The effect of medicinal herb administration to arthritis inducded rabbit arthritistreatment

Tae Dong Kwon; Ki Hoon Kim

doi:10.4163/kjn.2012.45.5.437

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Kwon and Kim: The effect of medicinal herb administration to arthritis inducded rabbit arthritistreatment

Research Article

Korean Journal of Nutrition

Korean Journal of Nutrition 2012; 45(5): 437-442.

Published online: 31 October 2012

DOI: https://doi.org/10.4163/kjn.2012.45.5.437

The effect of medicinal herb administration to arthritis inducded rabbit arthritistreatment

Tae Dong Kwon, Ki Hoon Kim

Department of Leisure Sport, Kyungpook National University, Sangju 742-711, Korea.

To whom correspondence should be addressed. (tdkwon6086@hanmail.net)

Received 10 September 2012 Revised 22 September 2012 Accepted 26 September 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study was is to investigate the arthritis treatment and prevention of the effects the herbral administration to experimental animals induces arthritis 4 weeks for medicinal herbs (Scutellaria baicalensis Georgi, Acanthopanacis cortex, Achyranthis Radix). To investigate the prevention of histopathological examination and molecular biological examinations for arthritis improvement in vivo New Zealand, white rabbits were divided into a normal (Normal, n = 7), or a collagen-induced arthritis (CIA, n = 7), or a collagenase injection and medicinal herbs (SAA, n = 7). It was confirmed that induced arthritis was treated with Gross examination, and the measurement of average arthritis index (MAI) and improved arthritis by medicinal herbs. TNF-α and IL-1β were significantly increased in the CIA and SAA groups, compared to the normal group (p < 0.05). MMP-1 and TIMP-2 were significantly increased in the CIA, compared to the other groups (p < 0.05). MMP-1 and TIMP-2 were significantly decreased in the SAA group, compared to the CIA group (p < 0.05). As a result, Herbal administration used in this study might be able to help in the treatment of arthritis induced by inflammatory and immunosuppressive effects, that which can be expected.

Keywords: medicinal herbs, arthritis, inflammatory

Figures and Tables

Fig. 1

The collagenase injectioned knee of rabbit (arrow) was more swollen compared with the other knee.

Fig. 2

Immunohistochmical stain of knee joints (TB protocol, ×400).

Fig. 3

The concentration of TNF-α (A) and IL-1β (B) in the blood of rabbits after 4 weeks treatment of each samples. a: p < .05 vs. normal.

Fig. 4

The concentration of MMP-1 (A) and TIMP-2 (B) in the synovial fluids of Rabbits after 4 weeks treatment of each samples. a: p < .05 vs. Normal, b: p < .05 vs. CIA.

Table 1

Change of mean arthritic index (MAI)

^***: p < .001. B = CIA, C = SAA. CIA: Collagen-induced arthritis, SAA: Scutellaria/Acanthopanax/Achyranthis Radix induce

Notes

This Research was supported by Kyungpook National University Research Fund, 2010.

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