Journal List > J Korean Neuropsychiatr Assoc > v.54(3) > 1017746

Yoo, Heo, Kim, Baek, Yoo, Kim, and Jeon: Comparisons of Depressive Symptoms of the Hamilton Depression Rating Scale between Elderly and Non-Elderly Outpatients with Major Depressive Disorder

Abstract

Objectives

Previous studies have reported that symptoms of patients with major depressive disorder (MDD) are different according to age groups, and the Hamilton Depression Rating Scale (HDRS) is the most widely used measure to evaluate the symptoms of MDD. However, few previous studies have compared the symptoms of HDRS between the elderly and non-elderly groups.

Methods

The study population consisted of 574 subjects with MDD who were ≥18 years old, evaluated using the Mini International Neuropsychiatric Interview and 17 items of HDRS. Differences between two groups were analyzed using independent t-test. A multivariate logistic regression model was used to evaluate associations between age and 17 items from HDRS after controlling for gender, years of education, marital status, and employment status.

Results

Among 574 patients with MDD, there were 80 elderly patients (age≥65) and 494 non-elderly patients (age between 18 and 64). Elderly patients had higher scores on item 5 (middle insomnia) (t=-2.271, p=0.024) and item 6 (late insomnia) (t=-2.280, p=0.023), whereas they had lower scores on item 1 (depressed mood) (t=2.860, p=0.004), item 3 (suicide) (t=2.258, p=0.024), and item 9 (agitation) (t=2.031, p=0.043), although no significant difference in the total HDRS scores was observed between elderly and non-elderly. Multivariate logistic regression showed significant association of elderly with hypochondriasis [adjusted odds ratio (AOR)=1.894, 95% confidence interval (CI) 1.01-3.56] and agitation (AOR=0.50, 95% CI 0.29-0.87).

Conclusion

Elderly MDD patients showed more insomnia and hypochondriasis and less depressed mood, suicidal ideation, and agitation than non-elderly.

Figures and Tables

Fig. 1

Mean scores of each item of the Hamilton Depression Rating Scale by age groups.

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Table 1

Demographic and clinical profiles of the subjects (n=574)

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* : Housewives were excluded, : p-value from univariate analysis. HDRS : Hamilton Depression Rating Scale, MDQ : Mood Disorder Questionnaire, HCL-32 : Hypomania/Mania Symptom Checklist 32

Table 2

Comparison of HDRS items between non-elderly and elderly group

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* : p<0.05. HDRS : Hamilton Depression Rating Scale

Table 3

Multivariate logistic regression analysis for relative odds ratio of each depressive symptom according to age

jkna-54-316-i003

Adjusted for gender, years of education, employment status, and marital status. * : p<0.05, : Number of subjects who have each depression symptom among total subjects. AOR : Adjusted odds ratio, CI : Confidence interval, HDRS : Hamilton Depression Rating Scale

Notes

Conflicts of Interest The authors have no financial conflicts of interest.

References

1. Cho MJ, Park JI, Bae A, Bae JN, Sohn JW, Ahn JH, et al. The epidemiological survey of mental disorders in Korea [Internet]. Seoul: Seoul National University College of Medicine;2011. cited 2014 Oct 6. Available from: http://www.google.co.kr/url?sa=t&rct=j&q=&esrc=s&frm=1&source=web&cd=1&ved=0CCIQFjAA&url=http%3A%2F%2Fstat.mw.go.kr%2Ffront%2Finclude%2Fdownload.jsp%3FbbsSeq%3D13%26nttSeq%3D18458%26atchSeq%3D3026&ei=shYqVJKXEoeE8gWkk4GADg&usg=AFQjCNGSD11Yht8HJQLZnkYnvaRS14aYlQ&bvm=bv.76477589,d.dGc&cad=rjt.
2. Parkar SR. Elderly mental health: needs. Mens Sana Monogr. 2015; 13:91–99.
crossref
3. Sadock BJ, Sadock VA, Ruiz P. Kaplan and Sadock's Synopsis of Psychiatry: behavioral sciences/clinical psychiatry. 11th ed. Philadelphia, PA: Wolters Kluwer Health;2014.
4. Arai H, Ouchi Y, Yokode M, Ito H, Uematsu H, Eto F, et al. Toward the realization of a better aged society: messages from gerontology and geriatrics. Geriatr Gerontol Int. 2012; 12:16–22.
crossref
5. Lebowitz BD, Pearson JL, Schneider LS, Reynolds CF 3rd, Alexopoulos GS, Bruce ML, et al. Diagnosis and treatment of depression in late life. Consensus statement update. JAMA. 1997; 278:1186–1190.
crossref
6. Lyness JM, Cox C, Curry J, Conwell Y, King DA, Caine ED. Older age and the underreporting of depressive symptoms. J Am Geriatr Soc. 1995; 43:216–221.
crossref
7. Gottfries CG. Is there a difference between elderly and younger patients with regard to the symptomatology and aetiology of depression? Int Clin Psychopharmacol. 1998; 13:Suppl 5. S13–S18.
crossref
8. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. 5th ed. Washington, DC: American Psychiatric Association;2013.
9. VanItallie TB. Subsyndromal depression in the elderly: underdiagnosed and undertreated. Metabolism. 2005; 54:5 Suppl 1. 39–44.
crossref
10. Beheydt LL, Schrijvers D, Docx L, Bouckaert F, Hulstijn W, Sabbe B. Psychomotor retardation in elderly untreated depressed patients. Front Psychiatry. 2015; 5:196.
crossref
11. Shahpesandy H. Different manifestation of depressive disorder in the elderly. Neuro Endocrinol Lett. 2005; 26:691–695.
12. Cole MG, Dendukuri N. Risk factors for depression among elderly community subjects: a systematic review and meta-analysis. Am J Psychiatry. 2003; 160:1147–1156.
crossref
13. Tan LL, Ng LL, Tan S, Roy K, Brodaty H, Parker G. Depression in Singapore: failure to demonstrate an age effect on clinical features. Int J Geriatr Psychiatry. 2001; 16:1054–1060.
crossref
14. Hong SW, Lee DS, Jae YM, Jang SH, Choi JH, Jang YK, et al. Comparison of Depressive Symptoms of Major Depressive Disorder between Elderly and Non-Elderly Group in Busan City in South Korea. J Korean Soc Biol Ther Psychiatry. 2008; 14:58–63.
15. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1967; 6:278–296.
crossref
16. Hirschfeld RM, Williams JB, Spitzer RL, Calabrese JR, Flynn L, Keck PE Jr, et al. Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder Questionnaire. Am J Psychiatry. 2000; 157:1873–1875.
crossref
17. Angst J, Adolfsson R, Benazzi F, Gamma A, Hantouche E, Meyer TD, et al. The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatients. J Affect Disord. 2005; 88:217–233.
crossref
18. Oh MY, Angst J, Sung TH, Lee EH, Hong KS, Lee DS, et al. Reliability and validity of the Hypomania Symptom Checklist-32 in Korea. Korean J Clin Psychol. 2009; 28:321–338.
crossref
19. Jon DI, Hong N, Yoon BH, Jung HY, Ha K, Shin YC, et al. Validity and reliability of the Korean version of the Mood Disorder Questionnaire. Compr Psychiatry. 2009; 50:286–291.
crossref
20. Salzman C. Pharmacologic treatment of depression in the elderly. J Clin Psychiatry. 1993; 54:Suppl. 23–28.
21. Livingston G, Watkin V, Milne B, Manela MV, Katona C. The natural history of depression and the anxiety disorders in older people: the Islington community study. J Affect Disord. 1997; 46:255–262.
crossref
22. Sloan EP, Flint AJ, Reinish L, Shapiro CM. Circadian rhythms and psychiatric disorders in the elderly. J Geriatr Psychiatry Neurol. 1996; 9:164–170.
crossref
23. Leblanc MF, Desjardins S, Desgagné A. The relationship between sleep habits, anxiety, and depression in the elderly. Nat Sci Sleep. 2015; 7:33–42.
24. Leblanc MF, Desjardins S, Desgagné A. Sleep cognitions associated with anxiety and depression in the elderly. Clin Interv Aging. 2015; 10:575–582.
25. Lôo H, Gallarda T, Fabre I, Olié JP. [Depression and aging]. Bull Acad Natl Med. 2004; 188:999–1007. discussion 1007-1010
26. DeLamater J, Karraker A. Sexual functioning in older adults. Curr Psychiatry Rep. 2009; 11:6–11.
crossref
27. Lyness JM, Kim J, Tang W, Tu X, Conwell Y, King DA, et al. The clinical significance of subsyndromal depression in older primary care patients. Am J Geriatr Psychiatry. 2007; 15:214–223.
crossref
28. Small GW. Differential diagnoses and assessment of depression in elderly patients. J Clin Psychiatry. 2009; 70:e47.
crossref
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