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Song: EUCAST v.12.0 review focused on changes
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Ann Clin Microbiol 2022;25(3):67-72.

Published online: 20 September 2022

DOI: https://doi.org/10.5145/ACM.2022.25.3.1

EUCAST v.12.0 review focused on changes

Sae Am Song

Department of Laboratory Medicine, Inje University College of Medicine, Busan, Korea

Corresponding author: Sae Am Song E-mail: songsaeam@paik.ac.kr

Received 4 August 2022       Revised 11 August 2022       Accepted 11 August 2022

© Korean Society of Clinical Microbiology. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Clinical and Laboratory Standards Institute and European Committee on Antimicrobial Susceptibility Testing (EUCAST) clinical breakpoint tables are commonly used as guidelines for the interpretation of antimicrobial susceptibility testing results. These are updated annually to reflect new and revised antimicrobial susceptibility breakpoints. EUCAST v.12.0, which was published in January 2022, presents updated meropenem-vaborbactam breakpoints for Enterobacterales and Pseudomonas aeruginosa. It also suggests new breakpoints of susceptibility to various antibiotics for Vibrio spp. Flow charts were updated for Streptococcus pneumoniae and Haemophilus influenzae, and the breakpoints for anaerobic bacteria were divided according to each species. Furthermore, recommendations were made for cases without antimicrobial susceptibility testing breakpoints and links to several rationale and guidance documents were provided for technical convenience.

Keywords: Antimicrobial susceptibility testing, Breakpoint, EUCAST v.12.0

[in Korean]

Ethics statement

It is not a human population study; therefore, approval by the institutional review board or the obtainment of informed consent is not required.

Conflicts of interest

No potential conflicts of interest relevant to this article were reported.

Funding

None.

REFERENCES

1. European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 12.0. https://www.eucast.org/clinical_ breakpoints/ [Online] (last visited on 31 July 2022). .

Table 1
New meropenem-vaborbactam breakpoints in Enterobacterales, P.aeruginosa
ACM-2503-01-t1.png

Abbreviations: S, susceptible; R, resistance; ATU, area of technical uncertainly .

Table 2
New EUCAST v.12.0 clinical breakpoint organism-antimicrobial agent for anaerobic bacteria
ACM-2503-01-t2.png

Abbreviation: EUCAST, European Committee on Antimicrobial Susceptibility Testing.

Table 3
Revised EUCAST v.12.0 clinical breakpoints
ACM-2503-01-t3.png

The revised part is indicated in bold type. Breakpoints in brackets are based on epidemiological cut-off.

Abbreviations: EUCAST, European Committee on Antimicrobial Susceptibility Testing; ATU, area of technical uncertainly; S, susceptible; R, resistance; MIC, minimal inhibitory concentration.

Fig. 1.
Flow chart based on the oxacillin screen test for S.pneumoniae. MIC, minimal inhibitory concentration (This figure has been produced in part under ECDC service contracts and made available by EUCAST at no cost to the user and can be accessed on the EUCAST website www. eucast.org.)
ACM-2503-01-f1.png
Fig. 2.
Flow chart based on the benzylpenicillin screen test for H. influenzae (This figure has been produced in part under ECDC service contracts and made available by EUCAST at no cost to the user and can be accessed on the EUCAST website www.eucast.org.)
ACM-2503-01-f2.png
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