Acquired hemophilia due to the acquisition of antibodies to factor VIII is quite rare, and is associated with conditions such as pregnancy, lymphoma and autoimmune disorders. However, surgical trauma has not been recognized as a cause of factor VIII inhibitors. There have only been 4 cases (3 abdominal surgery, 1 coronary bypass surgery) reported in the world thus far. We experienced acquired hemophilia associated with Total Knee Arthroplasty. This syndrome presents with abrupt bleeding in the first few days after surgery and may cause life-threatening complications. We report a case of acquired hemophilia that was cured with immunosuppressive therapy with a review of the relevant literature.