Journal List > Ann Clin Microbiol > v.24(4) > 1516086620

TOOLS
Lee: Challenges of Scaling Up SARS-CoV-2 Rapid Antigen Tests
Original Article

Ann Clin Microbiol 2021;24(4):111-114.

Published online: 30 December 2021

DOI: https://doi.org/10.5145/ACM.2021.24.4.1

Challenges of Scaling Up SARS-CoV-2 Rapid Antigen Tests

Mi-Kyung Lee1

1Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea

Corresponding author: Mi-Kyung Lee E-mail: cpworld@cau.ac.kr

Received 30 December 2020       Revised 13 April 2021       Accepted 6 June 2021

© Korean Society of Clinical Microbiology. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.

Abstract

The current reference standard for the diagnosis of coronavirus disease 2019 (COVID-19) is the molecular detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Several rapid antigen tests (RATs) have been developed for the rapid and inexpensive detection of SARS-CoV-2, which can be used at the point-of-care. Although RATs have lower SARS-CoV-2 detection sensitivity than molecular tests, the development of a more cost-effective high-throughput test system that offers a rapid turnaround time is vital for curtailing the spread of SARS-CoV-2. However, because of the growing concern over the substantial risk of false negative results, RATs should be used in conjunction with molecular tests and therefore, an appropriate test algorithm should be developed to achieve this purpose.

Keywords: Rapid antigen tests, SARS-CoV-2

CONFLICTS OF INTEREST

No potential conflicts of interest relevant to this article were reported.

REFERENCES

1. Mattiuzzi C, Henry BM, Lippi G. Making sense of rapid antigen testing in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostics. Diagnosis 2021;8:27-31.
2. Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DK, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Eurosurveillance 2020;25:2000045. .
3. Mak GCK, Cheng PKC, Lau SSY, Wong KKY, Lau CS, Lam ETK, et al. Evaluation of rapid antigen test for detection of SARS-CoV-2 virus. J Clin Virol 2020;129:104500.
4. Mak GCK, Lau SSY, Wong KKY, Chow NLS, Lau CS, Lam ETK, et al. Evaluation of rapid antigen detection kit from the WHO Emergency Use List for detecting SARS-CoV-2. J Clin Virol 2021;134:104712.
5. Lambert-Niclot S, Cuffel A, Le Pape S, Vauloup-Fellous C, Morand-Joubert L, Roque-Afonso AM, et al. Evaluation of a rapid diagnostic assay for detection of SARS-CoV-2 antigen in nasopharyngeal swabs. J Clin Microbiol 2020;58:e00977-20.
6. Lippi G, Henry BM, Sanchis-Gomar F. Potential drawbacks of frequent asymptomatic coronavirus disease 2019 (COVID-19) testing. Infect Control Hosp Epidemiol 2020:1-2.
7. Walsh KA, Spillane S, Comber L, Cardwell K, Harrington P, Connell J, et al. The duration of infectiousness of individuals infected with SARS-CoV-2. J Infect 2020;81:847-56.
8. Bai AD, Li XX, Alsalem M, Khan S, Smieja M, Mertz D, et al. Utility of asymptomatic inpatient testing for COVID-19 in a low-prevalence setting: a multicenter point-prevalence study. Infect Control Hosp Epidemiol 2020;41:1233-5.
9. Müller M, Derlet PM, Mudry C, Aeppli G. Testing of asymptomatic individuals for fast feedback-control of COVID-19 pandemic. Phys Biol 2020;17:065007.
10. Surkova E, Nikolayevskyy V, Drobniewski F. False-positive COVID-19 results: hidden problems and costs. Lancet Respir Med 2020;8:1167-8.
11. Eckbo EJ, Locher K, Caza M, Li L, Lavergne V, Charles M. Evaluation of the BioFire® COVID-19 test and Respiratory Panel 2.1 for rapid identification of SARS-CoV-2 in nasopharyngeal swab samples. Diagn Microbiol Infect Dis 2021;99:115260.
12. Loeffelholz MJ, Alland D, Butler-Wu SM, Pandey U, Perno CF, Nava A, et al. Multicenter evaluation of the cepheid Xpert Xpress SARS-CoV-2 test. J Clin Microbiol 2020;58:e0092620.
13. Cerutti F, Burdino E, Milia MG, Allice T, Gregori G, Bruzzone B, et al. Urgent need of rapid tests for SARS CoV-2 antigen detection: evaluation of the SD-Biosensor antigen test for SARS-CoV-2. J Clin Virol 2020;132:104654.
14. Liotti FM, Menchinelli G, Lalle E, Palucci I, Marchetti S, Colavita F, et al. Performance of a novel diagnostic assay for rapid SARS-CoV-2 antigen detection in nasopharynx samples. Clin Microbiol Infect 2021;27:487-8.
15. Fenollar F, Bouam A, Ballouche M, Fuster L, Prudent E, Colson P, et al. Evaluation of the Panbio COVID-19 rapid antigen detection test device for the screening of patients with COVID-19. J Clin Microbiol 2020;59:e02589-20.
16. Weitzel T, Legarraga P, Iruretagoyena M, Pizarro G, Vollrath V, Araos R, et al. Comparative evaluation of four rapid SARS-CoV-2 antigen detection tests using universal transport medium. Travel Med Infect Dis 2021;39:101942.
17. Buitrago-Garcia D, Egli-Gany D, Counotte MJ, Hossmann S, Imeri H, Ipekci AM, et al. Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: a living systematic review and meta-analysis. PLoS Med 2020;17:e1003346.
18. Walsh KA, Jordan K, Clyne B, Rohde D, Drummond L, Byrne P, et al. SARS-CoV-2 detection, viral load and infectivity over the course of an infection. J Infect 2020;81:357-71.
19. WHO. Antigen-detection in the diagnosis of SARS-CoV-2 infection using rapid immunoassays. WHO Interim Guidance. https://www.who.int/publications/i/item/antigen-detection-in-thediagnosis-of-sars-cov-2infection-using-rapid-immunoassays [Online](last visited on 12 November 2020).
TOOLS
Similar articles