The Effect of Food Restriction on Appetite Regulating Hormones and Adiponectin Activity

Ki Hoon Kim; Hyun Kook Kim

doi:10.4163/kjn.2012.45.1.5

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Kim and Kim: The Effect of Food Restriction on Appetite Regulating Hormones and Adiponectin Activity

Research Article

Korean Journal of Nutrition

Korean Journal of Nutrition 2012; 45(1): 5-11.

Published online: 29 February 2012

DOI: https://doi.org/10.4163/kjn.2012.45.1.5

The Effect of Food Restriction on Appetite Regulating Hormones and Adiponectin Activity

Ki Hoon Kim¹, Hyun Kook Kim²

¹Department of Leisure Sports, Kyunpook National University, Sangju 742-711, Korea.

²Department of Physical Education, Daegu University, Gyoungsan 712-714 Korea.

To whom correspondence should be addressed. (kimhk730@naver.com)

Received 31 October 2011 Revised 23 December 2011 Accepted 26 December 2011

Abstract

We investigated the effects of short-term food restriction and repeated fasting and refeeding on appetite regulating hormones and adiponectin activity in rats. To investigate the acute and chronic effects of food restriction in vivo, Sprague-Dawley rats were divided into a control group (CON), a 1 day fasting group, a 2 days fasting gruop, a 3 days fasting gruop, a fasting and refeeding for 1 week gruoup and a fasting and refeeding for 2 weeks group. Blood glucose, triglyceride and total cholesterol decreased in all fasting groups compared to those in the CON group. Free fatty acid of all fasting groups was higher than those in the CON, and were lowest in the three cycle fasting and refeeding group. Blood insulin following short-term food restriction was lower than that in the CON. blood ghrelin increased significantly (p < 0.01) following the short-term food restriction, However, blood ghrelin in the repeated fasting and refeeding groups decreased significantly decreased (p < 0.01) compared to that in the CON and short-term food restriction group. In contrast, blood leptin decreased significantly (p < 0.01) in the short term food restriction group and the three cycle of fasting and refeeding group but increased in the six cycle of fasting and refeeding group. No significant differences in adiponectin contents were observed in the short-term food restriction group. But, adiponectin increased significantly (p < 0.01) following the fasting and refeeding cycles. Blood adiponectin and blood leptin levels were showed positively correlated (r² = 0.469) when all samples were analysed together.

Keywords: adiponectin, food restriction, repeated fasting and refeeding

Figures and Tables

Fig. 1

Correlation of the adiponectin and leptin.

Fig. 2

Correlation of the adiponectin and the ghrelin.

Table 1

Change of plasma concentration in the experimental groups

Values are mean ± S.D.

a) p < 0.05 vs. CON b) p < 0.05 vs. F1D c) p < 0.05 vs. F2D d) p < 0.05 vs. F3D e) p < 0.05 vs. FR1W

CON: control, F1D: fasting for 1 day, F2D: fasting for 2 days, F3D: fasting for 2 days, FR1W: fasting and re-feeding for 1 week, FR2W: fasting and re-feeding for 2 weeks

Table 2

Change of appetite control hormone concentration in the experimental groups

Values are mean ± S.D.

a) p < 0.05 vs. CON b) p < 0.05 vs. F1D c) p < 0.05 vs. F2D d) p < 0.05 vs. F3D e) p < 0.05 vs. FR1W

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