Journal List > Korean J Lab Med > v.30(6) > 1011690

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Korean J Lab Med. 2010 Dec;30(6):547-553. Korean.
Published online December 02, 2010.  https://doi.org/10.3343/kjlm.2010.30.6.547
Copyright © 2010 The Korean Society for Laboratory Medicine
Prognostic Impact of Helicobacter pylori Infection and Eradication Therapy in Gastric Mucosa-associated Lymphoid Tissue Lymphoma
Sang Hyuk Park, M.D.,1 Hyun-Sook Chi, M.D.,1 Seo-Jin Park, M.D.,1 Seongsoo Jang, M.D.,1 Chan-Jeoung Park, M.D.,1 and Joo Ryung Huh, M.D.2
1Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
2Department of Pathology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.

Corresponding author: Hyun-Sook Chi, M.D. Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine, 388-1 Pungnap-2-dong, Songpa-gu, Seoul 138-736, Korea. Tel: +82-2-3010-4502, Fax: +82-2-478-0884, Email: hschi@amc.seoul.kr
Received April 26, 2010; Revised August 27, 2010; Accepted October 07, 2010.

Abstract

Background

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is associated with Helicobacter pylori infection and H. pylori eradication is used as its first-line therapy. However, controversies exist about the prognostic value of H. pylori infection in these patients. We evaluated the prognostic impact of H. pylori infection and eradication therapy in gastric MALT lymphoma.

Methods

A total of 292 patients diagnosed with MALT lymphoma since 2000 were analysed. MALT lymphoma was diagnosed with tissue biopsy and H. pylori infection was diagnosed with hematoxylin-eosin and additional Warthin-Starry stains on tissue sections. Clinical variables such as bone marrow (BM) involvement, multiorgan involvement, tumor stage at diagnosis, and remission were obtained with retrospective review of electronic medical records.

Results

Non-gastric MALT lymphoma patients showed higher multiorgan involvement rates (26.6% vs. 9.6%, P<0.001) and higher proportion of stage ≥3 (27.7% vs. 16.7%, P=0.029) than gastric cases. Regarding gastric MALT lymphoma, patients with H. pylori infection at diagnosis showed significantly less BM (2.1% vs. 21.8%, P<0.001) and multiorgan involvement rates (6.3% vs. 18.2%, P=0.011) than those without infection. But there was no significant difference in remission rates between them. In contrast, those with successful H. pylori eradication therapy showed significantly higher remission rates (81.0% vs. 30.8%, P<0.001) than those with failure.

Conclusions

Non-gastric MALT lymphoma patients showed worse prognosis compared to gastric cases. As for remission rates in patients with gastric MALT lymphoma, successful H. pylori eradication therapy could be a good prognostic factor even if H. pylori infection was present at diagnosis.

Keywords: MALT lymphoma; Helicobacter pylori; Prognosis

Tables


 Table 1
Clinical features of 292 MALT lymphoma patients according to primary sites
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Table 2
Comparison of clinical features according to Helicobacter pylori infection at diagnosis and its eradication in patients with gastric MALT lymphoma
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Table 3
Univariate analysis of remission in patients with gastric MALT lymphoma according to various clinical variables
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Table 4
Multivariate analysis of remission in patients with gastric MALT lymphoma according to various clinical variables
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