Journal List > Korean J Nutr > v.43(6) > 1043851

Korean J Nutr. 2010 Dec;43(6):561-569. Korean.
Published online December 31, 2010.  https://doi.org/10.4163/kjn.2010.43.6.561
© 2010 The Korean Nutrition Society
Antihypertensive Properties of Dried Radish Leaves Powder in Spontaneously Hypertensive Rats
Bo Ram Kim,1 Ji Ho Park,1 Sun-Hee Kim,1 Kang Jin Cho,2 and Moon-Jeong Chang1
1Department of Food & Nutrition, Kookmin University, Seoul 136-702, Korea.
2Department of Functional Food & Nutrition Division, Rural National Academy of Agricultural Science, Suwon 441-707, Korea.

To whom correspondence should be addressed. (Email: cmoon@kookmin.ac.kr )
Received November 05, 2010; Revised November 15, 2010; Accepted November 25, 2010.

Abstract

The study aim was to investigate the antihypertensive effect after oral supplementation of dried radish leaves powder (DRLP). Angiotensin-converting enzyme (ACE) activity was measured by spectrophotometric assay. The systolic blood pressure (SBP) was measured in spontaneously hypertensive (SHR) and normotensive rats (Wistar) by the tail cuff method after a 4-week diet with DRLP at the level of 2.5% or 5%. The supplementation of DRLP decreased SBP of SHR although the 5% supplementation level did not show any more pronounced effect than the 2.5% level did. The decrease in the SBP observed for both 2.5% and 5% DRLP was accompanied by significant increases of the urinary Na and K excretion. The DRLP supplementation showed a potent ACE-inhibitory activity in pulmonary tissue from both hypertensive and normotensive rats. However, the DRLP supplementation did not affect the SBP in normotensive rats. These results indicated that DRLP exerted an antihypertensive effect in SHR due to the decreased ACE activity and increased urinary Na excretion.

Keywords: dried radish leaves powder; blood pressure; angiotensin converting enzyme activities; hypertension

Tables


Table 1
Composition of experimental diets
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Table 2
The concentration of total flavonoids and total phenols in dried radish leaves and various fruits (mg/100 g)
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Table 3
Total food intake, initial body weight, body weight gain and food efficiency ratio (FER)
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Table 4
Systolic blood pressure of experimental rats
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Table 5
Effect of dried radish leaves powder on ACE activities
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Table 6
Effect of radish leaf powder on GABA concentration in brain and serum
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Table 7
Effect of radish leaf powder on urine constituent
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Notes

This research was supported by 15 agenda research project from Rural Development Administration (project No. PJ0067-062010).

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