCP-1 polymorphism with cardiovascular disease risk factors in Korean elderly
Hee Jung Park
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea.

To whom correspondence should be addressed. (Email: )
Received October 04, 2013; Revised October 14, 2013; Accepted November 28, 2013.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Monocyte chemoattractant protein-1 (MCP-1) plays an important role in cardiovascular disease (CVD). Genetic polymorphism in the regulatory regions of MCP-1 could affect MCP-1 expression. The purpose of the study was to explore the possible association of MCP-1 -2518 A/G genetic polymorphism and CVD risk factors in the elderly Korean population. Dietary, anthropometric, and biochemical factors were assessed in 168 subjects. The frequency of A/A, G/A, and G/G genotypes was 14.2%, 45.8%, and 40.0%, respectively. The blood level of MCP-1 was significantly higher in subjects with A/A genotype. The MCP-1 level was significantly higher in A/A genotype with hypercholesterolemia than in other genotypes. Meat intake and percent energy from lipids were significantly positively correlated with the MCP-1 level, especially, stronger in A/A genotype. In the stepwise discriminant analysis, TNF-α level, meat intake, HDL-C were associated with MCP-1 in all subjects (model R2 = 24%). TNF-α level, sugar intake, cholesterol intake, and meat intake affected MCP-1 in A/A genotype (model R2 = 82%), but not in G/A or G/G. In conclusion, subjects possessing A/A genotype exhibited higher levels of MCP-1 than other genotypes in Korean elders. Further, meat, sugar, and cholesterol intakes affected the MCP-1 level. Therefore, the decrement of meat, sugar, and cholesterol intakes helps to normalize the MCP-1 level and can decrease CVD risk in A/A genotype.

Keywords: MCP-1; MCP-1 polymorphism; dietary factors; Korean elders


Fig. 1
The level of MCP-1 according to genotype in the subject with dyslipideamia and obese. ab: Different superscript letters indicate the comparison with significant differences according to MCP-1 genotypes within the same category by GLM test at p < 0.05.
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Fig. 2
The plasma MCP-1 level according to intake of meat (A), sugar (B), % energy from carbohydrate (C), % energy from lipid (D) by genotype. ab: Different superscript letters indicate the comparison with significant differences according to MCP-1 genotypes within the same category by GLM test at p < 0.05. *: Significant differences according to intake levels within the same genotypes by Student's t-test, p < 0.05.
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Table 1
Clinical characteristics of subjects based on MCP-1 polymorphism
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Table 2
Daily food intakes by food groups based on MCP-1 polymorphism
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Table 3
Daily nutrient intakes based on MCP-1 polymorphism
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Table 4
Immune variables based on MCP-1 polymorphism
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Table 5
Pearson's correlation coefficients between food intakes and plasma MCP-1 level
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Table 6
The result of discriminant analysis for factors related the MCP-1 level
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