Serial Short-Term Outcomes of Very-Low-Birth-Weight Infants in the Korean Neonatal Network From 2013 to 2020

Ga Won Jeon; Jang Hoon Lee; Minkyung Oh; Yun Sil Chang

doi:10.3346/jkms.2022.37.e229

Journal List > J Korean Med Sci > v.37(29) > 1516078941

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Jeon, Lee, Oh, and Chang: Serial Short-Term Outcomes of Very-Low-Birth-Weight Infants in the Korean Neonatal Network From 2013 to 2020

Original Article

Pediatrics

Journal of Korean Medical Science 2022; 37(29): e229.

Published online: 12 July 2022

DOI: https://doi.org/10.3346/jkms.2022.37.e229

Serial Short-Term Outcomes of Very-Low-Birth-Weight Infants in the Korean Neonatal Network From 2013 to 2020

Ga Won Jeon^1,^*

, Jang Hoon Lee^2,^*

, Minkyung Oh³

, Yun Sil Chang⁴

¹Department of Pediatrics, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.

²Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea.

³Department of Pharmacology, Inje University College of Medicine, Busan, Korea.

⁴Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Address for Correspondence: Yun Sil Chang, MD, PhD. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea. yschang@skku.edu

Equal contributor:

^*Ga Won Jeon and Jang Hoon Lee contributed equally to this study as co-first authors.

Received 19 May 2022 Accepted 20 June 2022

The Korean Academy of Medical Sciences

https://creativecommons.org/licenses/by-nc/4.0/

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

We aimed to determine the current survival rate and short-term outcomes of very-low-birth-weight infants (VLBWIs) in Korea, as well as whether the survival rate and short-term outcomes have improved over time since 2013, which was when the Korean Neonatal Network (KNN) was launched.

Methods

This study used data from the annual reports of the KNN from 2013 to 2020. A total of 16,351 VLBWIs born at gestational age (GA) ≥ 22 weeks between January 1, 2013, and December 31, 2020, and who were registered in the KNN were enrolled. Serial outcomes were analyzed according to era (2013–14, 2015–16, 2017–18, and 2019–20).

Results

More mothers delivered by cesarean section, had diabetes or hypertension during their pregnancy, and received antenatal steroids when analyzed by era. Fewer infants were intubated at birth and had air leaks when analyzed by era. The overall survival rate of VLBWIs between 2013 and 2020 was 87%. The rate of respiratory distress syndrome was 77% and that of bronchopulmonary dysplasia was 32% between 2013 and 2020. The rates of intraventricular hemorrhage (grade ≥ 3), periventricular leukomalacia, and sepsis decreased over time. The survival rate of infants with a GA of 26 weeks has improved serially according to era.

Conclusion

Since the launch of the KNN in 2013, the survival rates of infants with GA 26 weeks and short-term outcomes have improved, which implies a quality improvement in antenatal and delivery room care. Further studies on the long-term neurodevelopmental outcomes of these KNN registrants are warranted.

Graphical Abstract

Keywords: Infant, Very Low Birth Weight, Infant, Premature, Infant Mortality, Bronchopulmonary Dysplasia, Cerebral Intraventricular Hemorrhage, Leukomalacia, Periventricular

INTRODUCTION

In 2020, the overall birth rate per fertile woman was 0.837 and the number of live births was 272,337 in Korea, the lowest in the world. These values decreased annually to 1.226 and 470,171 in 2010 from 1.760 and 730,678 in 1992, respectively. Further, the rate of high-risk infants born before a gestational age (GA) of 37 weeks (preterm infants), born with birth weight of < 2.5 kg (low-birth-weight infants [LBWIs]), and born with birth weight of < 1.5 kg (very-low-birth-weight infants [VLBWIs]) has increased from 5.8%, 4.9%, and 0.5% in 2010 to 8.5%, 6.8%, and 0.8% in 2020, respectively.1

Recent advances in perinatal care for mothers in preterm labor and neonatal respiratory care, such as the introduction of pulmonary surfactants for preterm infants,2 improved the survival rates of VLBWIs. In the United States, the survival rates improved markedly in infants with a GA of 23–24 weeks; in addition, survival without major morbidities except bronchopulmonary dysplasia (BPD) improved in infants with a GA of 25–28 weeks.3 Similar results were reported using the database registered to the Korean Neonatal Network (KNN). These showed improved survival rates in preterm infants with a GA of 23–24 weeks, which was accompanied by improved survival without major morbidities, including BPD, in preterm infants with a GA of 25–26 weeks. This improved survival was due to the use of antenatal corticosteroids and improved Apgar scores at 5 minutes.4

VLBWIs still have higher risks of mortality and morbidities than term newborns, despite advanced perinatal and neonatal care that results in improved survival rates without major morbidities. This remains a large burden and challenge for societies and health systems with greater amounts of VLBWIs as well as seriously decreased birth rates.5 Between 2013 and 2016, the overall survival rate of VLBWIs was 86%, which was much lower in VLBWIs with a GA of < 28 weeks than in those with a GA of ≥ 28 weeks.6 In this period, survival rates did not improve. In addition, the rate of BPD was much higher in VLBWIs with a GA of < 28 weeks than in those with a GA of ≥ 28 weeks, which improved in 2016 compared with in 2013.6

The KNN is a prospective nationwide large cohort registry. It contains the data of VLBWIs from 70 participating neonatal intensive care units (NICUs), covering > 80% of VLBWIs in Korea since the KNN was launched in 2013.7 A total of 1,826 VLBWIs were registered among 2,100 VLBWIs born in Korea in 2020, accounting for 87% (1,826/2,100) of VLBWIs born in Korea in 2020.1 8 The KNN plays a pivotal role in improving the quality of neonatal care provided at participating NICUs, ultimately improving the health of high-risk infants in Korea with the lowest birth rates in the world by providing annual reports with survival rates and major morbidities and by implementing the quality improvement project.9 Approximately 10 years have passed since the KNN was launched in 2013. Therefore, we aimed to determine the current survival rates and major morbidities of VLBWIs in Korea, as well as whether these have improved over time from 2013 to 2020.

METHODS

Data collection

This study used the data from the annual reports of the KNN from 2013 to 2020.8 10 11 12 13 14 15 16 A total of 16,351 VLBWIs born at a GA of ≥ 22 weeks between January 1, 2013, and December 31, 2020, and who registered in the KNN were enrolled. The number of enrolled VLBWIs was 1,396, 2,123, 2,390, 2,358, 2,135, 2,125, 1,999, and 1,825 from 2013 to 2020, respectively. The definition of each disease was based on the manual of operations of the KNN. The definitions are as follows. BPD was assessed at 36 weeks’ postmenstrual age, with patients requiring oxygen with FiO₂ > 0.21 or positive pressure ventilation,17 which is equivalent to moderate-to-severe BPD according to the 2001 definition by the National Institute of Child Health and Human Development (NICHD). Patent ductus arteriosus (PDA, requiring surgery), necrotizing enterocolitis (NEC, stage ≥ 2),18 retinopathy of prematurity (ROP, requiring therapy),19 intraventricular hemorrhage (IVH, grade ≥ 3),20 periventricular leukomalacia (PVL), and culture-proven sepsis were also evaluated. The incidence of PDA requiring surgery was assessed in infants with symptomatic PDA. The rate of ROP requiring therapy was also assessed among infants with ROP, but not among all infants with a specific GA. Mortality in the NICU was defined as death during NICU admission.

Statistical analysis

Categorical variables are presented as percentages (range of probability; 95% confidence interval) and continuous variables as mean ± pooled standard deviation. Categorical variables were compared using the χ² test or Fisher’s exact test, and continuous variables were compared using the t-test or Mann-Whitney U test, as appropriate. The Cochran-Armitage test was conducted for trend analysis.

Subgroup analysis for major morbidities was performed according to GA (22–25, 26–27, 28–31, and ≥ 32 weeks) and era (2013–14, 2015–16, 2017–18, and 2019–20). Furthermore, subgroup analysis for survival rates was performed according to GA and era (2013–14, 2015–16, 2017–18, and 2019–20). Statistical significance was set at a P value of < 0.05. Statistical analyses were conducted using R software (version 3.6.3; The R Foundation for Statistical Computing Vienna, Austria).

Ethics statement

The Institutional Review Board of each participating hospital including the Inha University Hospital (IRB No. 2016-03-006) reviewed and approved the use of the KNN registry during admission to the NICU and follow-up at a corrected age of 18–24 months and 3 years. The KNN Ethics Committee reviewed and approved this study. All methods were performed in accordance with the approved protocol. Written informed consent was obtained from the parents of the infants at enrollment.

RESULTS

Maternal and neonatal characteristics

Among the enrolled VLBWIs born in Korea between 2013 and 2020, 37% were born from multiple births and 79% were born via cesarean section (Table 1). The rates of maternal diabetes and hypertension during pregnancy were 10% and 22%, respectively. The rates of maternal chorioamnionitis and premature rupture of membrane were 29% and 35%.

Table 1

Maternal and neonatal characteristics

Characteristics			Total	2013–14	2015–16	2017–18	2019–20	P
Maternal characteristics
	No. of births
		Singleton	10,341 (63.1)	65 (63–66)	64 (62–65)	64 (63–66)	65 (63–66)	0.032
		Twin	5,347 (32.6)	32 (31–34)	32 (30–33)	31 (30–33)	32 (31–34)	0.046
		≥ Triplet	702 (4.3)	3 (2–4)	5 (4–5)	4 (4–5)	3 (2–4)	< 0.001
	Method of pregnancy
		Natural	12,169 (74.2)	79 (77–80)	76 (75–77)	75 (74–76)	79 (77–80)	< 0.001
		Assisted reproductive technology	4,221 (25.8)	21 (20–23)	24 (23–25)	25 (24–26)	21 (20–23)	< 0.001
	Cesarean section		13,010 (79.4)	74 (73–76)	79 (78–80)	81 (80–82)	82 (81–84)	0.004
	Maternal diabetes during pregnancy		1,665 (10.2)	8 (7–9)	9 (8–10)	11 (10–12)	13 (12–14)	< 0.001
	Maternal hypertension during pregnancy		3,604 (22.0)	20 (19–21)	21 (20–22)	23 (22–24)	24 (23–26)	< 0.001
	Histologic chorioamnionitis		4,722 (28.8)	28 (26–29)	29 (28–31)	30 (29–31)	28 (27–29)	0.911
	Premature rupture of membrane		5,703 (34.8)	36 (34–37)	35 (34–36)	33 (32–35)	35 (34–37)	0.507
	Antenatal steroid therapy		13,271 (81.0)	74 (72–75)	78 (77–80)	84 (83–85)	87 (86–88)	< 0.001
Neonatal characteristics
	Initial resuscitation		14,607 (89.7)	89 (88–90)	89 (88–90)	91 (90–92)	90 (89–91)	0.545
		Intubation	9,742 (66.7)	75 (74–77)	70 (69–72)	62 (61–64)	59 (58–61)	< 0.001
		Cardiac compression	729 (5.0)	5 (5–6)	6 (5–6)	5 (4–6)	4 (3–4)	0.005
	Respiratory distress syndrome		12,620 (77.0)	79 (77–80)	78 (77–79)	77 (76–78)	74 (73–76)	0.116
	Air leak		876 (5.3)	6 (5–7)	5 (5–6)	6 (5–6)	4 (4–5)	0.003
	Pulmonary hemorrhage		979 (6.0)	7 (6–8)	6 (5–7)	6 (5–6)	5 (4–6)	< 0.001
	Postnatal steroid therapy		3,791 (23.1)	24 (22–25)	21 (20–23)	24 (23–25)	24 (22–25)	0.302

Values are expressed as number (%) or percentage (range of probability; 95% confidence interval).

More mothers of KNN registrants delivered by cesarean section when analyzed according to era (74%, 79%, 81%, and 82% in 2013–14, 2015–16, 2017–18, and 2019–20, respectively) (Table 1). The rates of maternal diabetes and hypertension during pregnancy also increased according to era. A total of 81% of mothers of KNN registrants received antenatal steroids. The rate of antenatal steroid therapy increased according to era (74%, 78%, 84%, and 87% in 2013–14, 2015–16, 2017–18, and 2019–20, respectively).

A total of 90% of VLBWIs required resuscitation at birth. For advanced resuscitation, 67% and 5% of VLBWIs required intubation and cardiac compression at birth, respectively (Table 1). The rates of intubation and cardiac compression at birth were decreased according to era. Fewer infants had air leaks when analyzed according to era (6% in 2013–14 vs. 4% in 2019–20).

Short-term outcomes according to GA

Among the 16,351 enrolled infants between 2013 and 2020, the survival rate was the lowest at 33% in infants with a GA of 22–23 weeks, which increased to 64% in infants with a GA of 24–25 weeks, increased to 85% in infants with a GA of 26–27 weeks, and was over 90% in more mature infants with a GA of ≥ 28 weeks (Table 2).

Table 2

Short-term outcomes according to gestational age

Short-term outcomes	Total (N = 16,351)	Gestational age, wk
Short-term outcomes	Total (N = 16,351)	22–23 (n = 758)	24–25 (n = 2,234)	26–27 (n = 3,204)	28–29 (n = 4,339)	30–31 (n = 3,196)	≥ 32 (n = 2,620)
Survival rate	87 (86–87)	33 (30–36)	64 (62–66)	85 (84–86)	94 (94–95)	97 (96–97)	98 (97–98)
Apgar score at 1 min	4.8 ± 1.8	2.5 ± 1.5	3.3 ± 1.7	3.7 ± 1.7	4.8 ± 1.9	5.5 ± 1.8	6.2 ± 1.8
Apgar score at 5 min	6.9 ± 1.6	4.7 ± 2.1	5.6 ± 1.9	6.0 ± 1.7	7.0 ± 1.6	7.5 ± 1.4	8.1 ± 1.3
BT, °C	36.1 ± 0.6	35.5 ± 1.0	36.0 ± 0.7	36.1 ± 0.6	36.3 ± 0.6	36.3 ± 0.5	36.2 ± 0.5
RDS	77 (76–78)	98 (97–99)	98 (98–99)	96 (95–97)	89 (88–90)	63 (62–65)	26 (24–27)
BPD	32 (31–32)	87 (83–91)	72 (69–74)	50 (48–52)	28 (27–29)	17 (16–19)	7 (6–8)
PDA (requiring surgery)	32 (31–34)	44 (39–50)	46 (43–49)	38 (35–40)	23 (21–25)	18 (15–21)	20 (15–25)
NEC (stage ≥ 2)	7 (6–7)	16 (13–18)	15 (14–17)	9 (8–10)	5 (4–5)	3 (2–3)	1 (1–2)
ROP (requiring therapy)	27 (26–28)	61 (55–67)	43 (40–46)	25 (23–27)	13 (11–15)	5 (3–8)	3 (0–6)
IVH (grade ≥ 3)	9 (9–10)	42 (38–46)	26 (24–28)	11 (10–12)	5 (4–6)	2 (2–3)	1 (0–1)
PVL	8 (7–8)	15 (12–18)	13 (12–15)	10 (9–11)	8 (7–9)	5 (5–6)	2 (2–3)
Sepsis	20 (19–20)	38 (35–42)	38 (36–40)	29 (28–31)	17 (16–18)	10 (9–11)	6 (5–7)
Hospital stay, days	58.1 ± 38.6	51.0 ± 68.9	87.6 ± 61.5	90.4 ± 42.1	67.1 ± 27.7	52.4 ± 23.6	39.3 ± 23.9

Values are expressed as mean ± pooled standard deviation or percentage (range of probability; 95% confidence interval).

BT = body temperature at admission, RDS = respiratory distress syndrome, BPD = bronchopulmonary dysplasia, PDA = patent ductus arteriosus, NEC = necrotizing enterocolitis, ROP = retinopathy of prematurity, IVH = intraventricular hemorrhage, PVL = periventricular leukomalacia.

The incidence of respiratory distress syndrome (RDS) and BPD was 77% and 32%, respectively (Table 2). Over 90% of infants with a GA of < 28 weeks had RDS. The rate of RDS decreased abruptly in infants with a GA of ≥ 30 weeks (63% and 26% in infants with a GA of 30–31 and ≥ 32 weeks, respectively). A total of 87% of infants with a GA of 22–23 and 72% of infants with a GA of 24–25 weeks had BPD. The rate of BPD decreased abruptly in more mature infants with a GA of ≥ 28 weeks. Apgar scores at 1 and 5 minutes and body temperatures at admission increased with advancing GA. The rates of PDA (requiring surgery), NEC (stage ≥ 2), ROP (requiring therapy), IVH (grade ≥ 3), PVL, and sepsis also decreased with advancing GA (Table 2).

Short-term outcomes according to era

The overall survival rate of the enrolled VLBWIs was 87% between 2013 and 2020. The overall survival rate did not significantly change from 87% in 2013–14 to 88% in 2019–20 (Table 3). The incidence of BPD decreased to 29% in 2015–16 compared with that in 2013–14, which had increased to 33% from 2017. In addition, fewer PDAs were surgically ligated, 35% in 2013–14 and 31% in 2019–20, a difference that was not statistically significant.

Table 3

Short-term outcomes according to era

Short-term outcomes	2013–14 (n = 3,519)	2015–16 (n = 4,748)	2017–18 (n = 4,260)	2019–20 (n = 3,824)	P
Survival rate	87 (86–88)	86 (85–87)	86 (85–87)	88 (87–89)	0.771
BPD	31 (30–33)	29 (27–30)	33 (32–35)	33 (32–35)	0.019
PDA (requiring surgery)	35 (32–37)	31 (28–33)	33 (31–36)	31 (29–34)	0.364
NEC (stage ≥ 2)	7 (6–8)	7 (6–7)	7 (6–8)	6 (5–7)	0.481
ROP (requiring therapy)	28 (26–31)	27 (25–29)	27 (24–29)	27 (24–29)	0.471
IVH (grade ≥ 3)	11 (9–12)	9 (8–10)	9 (8–10)	8 (7–9)	0.003
PVL	9 (8–10)	7 (6–8)	8 (7–9)	7 (6–8)	0.042
Sepsis	21 (20–23)	21 (20–22)	20 (19–21)	17 (15–18)	< 0.001

Values are expressed as percentage (range of probability; 95% confidence interval).

BPD = bronchopulmonary dysplasia, PDA = patent ductus arteriosus, NEC = necrotizing enterocolitis, ROP = retinopathy of prematurity, IVH = intraventricular hemorrhage, PVL = periventricular leukomalacia.

The rates of IVH (grade ≥ 3) and PVL had a tendency to decrease serially according to era (11% and 9% in 2013–14 vs. 8% and 7% in 2019–20), with statistical significance (Table 3). Furthermore, sepsis decreased significantly from 21% in 2013–14 to 17% in 2019–20.

Trend analysis of survival rates according to GA from 2013 to 2020

The survival rate was the lowest in infants with a GA of 22 weeks, which improved with advancing GA (Table 4). The survival rate of infants with a GA of 26 weeks improved dramatically according to era (79% in 2013–14 vs. 88% in 2019–20), with statistical significance. The survival rate of infants with a GA of 23 and 25–26 weeks in 2019–20 was higher than that in 2017–18.

Table 4

Trend analysis of survival rates according to gestational age from 2013 to 2020

Gestational age, wk	2013–14 (n = 3,519)	2015–16 (n = 4,748)	2017–18 (n = 4,260)	2019–20 (n = 3,824)	P
22	17 (4–29)	11 (3–20)	17 (6–28)	15 (2–29)	0.883
23	42 (34–51)	37 (29–44)	35 (27–42)	39 (31–47)	0.559
24	62 (55–69)	51 (46–57)	56 (50–62)	56 (50–62)	0.477
25	77 (72–82)	66 (61–71)	64 (58–70)	75 (70–80)	0.583
26	79 (75–84)	79 (75–82)	82 (78–86)	88 (85–92)	< 0.001
27	89 (86–93)	87 (84–90)	88 (85–91)	87 (84–90)	0.460
28	93 (91–96)	93 (91–95)	93 (91–95)	95 (93–97)	0.346
29	95 (93–97)	95 (94–97)	95 (93–97)	96 (94–98)	0.701
30	94 (92–96)	98 (97–99)	96 (94–98)	97 (95–99)	0.190
31	97 (95–99)	97 (95–98)	97 (95–99)	98 (97–100)	0.231
≥ 32	99 (97–100)	98 (97–99)	99 (99–100)	98 (97–99)	0.727

Values are expressed as percentage (range of probability; 95% confidence interval).

Trend analyses of major morbidities according to GA from 2013 to 2020

In infants with a GA of 22–25 weeks, the incidence of BPD tended to decrease from 2013–14 to 2019–20 with statistical significance (Table 5). The incidence of BPD did not decrease in infants with a GA of ≥ 26 weeks. The rate of IVH (grade ≥ 3) in infants with a GA of 22–25 weeks decreased serially without statistical significance (32%, 30%, 29%, and 27% in 2013–14, 2015–16, 2017–18, and 2019–20, respectively). In infants with a GA of 26–27 weeks, the rates of IVH (grade ≥ 3) and PVL decreased significantly according to era (IVH, 15% in 2013–14 vs. 10% in 2019–20, P = 0.041; PVL, 14% in 2013–14 vs. 9% in 2019–20, P = 0.026). The rate of sepsis decreased in infants with a GA of 26–27 weeks without statistical significance (32%, 30%, 29%, and 26% in 2013–14, 2015–16, 2017–18, and 2019–20). In infants with a GA of 28–31 weeks, the rates of sepsis decreased significantly according to era (16% in 2013–14 and 11% in 2019–20).

Table 5

Trend analyses of major morbidities according to gestational age from 2013 to 2020

Major morbidities		2013–14 (n = 3,519)	2015–16 (n = 4,748)	2017–18 (n = 4,260)	2019–20 (n = 3,824)	P
BPD		31 (30–33)	29 (27–30)	33 (32–35)	33 (32–35)	0.019
	22–25	50 (45–54)	51 (47–56)	34 (29–38)	40 (35–45)	0.006
	26–27	62 (58–66)	66 (63–69)	58 (54–61)	55 (51–59)	0.078
	28–31	32 (29–34)	35 (33–37)	36 (34–38)	35 (33–38)	0.135
	≥ 32	8 (6–10)	6 (4–8)	7 (5–9)	7 (5–9)	0.757
PDA (requiring surgery)		35 (32–37)	31 (28–33)	33 (31–36)	31 (29–34)	0.364
	22–25	48 (43–53)	42 (37–47)	48 (42–53)	44 (39–50)	0.770
	26–27	40 (35–45)	37 (33–42)	40 (35–45)	34 (29–39)	0.378
	28–31	22 (19–26)	21 (17–24)	21 (18–25)	21 (17–24)	0.675
	≥ 32	18 (10–27)	17 (9–25)	20 (10–30)	27 (16–38)	0.278
NEC (stage ≥ 2)		7 (6–8)	7 (6–7)	7 (6–8)	6 (5–7)	0.481
	22–25	15 (13–18)	15 (13–17)	17 (14–19)	14 (12–17)	0.837
	26–27	9 (7–12)	9 (7–11)	11 (9–13)	8 (6–9)	0.504
	28–31	4 (3–4)	4 (3–5)	4 (3–5)	4 (3–5)	0.648
	≥ 32	2 (1–3)	2 (1–3)	1 (1–2)	1 (0–2)	> 0.999
ROP (requiring therapy)		28 (26–31)	27 (25–29)	27 (24–29)	27 (24–29)	0.471
	22–25	47 (42–53)	47 (42–52)	47 (42–52)	42 (37–47)	0.431
	26–27	22 (17–26)	24 (20–28)	26 (22–30)	27 (23–31)	0.174
	28–31	13 (9–17)	10 (7–13)	11 (8–14)	11 (8–15)	0.634
	≥ 32	14 (0–28)	0 (0–0)	3 (0–8)	0 (0–0)	0.033
IVH (grade ≥ 3)		11 (9–12)	9 (8–10)	9 (8–10)	8 (7–9)	0.003
	22–25	32 (28–36)	30 (27–33)	29 (25–32)	27 (23–30)	0.114
	26–27	15 (12–17)	10 (8–12)	11 (9–13)	10 (8–12)	0.041
	28–31	4 (3–5)	4 (3–5)	4 (3–5)	3 (2–4)	0.518
	≥ 32	1 (0–1)	1 (0–2)	1 (0–2)	0 (0–1)	0.522
PVL		9 (8–10)	7 (6–8)	8 (7–9)	7 (6–8)	0.042
	22–25	15 (12–18)	11 (9–13)	15 (12–18)	14 (11–16)	0.883
	26–27	14 (11–16)	8 (7–10)	10 (8–12)	9 (7–11)	0.026
	28–31	7 (6–9)	7 (6–8)	7 (6–8)	6 (5–7)	0.282
	≥ 32	3 (2–4)	1 (1–2)	2 (1–3)	2 (1–3)	0.451
Sepsis		21 (20–23)	21 (20–22)	20 (19–21)	17 (15–18)	< 0.001
	22–25	37 (33–41)	44 (40–47)	39 (35–42)	32 (28–35)	0.087
	26–27	32 (28–35)	30 (27–33)	29 (26–32)	26 (23–29)	0.058
	28–31	16 (14–17)	15 (13–16)	15 (13–16)	11 (9–12)	< 0.001
	≥ 32	6 (4–8)	6 (4–7)	7 (5–8)	5 (3–6)	0.481

Values are expressed as percentage (range of probability; 95% confidence interval).

DISCUSSION

We believe that this study makes a significant contribution to the literature because, to the best of our knowledge, it is the first to evaluate the overall survival rate and major morbidities of VLBWIs in Korea born between 2013 and 2020 using a prospective nationwide large cohort registry. More mothers delivered by cesarean section, had diabetes or hypertension during their pregnancy, and received antenatal steroids when analyzed according to era. Fewer infants were intubated at birth and had air leaks when analyzed according to era. The overall survival rate of VLBWIs between 2013 and 2020 was 87% in the present study. The rates of RDS and BPD were 77% and 32%. The rates of ligation of PDA among infants with PDA, NEC (stage ≥ 2), ROP requiring therapy among infants with ROP, and IVH (grade ≥ 3) were 32%, 7%, 27%, and 9%, respectively.

A total of 79% of VLBWIs were born by cesarean section between 2013 and 2020, which increased from 74% in 2013–14 to 82% in 2019–20. Delivery by cesarean section was performed in 62%, 81%, and 78% of infants with a GA of < 24, 24–25, and 26–27 weeks, respectively, according to the data from the annual reports of the KNN. These rates were higher than those reported in the Australian and New Zealand Neonatal Network (ANZNN) report (44.8%, 56.4%, and 69.3% in infants with a GA of < 24, 24–25, and 26–27 weeks, respectively21).

Exposure to antenatal steroids is associated with decreased mortality22 and fewer morbidities23 in preterm infants, especially in infants with a low GA.24 A higher number of mothers of KNN registrants received antenatal steroids, which increased from 74% in 2013–14 to 87% in 2019–20. However, the rate of antenatal steroid therapy is still low compared with that in the Canadian Neonatal Network (CNN) or ANZNN reports. The rate of antenatal steroid administration was only 43% in infants with a GA of 22 weeks, and this increased to 79% and 83% in infants with a GA of 23 and 24 weeks, respectively, in the present study in 2020.8 The rate of antenatal steroid administration was 87% in infants with a GA of 22–28 weeks and 92% in infants with a GA of 29–32 weeks in the present study in 2020. More than 90% of mothers of CNN registrants with a GA of < 33 weeks received antenatal steroids in 2020.25 Only 4.5% and 5.8% of mothers of CNN registrants with a GA of 22–28 and 29–32 weeks, respectively, did not receive antenatal steroids in 2020. In addition, antenatal steroid therapy was performed in 92% of infants with a GA of < 32 weeks according to the ANZNN report,21 a rate higher than that in the present study.

Apgar scores at 1 minute were 3, 3, and 4, which at 5 minutes were 5, 6, and 6 in the present study in infants with a GA of < 24, 24–25, and 26–27 weeks between 2013 and 2020, respectively. Apgar scores at 1 and 5 minutes according to the annual report of the KNN in 2020 were 3, 3, 4 and 5, 6, and 7 in infants with a GA of < 24, 24–25, and 26–27 weeks, values that were still lower than those reported in the ANZNN report (Apgar scores at 1 minute: 3, 5, and 5, Apgar scores at 5 minutes: 6, 7, and 8 in infants with a GA of < 24, 24–25, and 26–27 weeks, respectively21).

Body temperature at admission was between 36.0°C and 36.3°C in infants with a GA of ≥ 24 weeks; however, it was 35.5°C in infants with a GA of < 24 weeks in the present study between 2013 and 2020. Body temperature at admission increased to 35.9°C and 36.1°C in infants with a GA of < 24 and 24–25 weeks according to the annual report of the KNN in 2020; however, this was lower than the values reported in the ANZNN report (between 36.3°C and 36.7°C21).

The survival rate of VLBWIs was 86% between 2013 and 2016 according to the study by Lee et al.,6 which improved to 88% between 2019 and 2000 and finally to 89% in 2020 in the present study. The survival rates in 2020 in the present study were 29%, 44%, 60%, and 82% in infants with a GA of 22, 23, 24, and 25 weeks, respectively.8 In the CNN report,25 the survival rates in 2020 were 27%, 49%, 73%, and 85% in infants with a GA of 22, 23, 24, and 25 weeks, respectively. In the ANZNN report,21 the survival rates in 2019 were 63%, 70%, and 83% in infants with a GA of < 24, 24, and 25 weeks. The survival rates of infants with a GA of 22–23 weeks in the present study are comparable to those in the CNN report, which were considerably lower than those reported in the ANZNN report. The survival rate of infants with a GA of 24 weeks was still lower than the values reported in the CNN and ANZNN reports (60% in the KNN, 73% in the CNN report, and 70% in the ANZNN report). The survival rate of infants with a GA of 25 weeks was comparable to those in the CNN and ANZNN reports (82% for the KNN, 85% for the CNN, and 83% for the ANZNN report). Finally, infants with a GA of 26 weeks in the present study in 2020 attained a survival rate of > 90%, which is comparable to the values reported in the CNN and ANZNN reports. Infants with a GA of 27 weeks within the CNN report and GA of 26 weeks within the ANZNN report attained survival rates of > 90%.

Although not statistically significant, the overall survival rate of preterm infants born in 2020 improved compared with that in the previous era. Furthermore, the survival of infants with a GA of 26 weeks markedly improved from 79% in 2013–14, 88% in 2019–20, and finally 91% in 2020. These findings should be highlighted. Improved survival in extremely preterm infants has been shown to be associated with improved survival without major morbidities in more mature preterm infants.3 4 Therefore, we can expect improved intact survival without major morbidities in more mature preterm infants in the KNN in the near future.

BPD is one of the most serious complications of preterm infants, causing long-term adverse outcomes on respiratory, neurodevelopmental, and growth outcomes.26 The rates of BPD in the present study in 2020 were 77%, 88%, and 69% in infants with a GA of < 24, 24, and 25 weeks, which is comparable to the values reported in the CNN and ANZNN reports (82%, 83%, 76% in the CNN report;25 92%, 81%, 72% in the ANZNN report21 in infants with a GA of < 24, 24, and 25 weeks, respectively). In particular, fewer infants with a GA of < 24 and 25 weeks had BPD than the CNN or ANZNN registrants. However, higher mortality rate among infants with smaller GA may be related to fewer rate of morbidities among survivors.27 Further, KNN uses NICHD 2001 definition of BPD. This definition cannot diagnose preterm infants as having BPD who die of respiratory failure before 36 weeks’ postmenstrual age, the most severe form of BPD. The rate of BPD decreased to 59% and 45% in infants with a GA of 26 and 27 weeks, and this rate finally decreased to 40% in infants with a GA of 28 weeks in the annual report of the KNN in 2020. The rates of BPD in infants with a GA of 26, 27, and 28 weeks were 56%, 42%, and 37% according to the CNN report, and these were 60%, 54%, and 40% according to the ANZNN report. The incidence of BPD has not decreased or even increased despite remarkable advances in perinatal and neonatal care.3 28 The improved survival of extremely preterm infants with a high risk of BPD is one of the reasons for this. In accordance with this trend, the incidence of BPD did not decrease in the present study (31% in 2013–14, 29% in 2015–16, and 33% both in 2017–18 and 2019–20).

Surgical interventions during NICU admission were associated with an increased risk of long-term neurodevelopmental impairment.29 Ligation of the PDA is one of the most commonly performed operations in the NICU. Therefore, PDA ligation rate can be an important risk factor for long-term neurodevelopmental impairment in preterm infants, though there are still controversies whether surgical ligation or medical treatment is better for symptomatic PDA of preterm infants.30 31 Overall, 24%, 23%, and 6% of PDAs among all infants with a specific GA of < 25, 25–26, and 27–28 weeks were surgically ligated in the present study in 2020. The rate of PDA ligation was modified for comparison with those in other studies. In the original version of the annual report of the KNN, the rate of ligation of PDA was assessed among symptomatic PDA cases, not among all PDA cases or among all patients. A total 11.4%, 6.9%, and 2.7% of PDAs among total infants with a GA of < 25, 25–26, and 27–28 weeks were ligated according to the CNN report.25 More infants among KNN registrants received PDA ligation than those among CNN registrants.

The rates of NEC (stage ≥ 2) were 19%, 11%, and 6% in infants with a GA of < 25, 25–26, and 27–28 weeks in the present study by the annual report of the KNN in 2020, which were higher than those in the CNN report (13%, 7%, and 3% in infants with a GA of < 25, 25–26, and 27–28 weeks, respectively25). Furthermore, the rate of NEC (stage ≥ 2) in infants with a GA of < 28 weeks was 12% in the present study, which was also higher than that in the ANZNN report (7% in infants with a GA of < 28 weeks21).

The rates of ROP requiring therapy were 21%, 23%, 24%, 23%, and 4% among all infants with a specific GA of < 24, 24, 25, 26, and 27–28 weeks, respectively, in the present study in 2020. This rate was modified for comparison with other studies. In the original version of the annual report of the KNN, the rate of ROP requiring therapy was assessed among infants with ROP, not among all infants with a specific GA. The rates of ROP (stage ≥ 3) were 48%, 35%, 21%, 14%, and 4% in all infants with a GA of < 24, 24, 25, 26, and 27–28 weeks, respectively, according to the ANZNN report.21 In addition, the rates of severe ROP (stage ≥ 3 and/or requiring laser or intraocular injection) were 58%, 36%, 26%, 12%, and 5% in all infants with a GA of < 24, 24, 25, 26, and 27 weeks, respectively, according to the CNN report.25

The rates of IVH (grade ≥ 3) and PVL decreased significantly according to era and advancing GA. This finding is encouraging because IVH and PVL are closely related to the long-term neurodevelopmental impairment of preterm infants and to cerebral palsy.32 IVH (grade ≥ 3) occurred in 39%, 26%, 17%, 10%, and 8% of infants with a GA of < 24, 24, 25, 26, and 27 weeks, respectively in the annual report of the KNN in 2020. The rates of PVL were 13%, 13%, 11%, 9%, and 9% in infants with a GA of < 24, 24, 25, 26, and 27 weeks, respectively. Fewer instances of IVH (grade ≥ 3) occurred in infants with a GA of < 24, 24, 25, 26, and 27 weeks, with rates of 27%, 18%, 14%, 7%, and 3%, respectively according to the ANZNN report. In addition, the overall rate of PVL was 1–3% in infants with a GA of 25–31 weeks according to the ANZNN report.21 IVH (grade ≥ 3) and/or PVL occurred in 30%, 26%, 17%, 10%, and 9% of infants with a GA of < 24, 24, 25, 26, and 27 weeks, respectively, according to the CNN report.25

Sepsis is one of the major causes of mortality and morbidity in very-preterm infants.33 The rate of sepsis has been decreased serially from 21% in 2013–14 to 17% in 2019–20, and finally to 16% in 2020, which represents improved neonatal care and infection control. Sepsis occurred in 31%, 28%, and 18% of infants with a GA of < 25, 25–26, and 27–28 weeks, respectively, in the present study in 2020. Sepsis was less prevalent in infants with a GA of < 25 weeks in the present study compared with that in the CNN report (31% in the present study vs. 39% in the CNN report25). However, sepsis was more frequent in infants with a GA of ≥ 25 weeks than in the CNN report (28% and 18% in the present study vs. 22% and 10% among CNN infants with a GA of 25–26 and 27–28 weeks).

Increased Apgar score and body temperature at admission and decreased need for advanced resuscitation at birth, such as intubation and cardiac compression, imply improved quality in delivery room care. Furthermore, the increased rate of antenatal steroid therapy implies a quality improvement in antenatal care. Improved antenatal and delivery room care can result in decreased IVH (grade ≥ 3) and PVL, further improving long-term neurodevelopmental outcomes.

The present study has some limitations. First, as we used data from the annual report of the KNN based on the its pre-set registry data, we could not analyze all of the data in detail by GA or era. Further, in the annual report of the KNN, hospital stay was based on total registrants not survivors, therefore infants with higher morality such as 22–23 weeks presenting shorter hospital stay among survivors was inevitable. Second, in comparison with the CNN or ANZNN reports, methodological differences in statistics were inevitable. For example, the CNN and ANZNN reports assessed the incidence of ROP requiring therapy among the total number of infants with specific GAs, while this was assessed among infants with ROP by the KNN. Furthermore, the data collection methods differed among studies. Therefore, the disease categories and incidences were different. For ROP cases requiring therapy, cases of ROP (stage ≥ 3) were collected by the ANZNN, and severe ROP cases (stage ≥ 3 and/or requiring laser or intraocular injection) were collected by the CNN. Therefore, a direct comparison between international networks was impossible. The strength of this study is that it is the first to analyze the overall survival rates and major morbidities of VLBWIs in Korea born between 2013 and 2020 using a prospective nationwide large cohort registry. This study also analyzed trends in survival rates and major morbidities according to era and GA.

In conclusion, since the launch of the KNN in 2013, the survival rate of infants with GA 26 weeks has improved serially; these findings are encouraging. We have already found that improved survival was accompanied by improved intact survival without major morbidities in more mature preterm infants; therefore, we can expect improved survival without major morbidities in the near future. Furthermore, the incidence of IVH, PVL, and sepsis has decreased serially. The decreased incidence of IVH and PVL may be related to improved long-term neurodevelopmental outcomes. Further studies on the long-term neurodevelopmental outcomes of these KNN registrants are warranted. We can also expect decreased mortality and morbidities in very-preterm infants, along with decreased incidence of sepsis. Furthermore, the rates of intubation at birth, and air leaks decreased over time implying improved delivery room care. Further studies regarding the effect of the changes of maternal and neonatal basal characteristics according to the changes of perinatal care and NICU care to short-term outcomes of these infants are warranted. Also, further studies analyzing whether there are changes of long-term outcomes in accordance with the changes of short-term outcomes are needed.

Notes

Funding: This work was funded by the Korea National Institute of Health (2022-ER0603-00#).

Disclosure: The authors have no potential conflicts of interest to disclose.

Author Contributions:

Conceptualization: Jeon GW, Lee JH, Chang YS.
Data curation: Oh M.
Formal analysis: Oh M.
Methodology: Jeon GW, Lee JH, Oh M, Chang YS.
Writing - original draft: Jeon GW.
Writing - review & editing: Lee JH, Oh M, Chang YS.

References

1. Statistics Korea. Birth Statistics in 2020. Daejeon, Korea: Statistics Korea;2021.

2. Jeon GW. Surfactant preparations for preterm infants with respiratory distress syndrome: past, present, and future. Korean J Pediatr. 2019; 62(5):155–161. PMID: 30744318.

3. Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, et al. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012. JAMA. 2015; 314(10):1039–1051. PMID: 26348753.

4. Kim JK, Chang YS, Sung S, Park WS. Mortality rate-dependent variations in the survival without major morbidities rate of extremely preterm infants. Sci Rep. 2019; 9(1):7371. PMID: 31089251.

5. Shim JW, Jin HS, Bae CW. Changes in survival rate for very-low-birth-weight infants in Korea: comparison with other countries. J Korean Med Sci. 2015; 30(Suppl 1):S25–S34. PMID: 26566354.

6. Lee JH, Noh OK, Chang YS. Korean Neonatal Network. Neonatal outcomes of very low birth weight infants in Korean Neonatal Network from 2013 to 2016. J Korean Med Sci. 2019; 34(5):e40. PMID: 30718992.

7. Chang YS, Park HY, Park WS. The Korean Neonatal Network: an overview. J Korean Med Sci. 2015; 30(Suppl 1):S3–11. PMID: 26566355.

8. The Executive Committee of Korean Neonatal Network. 2020 Korean Neonatal Network Annual Report. Cheongju, Korea: Korea National Institute of Health;2021.

9. Lee SM, Chang YS, Park WS. Korean Neonatal Network. International perspectives: implementation of the Korean Neonatal Network. Neoreviews. 2019; 20(4):e177–e188. PMID: 31261059.

10. The Executive Committee of Korean Neonatal Network. 2013 Korean Neonatal Network Annual Report. Cheongju, Korea: Korea Centers for Disease Control and Prevention;2014.

11. The Executive Committee of Korean Neonatal Network. 2014 Korean Neonatal Network Annual Report. Cheongju, Korea: Korea Centers for Disease Control and Prevention;2015.

12. The Executive Committee of Korean Neonatal Network. 2015 Korean Neonatal Network Annual Report. Cheongju, Korea: Korea Centers for Disease Control and Prevention;2016.

13. The Executive Committee of Korean Neonatal Network. 2016 Korean Neonatal Network Annual Report. Cheongju, Korea: Korea Centers for Disease Control and Prevention;2017.

14. The Executive Committee of Korean Neonatal Network. 2017 Korean Neonatal Network Annual Report. Cheongju, Korea: Korea Centers for Disease Control and Prevention;2018.

15. The Executive Committee of Korean Neonatal Network. 2018 Korean Neonatal Network Annual Report. Cheongju, Korea: Korea Centers for Disease Control and Prevention;2019.

16. The Executive Committee of Korean Neonatal Network. 2019 Korean Neonatal Network Annual Report. Cheongju, Korea: Korea Centers for Disease Control and Prevention;2020.

17. Jeon GW, Oh M, Chang YS. Definitions of bronchopulmonary dysplasia and long-term outcomes of extremely preterm infants in Korean Neonatal Network. Sci Rep. 2021; 11(1):24349. PMID: 34934085.

18. Kamitsuka MD, Horton MK, Williams MA. The incidence of necrotizing enterocolitis after introducing standardized feeding schedules for infants between 1250 and 2500 grams and less than 35 weeks of gestation. Pediatrics. 2000; 105(2):379–384. PMID: 10654959.

19. Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Paul Chan RV, Berrocal A, et al. International Classification of Retinopathy of Prematurity, Third Edition. Ophthalmology. 2021; 128(10):e51–e68. PMID: 34247850.

20. Volpe JJ. Intraventricular hemorrhage in the premature infant--current concepts. Part I. Ann Neurol. 1989; 25(1):3–11. PMID: 2913926.

21. Chow SS, Creighton P, Chambers GM, Lui K. Report of the Australian and New Zealand Neonatal Network 2019. Sydney, Australia: Australian and New Zealand Neonatal Network;2021.

22. Boghossian NS, McDonald SA, Bell EF, Carlo WA, Brumbaugh JE, Stoll BJ, et al. Association of antenatal corticosteroids with mortality, morbidity, and neurodevelopmental outcomes in extremely preterm multiple gestation infants. JAMA Pediatr. 2016; 170(6):593–601. PMID: 27088897.

23. Travers CP, Clark RH, Spitzer AR, Das A, Garite TJ, Carlo WA. Exposure to any antenatal corticosteroids and outcomes in preterm infants by gestational age: prospective cohort study. BMJ. 2017; 356:j1039. PMID: 28351838.

24. Chawla S, Natarajan G, Shankaran S, Pappas A, Stoll BJ, Carlo WA, et al. Association of neurodevelopmental outcomes and neonatal morbidities of extremely premature infants with differential exposure to antenatal steroids. JAMA Pediatr. 2016; 170(12):1164–1172. PMID: 27723868.

25. Beltempo M, Shah P, Yoon EW, Chan P, Balachandran N. The Canadian Neonatal Network™ Annual Report 2020. Toronto, Canada: Canadian Neonatal Network™;2021.

26. Cheong JL, Doyle LW. An update on pulmonary and neurodevelopmental outcomes of bronchopulmonary dysplasia. Semin Perinatol. 2018; 42(7):478–484. PMID: 30401478.

27. Kono Y. Neonatal Research Network of Japan. Neurodevelopmental outcomes of very low birth weight infants in the Neonatal Research Network of Japan: importance of neonatal intensive care unit graduate follow-up. Clin Exp Pediatr. 2021; 64(7):313–321. PMID: 33171036.

28. Bassler D, Shinwell ES, Hallman M, Jarreau PH, Plavka R, Carnielli V, et al. Long-term effects of inhaled budesonide for bronchopulmonary dysplasia. N Engl J Med. 2018; 378(2):148–157. PMID: 29320647.

29. Sung SI, Lee NH, Kim HH, Kim HS, Han YS, Yang M, et al. The impact of surgical intervention on neurodevelopmental outcomes in very low birth weight infants: a nationwide cohort study in Korea. J Korean Med Sci. 2019; 34(43):e271. PMID: 31701701.

30. Malviya M, Ohlsson A, Shah S. Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants. Cochrane Database Syst Rev. 2003; (3):CD003951. PMID: 12917997.

31. Malviya MN, Ohlsson A, Shah SS. Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants. Cochrane Database Syst Rev. 2013; 2013(3):CD003951.

32. Peaceman AM, Mele L, Rouse DJ, Leveno KJ, Mercer BM, Varner MW, et al. Predicition of cerebral palsy or death among preterm infants who survive the neonatal period. Am J Perinatol. 2022.

33. Flannery DD, Edwards EM, Puopolo KM, Horbar JD. Early-onset sepsis among very preterm infants. Pediatrics. 2021; 148(4):e2021052456. PMID: 34493539.

TOOLS

Similar articles