As the size of the geriatric population increases, the number of elderly patients diagnosed with painful degenerative diseases of the lumbar spine requiring surgery is expected to rise concomitantly. Many patients require lumbar spinal fusion surgery with instrumentation along with decompression to treat the degenerative lumbar disease. Often, patient age is a major factor in deciding to which extent surgeries could or should be performed, and it is perceived that morbidity is increased with extensive surgeries in older patients32). The geriatric population may be at increased risk for complications because of age and age-associated medical conditions. However, there is a lack of studies addressing the perioperative complications in elderly patients with decompression, arthrodesis of the lumbar spine, and the post operative outcomes of lumbar spinal fusion surgeries24). A review of literature reveals controversy over the safety of lumbar spinal fusion surgery in the elderly due to varying findings on the risk. Several researchers raised concerns over increased morbidity, cautioning against spinal surgery in the older population3,17). The goal of this study was to evaluate; 1) the complication rate in relation to perioperative complications, general factors such as age, sex, comorbidity, American Society of Anesthesiologists (ASA) class, and fusion segments involved, and 2) examine the clinical outcomes of lumbar spinal fusion surgery for degenerative lumbar diseases for patients 70 years and older in contrast to patients younger than 65 year of age.

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The number of elderly persons in the Republic of Korea continues to grow; by 2050, 38.2% of the population is expected to be older than 65 years, greatly exceeding the worldwide mean of 16.2%. An aging population will consequently suffer from age-related degenerative diseases, such as disorders of the spine. Advances in anesthesiology, spinal instrumentation, and postoperative care have made spinal procedures safer, with a decrease in morbidity and mortality, as well as continued improvements in patient outcomes6). Recognizing predictors of complications or poor outcome for the geriatric population is crucial for perioperative risk assessment and applying appropriate preventative procedures. If symptoms of degenerative spinal diseases persist after conservative treatments, surgical treatments may be considered5,9,15).

Similar to several previous retrospective studies, the complication rate in this analysis was 16.7%2,8). In a review of 105 spine surgery articles, Nasser et al.22) reported an overall pooled complication incidence of 16.4%. At 2.6% incidence rate, the most common perioperative complication observed in this study was wound dehiscence. Re-operation after a spinal fusion surgery may be considered a failure of the initial surgery by the patient and the surgeon. It also represents an additional procedure in patients who are already at significant risk for complication6). Mok et al.21) recently evaluated the need for revision surgery in patients undergoing adult spine surgery, finding a cumulative rate of 25.8%, while Cloyd et al.6) reported a re-operation rate of 27.4% in patients at least 65 years old who presented with a wide range of spine pathologies. Recently, Lee et al.20) reported that the rate of revision surgery due to complications was approximately 47%. In our study, the rate of revision surgery due to complications was approximately 40.6%, but age was not associated with the need for re-operation.

Okuda et al.23) found that patients older than 70 years who underwent posterior lumbar interbody fusions for spondylolisthesis had a complication rate of 16%, which was not significantly different from that in younger patients. Kilinçer et al.18) agreed that age did not affect the complication rates of posterior lumbar interbody fusion, but they did not report a complication rate separately for older patients. Vitaz et al.33) suggested that elderly patients with lumbar spinal diseases can be surgically treated in the same manner as the younger patients.

On the other hand, Deyo et al.8) researched retrospective analysis of a statewide hospital discharge registry, in which more than 18000 hospitalization data were complied over a two-year period, excluding patients with nondegenerative pathologies, authors reported an overall complication rate of only 10.3% for the surgical treatment of degenerative lumbar spine disease, although the rate for patients older than 75 years was higher (18%). In a different study, Cloyd et al.6) indicated an alarming 24.2% of elderly patients presented a major postoperative complications, and 53.2% showed at least one in-hospital complication; the authors found that age was a risk factor for major postoperative complications. Recently, Lee et al.20) retrospectively investigated 489 patients with various lumbar spinal diseases who had lumbar spinal fusion surgeries and showed a difference between the older (70 years and older) and younger patients (under 65 years old); the complication rate of the older group was 9%, while that of the younger group was 6%. However, in this study, medical complications were excluded. Our data further supports the statistically significant difference in peri-operative complication rate between the older and young groups; the complication rate of the older group was 20.8%, while that of the younger group was 14.8% (univariate analysis, p=0.015; multivariate analysis, p=0.024).

The mortality rate of 0.6% in the elderly group studied by Deyo et al.8) was approximately three times greater than the rates commonly cited for lumbar diskectomy. Silvers et al.31) reported a mortality rate of 0.8% for mortalities that occurred 1 to 2 months after the surgeries. In our study, one patient (0.2%) died three days after the surgery due to an AMI (Table 4). The deceased patient had AMI history as a comorbidity. The operation was performed on Level 1 (L4-5), and duration was 196 minutes. The blood loss was 350 cc, comparatively less than the mean blood loss, and a transfusion was not necessary. There were no variances during or post operation in the status of the patient. This study's mortality rate of 0.2% is lower than other reported rates.

The relationship between comorbidities and surgical outcome has been historically controversial. Early studies examining the effect of age on decompression with fusion for lumbar stenosis affirmed that the multiple comorbidities were associated with perioperative complications17,25,30). Katz et al.18) reported that cardiovascular, musculoskeletal, and other comorbidities led to poorer scores in most of the outcome measurements. However, for lumbar spinal fusion surgeries in the elderly, several recent studies have found the opposite to be true1-4,18). In the study by Lee et al.20), perioperative complications were not significantly associated with comorbidities. The results of our study indicated that for lumbar spinal fusion surgeries, presence of comorbidities was not associated with perioperative complications (univariate analysis, p=0.132; multivariate analysis, p=0.325). Also, our study revealed that ASA classifications were not statistically significant (univariate analysis, p=0.376; multivariate analysis, p=0.513).

Elderly patients who are diagnosed with symptomatic spinal pathology may require single or expansive lumbar fusions to ensure adequate fusion and inhibit future instrumentation-related complications6). Several studies have proposed that longer fusion lengths may lead to an increased risk of complications in the elderly3,4,27). Carreon et al.3) found an OR of 2.4 for postoperative complications in older patients undergoing lumbar arthrodesis with instrumentation. Similarly, Cassinelli et al.4) reported that fusion of four or more segments was a predictor of complications. The mean number of levels fused in these studies was 2.4 and 1.9, respectively. On the other hand, Daubs et al.7) studied patients 60 years and older who underwent spinal arthrodesis with a mean of 9.1 levels fused and found no association between the length of fusion and complication risk. Moreover, Glassman et al.10) advised that extending the fusion length may actually improve clinical outcomes in correcting poor sagittal balance or spinal cord compression. In our study, there was no significant association between the number of segments fused and the risk of perioperative complications in patients of all ages, including the elderly (univariate analysis, p=0.297; multivariate analysis, p=0.446).

Our last followed outcome based on MacNab's criteria concluded that 412 (85.0%) out of 485 people had excellent or good results since they have resumed their daily activities with minimal, if any, pain. The results for MacNab's criteria in age group 1 (70 years and older) and 2 (younger than 65 years) were 82.2% and 86.5%, showing only a small difference. These results are comparable with those in other reports of favorable outcomes, not only in the elderly, but in patients younger than 70 years as well. Lee et al.19), reported a study with 30 patients who underwent PLIF (mean age 53.53±6.6). The analysis of MacNab's criteria results showed 10% as "excellent" and 66.7% as "good". In a similar study by Sakeb and Ahsan28), a total of 52 cases (11 men and 41 women, mean age 46 years SD 05.88, range 40-59 years) were analyzed on the outcome one year after PLIF surgeries. The reported MacNab's criteria results were 55.77% "excellent" and 38.46% "good". Hur et al.14) examined 20 patients (mean age 70 years) who underwent laminectomy and fusion. The MacNab's criteria analysis at 6 months after operation had outcomes of 7% "excellent" and 86% "good". Sanderson and Wood29) indicated excellent or good results in 81% of their patients 65 years of age or older during an average follow-up period of 42 months. Silvers et al.31) reported that 93% of the patients in their study (average age, 65 years) had relief of pain, and that 5% returned to activity in the short-term outcome analysis. Herkowitz and Kurz12) also reported a 96% rate of excellent or good results during an average follow-up period of 3 years for patients with a mean age of 65 years (range, 30-87 years) who received decompression and arthrodesis for degenerative spondylolisthesis. Johnsson et al.16) agreed with excellent or good results in approximately 60% of the patients in their study with a mean age 61.3 years (range, 48-80 years). Postacchini et al.26) reported excellent or good results for 67% of the patients during an average period of 8 years (range, 4-21 years). Lastly, Hall et al.11) reported excellent or good results during a mean follow-up period of 4 years in 84% of patients, whose mean age was 63 years (range, 32-83 years).

While the findings of the current study are important, there are several limitations. First, as this is a retrospective analysis, for which the limitations are well known, results may underestimate the actual complication incidence. It is common in retrospective studies for investigator recall bias to be introduced, whereby the accuracy of medical records may lead to falsely low reported rates of complication13). Second, there are opportunities for several other biases. Given the significant complexity of the patient population, the current study population may not represent the spine surgery population as a whole. Therefore, these findings may not be applicable to the general spinal fusion surgery patients.

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Increasing age was an important risk factor for perioperative complications in patients undergoing lumbar spinal fusion surgery, whereas other factors were not significant. However, patients' satisfaction or return to daily activities when compared with younger patients does not show much difference. We recommend good clinical judgment as well as careful selection of geriatric patients for lumbar spinal fusion surgery.

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