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Abstract
Sasa borealis leaf has been known to have anti-diabetic properties. In this study, we tried to evaluate the effects of Sasa borealis leaf extract (SBE) on the inhibition of α-glucosidase activity and postprandial glycemic response following ingestion of four carbohydrate-rich foods; cooked rice, ramen (instant noodle), noodle, and bread. Fourteen healthy female adults consumed 50 g of glucose (control) or one of the four foods containing 50 g of available carbohydrate with or without 2,000 mg of SBE. The activity of α-glucosidase was inhibited dose-dependently by SBE. With SBE, blood glucose concentration at 15 min and the positive area under the curve (AUC) of postprandial glycemic response at 15 min and 30 min after consuming each of the four foods were reduced significantly. As the result, total positive AUC during 120 min was decreased in case of taking cooked rice or bread. Glycemic index and glycemic load of the four foods were declined from 13% to 23% with SBE. The results of this study suggest that SBE may be effective for postprandial glucose control by inhibiting α-glucosidase activity.
Figures and Tables
Fig. 1
Inhibition of α-glucosidase activity by Sasa borealis leaf extract. Values are mean ± standard deviation.
Fig. 2
Incremental concentration of blood glucose after consuming glucose or each of 4 test foods. Values with different lowercase superscripts at the same time are significantly different among glucose and 4 test foods at p < 0.05 by ANOVA with Duncan's multiple range test. Incremental concentration of blood glucose was calculated by subtracting the value of fasting blood glucose from the value at each time.
Fig. 3
Effect of Sasa borealis leaf extract on incremental blood glucose concentration after consuming glucose or each of 4 test foods. Values with different asterisk at the same time are significantly different at p < 0.05 by Paired t-test.
Fig. 4
Percent change of glycemic index (GI) and glycemic load (GL) of 4 test foods by Sasa borealis leaf extract. Values with asterisks are significantly lower than the data without Sasa borealis leaf extract at p < 0.05.
Table 4
Area under the curve (AUC) after consuming glucose or each of 4 test foods with and without Sasa borealis leaf extract
Values with different lowercase superscripts in the column are significantly different among glucose and 4 test foods at p < 0.05 by ANOVA with Duncan's multiple range test. Values with asterisks at the same time are significantly different by paired t-test. *: p < 0.05, **: p < 0.01. SBE: 2000 mg of Sasa borealis leaf extract
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