Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus

Shin-Hee Kim; In-Ah Jung; Yeon Jin Jeon; Won Kyoung Cho; Kyoung Soon Cho; So Hyun Park; Min Ho Jung; Byoung Kyu Suh

doi:10.6065/apem.2014.19.4.191

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Kim, Jung, Jeon, Cho, Cho, Park, Jung, and Suh: Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus

Original Article

Annals of Pediatric Endocrinology & Metabolism 2014; 19(4): 191-196.

Published online: 31 December 2014

DOI: https://doi.org/10.6065/apem.2014.19.4.191

Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus

Shin-Hee Kim, MD, In-Ah Jung, MD, Yeon Jin Jeon, MD, Won Kyoung Cho, MD, PhD, Kyoung Soon Cho, MD, So Hyun Park, MD, PhD, Min Ho Jung, MD, PhD, Byoung Kyu Suh, MD, PhD

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Address for correspondence: Min Ho Jung, MD, PhD. Department of Pediatrics, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, 10 63(yuksam)-ro, Yeongdeungpo-gu, Seoul 150-713, Korea. Tel: +82-2-3779-1131, Fax: +82-2-783-2589, jmhpe@catholic.ac.kr

Received 15 July 2014 Revised 17 September 2014 Accepted 26 September 2014

(open-access, http://creativecommons.org/licenses/by-nc/3.0/):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

We aimed to investigate serum lipid profiles and glycemic control in adolescents and young adults with type 1diabetes mellitus (T1DM).

Methods

This cross-sectional study included 29 Korean young adults and adolescents with T1DM. The median age was 17 years (range, 10-25 years) and 18 (62.1%) were female. We compared the lipid profiles of patients with dyslipidemia and those without dyslipidemia. Correlations between glycosylated hemoglobin (HbA1c) and lipid profiles (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglyceride [TG]) were determined by linear regression analysis.

Results

Of the 29 patients with T1DM, 11 (37.9%) were classified as having dyslipidemia due to the following lipid abnormality: TC≥200 mg/dL in 8 patients, LDL-C≥130 mg/dL in 4 patients, TG≥150 mg/dL in 2 patients, and HDL-C≤35 mg/dL in 2 patients. Compared to patients without dyslipidemia, patients with dyslipidemia were more likely to have higher values of HbA1c (median, 10.6%; range, 7.5%-12.3% vs. median, 8.0%; range, 6.6%-10.0%; P=0.002) and a higher body mass index z score (median, 0.7; range, -0.57 to 2.6 vs. median, -0.4; range, -2.5 to 2.2; P=0.02). HbA1c levels were positively correlated with TC (P=0.03, R²=0.156) and TG (P=0.005, R²=0.261).

Conclusion

A substantial proportion of adolescents and young adults with T1DM had dyslipidemia. We found a correlation between poor glycemic control and poor lipid profiles in those patients.

Keywords: Diabetes mellitus, Dyslipidemia, Glycemic index, Prevalence, Young adult

Introduction

Hyperglycemia and dyslipidemia are metabolic abnormalities commonly found in young patients with type 1 diabetes mellitus (T1DM), and both increase the risk of cardiovascular disease, the leading cause of mortality in this population1). Many studies have shown that microvascular changes and precursors of atherosclerosis are frequently observed in young patients early in the course of T1DM2,3). Considering that atherosclerosis is a precursor of cerebrovascular disease (CVD) and subacute atherosclerosis exists in young patients with T1DM, young patients with T1DM should be managed as a very high risk group for premature atherosclerosis, especially coronary heart disease3,4).

Furthermore, CVD risk factors in childhood correlate with abnormalities in surrogate markers of atherosclerosis and atherosclerotic lesions in pathology evaluations5,6,7). Several studies have demonstrated serum lipid abnormalities in children with T1DM as well as an association between elevated glycosylated hemoglobin (HbA1c) and serum lipid levels8,9,10,11,12). These studies showed a high prevalence of dyslipidemia and the presence of CVD risk factors in youth with diabetes mellitus, including an association with elevated HbA1c and body mass index (BMI)>90th percentile for age and gender11,13,14).

Limited data are available on the prevalence of dyslipidemia and its association with glycemic control in Korean adolescents and young adults with T1DM. The objective of this study is to assess the lipid profiles and its association with glycemic control in this population.

Materials and methods

1. Subjects

From January 2013 to December 2013, we prospectively enrolled 29 patients who had been diagnosed with T1DM and visited the Department of Pediatrics, Yeouido St. Mary's Hospital. Inclusion criteria included patients with T1DM, age between 11 and 25 years, no other chronic illnesses, and no medications other than insulin. T1DM was defined by clinical parameters, including absolute need for insulin, young age of onset and history of ketosis, and presence of autoantibody15). The median age was 17 years (range, 10-25 years) and 18 patients (62.1%) were female. Median duration of the disease was 7.5 years (range, 0.2-15.6 years). The study was reviewed and approved by the local Institutional Review Board (IRB No. SC13OIS0086) that had jurisdiction over the local study populations, and all participants provided informed consent and/or assent.

2. Data collection and definition

During the study visit, survey information was collected and an examination was performed to measure systolic and diastolic blood pressures, height, weight, and BMI. BMI scores were calculated as weight (kg)/height (m²) and expressed in z scores, according to the standards assessed by the 2007 Korea National Growth Charts16). Samples (blood glucose, HbA1c, total cholesterol [TC], low-density lipoprotein [LDL] cholesterol, high-density lipoprotein [HDL] cholesterol, and triglyceride [TG]) were obtained under conditions of metabolic stability after at least 8 hours of fasting. The mean value of two HbA1c levels measured within 6 months was used as a surrogate marker for recent glycemic control.

Cut points for abnormal lipid levels (TC≥200 mg/dL, LDL cholesterol≥130 mg/dL, HDL cholesterol≤35 mg/dL, and TG≥150 mg/dL) were taken from the Third Report of the National Cholesterol Education Program17) and the American Diabetes Association18). Dyslipidemia was defined by the presence of one or more abnormal serum lipid concentrations. For the present cross-sectional analysis, clinical data, HbA1c, BMI, and lipid profiles were investigated in adolescents and young adults with T1DM. We compared the lipid profiles of patients with dyslipidemia and those without dyslipidemia.

3. Statistical analysis

All statistical analyses were conducted with the use of PASW Statistics ver. 18 (SPSS Inc., Chicago, IL, USA). Nonparametric statistics were applied in the analysis of data with skewed distribution. Continuous variables are expressed as the median with ranges. Differences in the means of continuous variables were tested using the Mann-Whitney U test. Differences in proportions were tested using the Fisher exact test. The Spearman rank correlation test was used to evaluate the correlation between continuous variables. To identify the independent risk factors for dyslipidemia, all variables significant in univariate analysis were included in a multiple logistic regression model. All P-values <0.05 were considered statistically significant.

Results

Table 1 shows the clinical and laboratory variables of T1DM patients with or without dyslipidemia. Median values for fasting lipid measures at the initial visit were as follows: TC, 167 mg/dL (range, 120-256 mg/dL); LDL-C, 94 mg/dL (range, 50-159 mg/dL); HDL-C, 51 mg/dL (range, 28-108 mg/dL); and TG, 82 mg/dL (range, 36-187 mg/dL). Median HbA1c level of the patients was 8.1% (range, 6.6%-13.3%).

Of the 29 patients, 11 (37.9%) were classified as having dyslipidemia due to the following lipid abnormality: TC≥200 mg/dL in 27.6% (8/29 patients), LDL-C≥130 mg/dL in 14.3% (4/28 patients), HDL-C≤35 mg/dL in 7.1% (2/28 patients), and TG≥150 mg/dL in 14.3% (4/28 patients) (Fig. 1).

HbA1c of those patients without dyslipidemia was lower than that of patients with dyslipidemia (median, 8.0%; range, 6.6%-10.0% vs. median, 10.6%; range, 7.5%-12.3%; P=0.002). The BMI z score of T1DM patients without dyslipidemia was lower than that of patients with dyslipidemia (median, -0.4; range, -2.5 to 2.2 vs. median, 0.7; range, -0.57 to 2.6; P=0.02). Although dyslipidemia was more common in females than in males, this finding did not reach the statistical significance (50.0% [9/18 patients] vs. 18.2% [2/11 patients]; P=0.18). There were no differences in age, disease duration, and microvascular complications between the dyslipidemia and no dyslipidemia groups.

The correlation between glycemic control parameters and plasma lipid variables is shown in Fig. 2. A significant positive correlation was found between HbA1c and TC (P=0.03, R²=0.156) and TG (P=0.005, R²=0.261). HbA1c showed no correlation with LDL-C or HDL-C. Multivariate logistic regression analysis indicated that HbA1c was the only independent risk factor for dyslipidemia (adjusted odds ratio, 3.11; 95% confidence interval, 1.35-7.40; P=0.01).

To evaluate the association between lipid values and glycemic control, we categorized patients into two groups using the median value of HbA1c (8.3%) at the time of the study (Table 2). Patients with HbA1c≥8.3% showed a higher incidence of dyslipidemia compared to those with HbA1c<8.3% (64.3% [9/15 patients] vs. 13.3% [2/15 patients]; P=0.008). There were no differences in age, sex, BMI z scores, and disease duration between the two groups.

Discussion

To the best of our knowledge, this study is the first to evaluate the serum lipid profiles and glycemic control in Korean adolescents and young adults with type 1 diabetes. We found that more than one third of Korean adolescents and young adults with T1DM had dyslipidemia, which was significantly associated with a higher HbA1c levels and BMI z scores.

In recent studies, the prevalence of dyslipidemia was shown to be 19.7% of Korean healthy children and adolescents19) and 44.1% in Korean healthy adults20). The overall prevalence of dyslipidemia among adolescents and young adults with T1DM in this study was 37.9%. This prevalence is higher than the 28.6% observed in German and Austrian adolescents and young adults with T1DM21) and comparable to the 39.2% in England children with T1DM10). Therefore, we found high prevalence of dyslipidemia in Korean adolescents and young adults with T1DM. This finding has potential clinical significance, given the well-known relationship between dyslipidemia and cardiovascular events and the fact that lipid levels frequently track from childhood to adulthood22).

Our study showed that HbA1c levels were positively correlated with TC and TG. In a previous study, a positive correlation was found between HbA1c and TC, and TG in children with T1DM10). Maahs et al.23) performed a retrospective analysis of subjects with T1DM by analyzing random lipid levels measured during clinical practice. Their study showed a positive association between HbA1c and both TC and non-HDL-C. Guy et al.13) reported cross sectional data from the SEARCH for Diabetes in Youth (SEARCH) study, in which T1DM subjects with a HbA1c target <7.5% had lower prevalence of dyslipidemia, similar to healthy controls, while T1DM subjects with HbA1c≥7.5% were more likely to have elevated TC and LDL-C levels. A positive correlation between HbA1c and serum lipids has been demonstrated in other cross sectional studies, providing indirect evidence for a beneficial effect of glycemic control on serum lipids in children and young adults11,24). The SEARCH study including 1,193 United States children with T1DM reported lower frequency of lipid abnormalites25) compared to our study and the studies previously described10,21). In the SEARCH study, the incidence of TC≥200 mg/dL, LDL-C≥130 mg/dL, HDL-C≤35 mg/dL and TG≥150 mg/dL was 8.4%, 7.2%, 4.7%, and 2.9%, respectively25). Mean HbA1c of the subjects included in the SEARCH study was 7.7%, which was lower compared to the level of our study (8.9%) and other sudies10,21). This findings support the importance of glycemic control as a determinant of and a potential modifiable risk factor for dyslipidemia.

Our data were equivocal regarding the association between dyslipidemia and BMI z scores. Although in the univariate analysis, BMI z scores were associated with dyslipidemia, this association was lost after controlling for HbA1c in the multivariate logistic regression analysis. The association between being overweight and an adverse lipid profile has been documented in subjects with T1DM21,23,26). In the DCCT (The Diabetes Control and Complications Trial) cohort, excessive weight gain was related to dyslipidemia and declines in HbA1c were associated with improvements in lipid levels only in subjects with the least weight gain during the interventional period27). These observations may be partly explained by the insulin resistance and hyperinsulinemia associated with increased body weight28). In this study, we could not conclude whether or not BMI z scores were independently associated with dyslipidemia because of the small number of cases of dyslipidemia and overweight patients. However, on the basis of the findings from out study and those of previous studies21,23,26,27), maintenance of healthy weight during adolescent and young adult periods may be important to normalize lipid profiles and reduce subsequent risks of CVDs. Further studies including large numbers of patients should be performed to clarify for this issue.

In our study, there was a trend towards a higher prevalence of dyslipidemia in T1DM in females than in males, which is in line with previous data29). Our findings might be partly explained by the different degrees of insulin resistance between the two sexes or a direct effect of hormonal status on enzymes implicated in lipoprotein metabolism21,28).

In addition, increased testosterone levels have been shown to be negatively associated with TC, LDL-C, and HDL-C levels30). In another study, as the testosterone/estradiol ratio decreased, LDL-C, and HDL-C levels increased31).

This study has several limitations. First, repeated measurements of fasting lipids were not made over time in individual subjects. Second, the number of patients included was small compared with the number of risk factors evaluated; thus, compromising the power of both the univariate and the multivariate analyses.

In conclusion, our study is the first report of lipid data in Korean adolescents and young adults with T1DM. We showed a substantial proportion of adolescents and young adults with T1DM had dyslipidemia, and dyslipidemia in this population was associated with poor glycemic control. Given that dyslipidemia is a potentially modifiable CVD risk factor, further studies should be aimed to evaluate the optimal approach for early diagnosis and effective treatment of dyslipidemia among adolescent and young adults with T1DM.

Notes

No potential conflict of interest relevant to this article was reported.

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Fig. 1

Prevalence of dyslipidemia for patients with type 1 diabetes mellitus is shown. TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglyceride.

Fig. 2

Correlation between glycemic control parameters and plasma lipid variables is shown. HbA1c, hemoglobin A1c; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.

Table 1.

Clinical and laboratory variables in type 1 diabetes mellitus patients without and with dyslipidemia

Characteristic	All patients (n=29)	Patients without dyslipidemia (n=18)	Patients with dyslipidemia (n=11)	P-value
Female gender	18 (62.1)	9 (50.0)	9 (81.8)	0.181
Age at visit (yr)	17 (10–25)	16.2 (10–24.2)	17.6 (11–25)	0.383
Age of diabetes diagnosis (yr)	11.4 (3.2–15.9)	11.4 (3.2–14.6)	11.8 (4.8–15.9)	0.672
Duration of disease (yr)	7.5 (0.2–15.6)	7.7 (0.2–15.6)	6.9 (1.5–11.4)	0.673
HbA1c (%)	8.3 (6.6–12.3)	8.0 (6.6–10.0)	10.6 (7.5–12.3)	0.002
Height	163 (134.5-181.5)	160.6 (146.9–180)	164 (134.5–181.5)	0.803
Height, z score	–0.1 (–2.7 to 2.5)	–1.95 (–2.7 to 1.9)	0.5 (–1.2 to 2.5)	0.751
Weight	56.8 (33.5–113)	53.5 (38.5–72)	59 (33.5–113)	0.142
Weight, z score	0.2 (–3.6 to 2.9)	–0.1 (–3.6 to 2.2)	0.7 (–0.1 to 2.9)	0.043
BMI, z score	0.03 (–2.5 to 2.6)	–0.4 (–2.5 to 2.2)	0.7 (–0.57 to 2.6)	0.024
≥1.0	6 (20.7)	2 (11.1)	4 (36.4)	0.164
≥2.0	3 (10.3)	2 (11.1)	1 (9.1)	>0.973
Serum C-peptide	0.1 (0.04–4.0)	0.1 (0.04–3.9)	0.1 (0.04–4.0)	0.802
Lipid profiles
TC (mg/dL)	167 (120–256)	158 (120–189)	213 (154–256)	<0.001
LDL cholesterol (mg/L)^a)	94 (50–159)	78 (50–101)	119 (78–159)	<0.001
HDL cholesterol (mg/dL)^a)	51 (28–108)	48 (38–88)	52 (28–108)	0.813
TG (mg/dL)^a)	82 (36–187)	58 (36–104)	102 (61–187)	<0.001
Microvascular complications
Microalbuminuria	3 (10.3)	2 (11.1)	1 (9.1)	0.542
Retinopathy	0 (0)	0 (0)	0 (0)	NA
Neuropathy	1 (0)	0 (0)	1 (3.3)	NA

Values are presented as number of cases (%) or median (range).

HbA1c, hemoglobin A1c; BMI, body mass index; TC, total cholesterol; LDL cholesterol, low density lipoprotein cholesterol; HDL cholesterol, high density lipoprotein cholesterol; TG, triglyceride; NA, not applicable

^a) These parameters are not available in one patient.

Table 2.

Lipid profiles according to glycemic control in patients with type 1 diabetes mellitus

Variable	HbA1c<8.3% (n=14)	HbA1c≥8.3% (n=15)	P-value
Age (yr)	14.7 (10.8–23)	18.3 (10–25)	0.142
Female gender	9 (64.3)	9 (60)	0.812
BMI, z score	–0.3 (–1.3 to 2.6)	0.19 (–2.5 to 1.9)	0.324
Disease duration (yr)	8.6 (0.2–15.6)	6.9 (1.5–12.7)	0.681
Lipid profiles
TC≥200 mg/dL	1 (7.1)	7/15 (46.7)	0.013
LDL cholesterol ≥130 mg/dL	0 (0)	4/15 (26.7)	0.098
HDL cholesterol≤35 mg/dL	2 (14.3)	1/14 (7.1)	>0.934
TG≥150 mg/dL	0 (0)	4/14 (28.6)	0.098
Dyslipidemia (any of the above abnormalities)	3 (21.4)	8/15 (53.3)	0.008

Values are presented as median (range) or number of cases (%).

HbA1c, hemoglobin A1c; BMI, body mass index; TC, total cholesterol; LDL cholesterol, low-density lipoprotein cholesterol; HDL cholesterol, high-density lipoprotein cholesterol; TG, triglyceride.

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