Selenium Status and Glutathione Peroxidase Activity in Korean Infants

Hyun-Ha Kim; Hye-Ran Yang; Hye-Young P. Kim

doi:10.4163/kjn.2011.44.2.112

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Kim, Yang, and Kim: Selenium Status and Glutathione Peroxidase Activity in Korean Infants

Research Article

Korean Journal of Nutrition

Korean Journal of Nutrition 2011; 44(2): 112-118.

Published online: 30 April 2011

DOI: https://doi.org/10.4163/kjn.2011.44.2.112

Selenium Status and Glutathione Peroxidase Activity in Korean Infants

Hyun-Ha Kim¹, Hye-Ran Yang², Hye-Young P. Kim¹

¹Department of Food and Nutrition, Yongin University, Yongin 449-714, Korea.

²Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam 463-707, Korea.

To whom correspondence should be addressed. (hypkim@yongin.ac.kr)

Received 28 January 2011 Revised 19 March 2011 Accepted 23 March 2011

Abstract

We investigated the selenium (Se) nutrition status in Korean infants. The mean serum Se concentration in infants was 66.9 µg/L, and it increased with increasing in infant age: 57.6 µg/L at 0-5 months, 71.8 µg/L at 6-11 months, and 75.5 µg/L at 12-24 months. Serum glutathione peroxidase (GPx) activity also increased with infant age. Serum Se concentration in infants was positively correlated with serum GPx activity (r = 0.565, p < 0.01). At 0-5 months, human milk-fed infants tended to have higher Se concentrations and GPx activity than those of formula-fed infants, but the result was not significant. With the introduction of supplemental feeding at 6-24 months of age, serum Se concentration was not different between the groups. Therefore, human milk feeding seemed to be more appropriate for infant Se nutrition than infant formula feeding during the first 6 months of life, but supplemental feeding became more important later to maintain good Se nutrition status.

Keywords: infant, selenium, glutathione peroxidase, human milk, formula

Figures and Tables

Fig. 1

Relationship between serum selenium concentration and glutathione peroxidase activity of infants (r = 0.565, p < 0.01).

Table 1

General characteristics of the infant

1) number (%), 2) Mean ± SD, 3) in each column not sharing a common superscript differ by Duncan's multiple range test (p < 0.05)

Table 2

Serum selenium concentration and glutathione peroxidase activities of the infant

1) Mean ± SD, 2) in each column not sharing a common superscript differ by Duncan's multiple range test (p < 0.05)

Table 3

Serum selenium concentration (µg/L) by feeding method during first 6 months

1) Mean ± SD, 2) Result of two-way ANOVA by age and feeding method. A: effect of age, M: effect of feeding method, A*M: interaction of age and feeding method, 3) NS: not significantly different by independent t-test between human milk and formula feeding group at same age group

Table 4

Serum glutathione peroxidase activity (U/L) by feeding method during first 6 months

Notes

This research was supported by National Research Foundation of Korea Grant funded by the Korean Government (531-2008-1-C00077).

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