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Hyun, Kang, Kim, Kim, Suh, and Cho: Establishment of a Research and Assessment System Using High Quality Non-Human Primates
Original Article

Lab. Anim. Res. 2010;26(4):449-457.

Published online: 20 January 2010

DOI: https://doi.org/10.5625/lar.2010.26.4.449

Establishment of a Research and Assessment System Using High Quality Non-Human Primates

Byung-Hwa Hyun1, ∗, Byeong-Cheol Kang2, Chuel-Kyu Kim3, Heui-Soo Kim4, Jun Gyo Suh5, Fumiaki Cho6

1Disease Model Animal Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

2Clinical Research Institute, Seoul National University Hospital, Seoul, Korea

3Laboratory Animal Research Team, National Institute of Food and Drug Safety Evaluation, Seoul, Korea

4Department of Biological Sciences, College of Natural Sciences, Pusan National University, Pusan, Korea

5Department of Medical Genetics, College of Medicine, Hallym University, Chuncheon, Korea

6Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Tsukuba, Japan

∗Corresponding author: Byung-Hwa Hyun, Disease Model Animal Center, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahangno, Yuseong-gu, Daejeon 305-333, Korea Tel: +82-42-860-4632 Fax: +82-42-860-4609 E-mail: hyunbh@kribb.re.kr

Received 9 November 2010       Revised 7 December 2010       Accepted 8 December 2010

Copyright © 2010 Korean Association for Laboratory Animal Science

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

At present, eight non-human primate research facilities exist in Korea to examine the validity and safety of new bio-products, and to generate model animal systems using primates of low health status (low quality primates). However specific-pathogen free (SPF) primates (high quality primates) are the preferred choice for emerging disease studies and for numerous other research areas, including cell/gene therapy, stem cell research, regenerative studies, and brain science. Although international primate centers in developed countries have utilized high quality primate resources for many years, there has been little or no collaboration with less developed countries on primate research. Due to this, the establishment of a high quality primate research capacity is a core priority for the advancement of the biomedical research field in less developed countries. In this study, we investigated the demand for, and opportunities to support the development of this research capability.

Keywords: Non-human primates, high quality primate, low quality primate, SPF

References

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Figure 1.
Annual number of primates imported into USA, Japan and Korea.
lar-26-449f1.tif
Figure 2.
Suitability of low and high quality primates for biomedical research.
lar-26-449f2.tif
Figure 3.
Fields of users on non-human primates using survey in Korea.
lar-26-449f3.tif
Figure 4.
Preferred approach for addressing international competition from existing high quality primate research centers.
lar-26-449f4.tif
Figure 5.
Critical roles for national demand and using with non-human primates.
lar-26-449f5.tif
Figure 6.
Priorities to be met by a high quality primate research system.
lar-26-449f6.tif
Figure 7.
Process for deriving SPF accredited macaques.
lar-26-449f7.tif
Figure 8.
Design concept for high quality primate research center.
lar-26-449f8.tif
Table 1.
Laboratory primate resources in developed countries
Name of primate centers Number of monkeys (species)
California National Primate Research Center (CNPRC), Davis, USA 3,535 monkeys (3)
New England National Primate Research Center (NEPRC), Southborough, USA 1,561 monkeys (9)
Oregon National Primate Research Center (ONPRC), Beaverton, USA 4,050 monkeys (3)
Southwest National Primate Research Center (SNPRC), San Antonio, USA 3,900 monkeys and 230 chimpanzees (6)
Tulane National Primate Research Center (TNPRC), Covington, USA 3,642 monkeys (13)
Washington National Primate Research Center (WaNPRC), Seattle, USA 4,501 monkeys (4)
Wisconsin National Primate Research Center (WNPRC), Madison, USA 1,220 monkeys (3)
Yerkes National Primate Research Center (YNPRC), Atlanta, USA 2,500 monkeys (9)
Tsukuba Primate Research Center (TPRC), Tsukuba, Japan 1,600 monkeys (2)∗
Primate Research Institute, Kyoto University (KUPRI), Inuyama, Japan 850 monkeys and apes (20)
Research Center for Animal Life Science (RCALS), Shiga, Japan 720 monkeys (1)∗
German Primate Center (DPZ), Göttingen, Germany 1,265 monkeys (8)

∗ only indoor

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