Abstract
Dermatomyositis is a inflammatory myopathy associated with interstitial lung disease in 5∼10% of cases. The oc-currence of diffuse alveolar hemorrhage (DAH) is consid-ered exceptional in the course of dermatomyositis. We ex-perienced a case of DAH in a 58-year-old female with dermatomyositis. DAH was diagnosed by anemia, infiltration on chest X-ray and computed tomography, and a bloody aspirate on bronchoscopy. Combined Pneumocys-tis jiroveci (PJP) pneumonia was suspected, as the polymerase chain reaction for PJP was positive. After intravenous the administration of immunoglobulin and treatment for the PJP, she markedly improved but subsequently developed nosocomial pneumonia and died.
References
1. Dickey BF, Myers AR. Pulmonary disease in polymyositis/dermatomyositis. Semin Arthritis Rheum. 1984; 14:60–76.
3. Schwarz MI, Sutarik JM, Nick JA, Leff JA, Emlen JW, Tuder RM. Pulmonary capillaritis and diffuse alveolar hemorrhage. A primary manifestation of polymyositis. Am J Respir Crit Care Med. 1995; 151:2037–40.
4. Shoda T, Kotani T, Takeuchi T, Makino S, Hanafusa T. A fulminant case of systemic sclerosis/dermatomyositis complicating thrombotic microangiopathy and diffuse alveolar hemorrhage. Nihon Kokyuki Gakkai Zasshi. 2009; 47:227–31.
5. Omori CH, Jesus AA, Sallum AM, Adde FV, Rodrigues JC, Silva CA. Association between pulmonary hemosi-derosis and juvenile dermatomyositis. Acta Reumatol Port. 2009; 34:271–5.
6. Do-Pham G, Pagès C, Picard C, Galicier L, Lémann M, Dubertret L, et al. A first case report of a patient with paraneoplastic dermatomyositis developing diffuse alveolar haemorrhage. Br J Dermatol. 2010; 163:227–8.
7. Kim NY, Kim SG, Song YW, Han SK, Han JS, Lee JS, et al. Massive pulmonary hemorrhage in a patient with systemic lupus erythematosus. Seoul J Med. 1989; 30:195–201.
8. Hwang KW, Ahn YS, Moon JY, Kim IY, Park YE, Kim GT, et al. Experience of rituximab treatment in two patients with severe systemic lupus erythematosus. J Korean Rheum Assoc. 2006; 13:230–5.
9. Koh JH, Song SY, Lee CK, Seo GH, Ahn HJ, Cha HS, et al. A case of diffuse alveolar hemorrhage in systemic lupus erythematosus: treatment with plasmapheresis. J Korean Rheum Assoc. 1999; 6:185–91.
10. Ioachimescu OC, Stoller JK. Diffuse alveolar hemorrhage: diagnosing it and finding the cause. Cleve Clin J Med. 2008; 75:258–80.
12. Tanawuttiwat T, Harindhanavudhi T, Hanif S, Sahloul MZ. Amiodarone-induced alveolar haemorrhage: a rare complication of a common medication. Heart Lung Circ. 2010; 19:435–7.
13. Sheares KK, Mahadeva R. Recombinant factor VIIa and intravenous immunoglobulin therapy for diffuse alveolar haemorrhage: a cautionary tale? Respiratory Medicine Extra. 2005; 1:120–3.