Youn-Ok Cho

doi:10.4163/kjn.2010.43.3.315

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Cho: Vitamin B6 Requirement: Indicators and Factors Affecting∗

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Korean J Nutr 2010;43(3):315-323.

Published online: 8 January 2010

DOI: https://doi.org/10.4163/kjn.2010.43.3.315

Vitamin B₆ Requirement: Indicators and Factors Affecting^∗

Youn-Ok Cho^§,

Department of Food and Nutrition, Ducksung Women's University, Seoul 132-714, Korea

^∗ This research was support by a grant (09082KFDA042) from Korea Food & Drug Administration in 2009.

^§To whom correspondence should be addressed. E-mail: yunokcho@duksung.ac.kr

Revised 9 April 2010

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study was to establish the selection of indicators for estimating and factors affecting the requirement of vitamin B6. There has been a need to establish the human requirements of vitamin B₆ since vitamin B₆ is thought to be involved in more than one hundred biochemical reactions as a coenzyme in the metabolism of amino acids, glucose, and lipid, and the synthesis of neurotransmitters. For the review of the literature, this study included from early findings of the sixties to studies of 2009. This study suggests that plasma pyridoxal 5’ phosphate (PLP) is the best single indicator of vitamin B₆ status for the healthy but not for the non-healthy. Erythrocyte aspartate aminotransferase and alanine aminotransferase activation by PLP as an indirect measure and urinary 4-pyridoxic acid excretion as a direct measure are useful as supporting indicators. Bioavailability, nutrient interaction, physiological need, and chronic diseases may increase the requirement for vitamin B₆. However, these effects can not be quantified due to insufficient evidences.

Keywords: vitamin B₆ requirement, vitamin B₆ status, vitamin B₆ indicator, vitamin B₆ DRI

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