Abstract
Background
Methods
Results
Supplementary Materials
Notes
ACKNOWLEDGMENTS
REFERENCES
Table 1.
Characteristic | US population in NHANES (n=11,000)a | Korean population in KNHANES (n=18,560)a | |
---|---|---|---|
Age, yr | 47.7±0.39 | 47.3±0.24 | |
Women, % | 51.8 | 50.2 | |
BMI, kg/m2 | 29.6±0.18 | 24.0±0.04 | |
BMI/obesity status (based on USA/Asian criteria) | |||
BMI <25/BMI <23 kg/m2 | 28.5/17.3 | 65.0/42.6 | |
25≤ BMI <30/23≤ BMI <27.5 kg/m2 | 31.0/27.0 | 29.3/42.8 | |
30≤ BMI <40/27.5≤ BMI <35 kg/m2 | 32.3/36.9 | 5.5/13.7 | |
BMI ≥40/BMI ≥35 kg/m2 | 8.2/18.8 | 0.1/0.8 | |
Waist (women/men), inches | 38.7±0.23/40.4±0.21 | 30.9±0.06/33.9±0.05 | |
Hypertension, % | 38.7 | 28.6 | |
Prehypertension, % | 42.8 | 41.6 | |
SBP/DBP, mm Hg | 123.7±0.32/71.2±0.37 | 117.7±0.19/75.8±0.12 | |
Family history of DM, % | 42.0 | 23.3 | |
Known DM, % | 12.1 | 7.7 | |
Known kidney disease (kidney weak, failure, or dialysis), % | 3.2 | 0.26/0.06–0.21b | |
Physically inactive, % | 58.3 | 57.0 | |
Gestational diabetes (among women), % | 6.6 | Unavailable | |
Current smoker, % | 24.1 | 21.4 | |
Alcohol, light or moderate/heavy, % | 46.9/26.3c | 34.2/16.7c | |
Anemia treatment, % | 3.8 | Unavailable | |
Hemoglobin, g/dL | 14.2±0.04 | 14.2±0.02 | |
Cardiovascular disease, % | 7.4 | 3.6 | |
(Congestive) heart failure, % | 2.3 | Unavailable | |
Proteinuria, % | 9.9 | 12.7 | |
Outcomes-related | |||
Fasting glucose (at least 8 hours), mg/dL | 109.6±0.61 | 99.8±0.23 | |
Hemoglobin HbA1c, % | 5.7±0.02 | 5.6±0.01 | |
2-hour glucose, mg/dL | 117.1±1.28c | Unavailable | |
DM (based on lab tests), % | 11.0 | 10.0 | |
Pre-DM (based on lab tests), % | 31.5 | 34.3 | |
Undiagnosed DM (no. of newly diagnosed DM/no. of total DM), % | 20.1 | 34.1 | |
Creatinine, mg/dL | 0.87±0.005 | 0.83±0.002 | |
eGFR, mL/min/1.73 m2 | 94.9±0.58 | 97.8±0.23/98.9±0.23d | |
eGFR <60 mL/min/1.73 m2, % | 6.8 | 2.7/2.9d |
Values are presented as mean±standard error.
NHANES, National Health and Nutrition Examination Survey; KNHANES, Korea National Health and Nutrition Examination Survey; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycosylated hemoglobin; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate.
a Before excluding known/already diagnosed DM and chronic kidney disease (CKD) cases. Sample sizes (number) are unweighted, while other summary statistics are weighted (following NHANES/KNHANES analysis guidelines),
b Left/right values are because weak kidney was not asked/when we included eGFR <15 to <30 mL/min/1.73 m2 (note that creatinine was missing among 707 participants in KNHANES),
d Left/right values are when USA/Korean Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulas were used. See Appendix 1 for variable definitions.
Table 2.
USA-DM score in NHANES (428 DM cases, n=8,928; AUC=0.753) |
K-DM score in KNHANES (791 DM cases, n=16,209; AUC=0.766) |
||||
---|---|---|---|---|---|
Predictor (assigned score) | OR (95% CI) | P valueb | Predictor (assigned score) | OR (95% CI) | P value |
Age, yr | Age, yr | ||||
40–49 (1) | 2.68 (1.83–3.93) | <0.001 | 35–44 (2) | 3.07 (2.00–4.71) | <0.001 |
50–59 (2) | 4.65 (3.25–6.64) | <0.001 | ≥45 (3) | 5.27 (3.54–7.84) | <0.001 |
≥60 (3) | 4.96 (3.52–6.99) | <0.001 | c | ||
Male (1) | 1.29 (1.05–1.58) | 0.012 | c | ||
Hypertension (1) | 1.49 (1.20–1.86) | <0.001 | Hypertension (1) | 2.03 (1.74–2.38) | <0.001 |
Family DM (1) | 1.29 (1.06–1.58) | 0.013 | Family DM (1) | 1.83 (1.55–2.15) | <0.001 |
BMI, kg/m2 | Waist, inches | ||||
25–29.9 (1) | 1.23 (0.90–1.69) | 0.194 | 30–32.9/33–34.9 (F/M) (2) | 1.77 (1.40–2.23) | <0.001 |
30–39.9 (2) | 2.65 (1.99–3.53) | <0.001 | ≥33/35 (F/M) (3) | 3.84 (3.13–4.72) | <0.001 |
≥40 (3) | 3.83 (2.63–5.59) | <0.001 | c | ||
Physically inactive (1) | 1.36 (1.09–1.69) | 0.006 | Current smoker (1) | 1.43 (1.18–1.73) | <0.001 |
Gestational DM, women only (1) | 2.46 (1.53–3.95) | <0.001 | Alcohol, drinks/day | ||
Light or moderate, 1–4.9 (1) | 0.92 (0.77–1.11) | 0.387 | |||
Heavy, ≥5 (2) | 1.17 (0.95–1.44) | 0.137 |
DM, diabetes mellitus; NHANES, National Health and Nutrition Examination Survey; AUC, area under the receiver operating characteristic (ROC) curve; KNHANES, Korea National Health and Nutrition Examination Survey; OR, odds ratio; CI, confidence interval; BMI, body mass index.
a NHANES 2015–2018 and KNHANES 2016–2018 among adults (≥19 year old) were used. For DM, known DM were excluded. Prediction equations are in Supplementary Table 4,
Table 3.
USA-CKD score in NHANES (664 CKD cases, n=9,890; AUC=0.893) |
K-CKD score in KNHANES (653 CKD cases, n=17,803; AUC=0.912) |
||||
---|---|---|---|---|---|
Predictor (assigned score) | OR (95% CI) | P value | Predictor (assigned score) | OR (95% CI) | P value |
Age, yr | Age, yr | ||||
50–59 (2) | 5.54 (3.10–9.90) | <0.001 | 50–59 (2) | 5.41 (2.79–10.5) | <0.001 |
60–69 (3) | 20.3 (12.1–34.0) | <0.001 | 60–69 (3) | 17.1 (9.31–31.2) | <0.001 |
≥70 (4) | 73.3 (44.3–121) | <0.001 | ≥70 (4) | 59.9 (33.2–108) | <0.001 |
Female (1) | 1.19 (0.99–1.42) | 0.065 | Female (1) | 0.74 (0.62–0.88) | <0.001b |
Hypertension (1) | 1.50 (1.21–1.87) | <0.001 | Hypertension (1) | 2.24 (1.81–2.76) | <0.001 |
DM (1) | 1.12 (0.92–1.35) | 0.264c | DM (1) | 2.00 (1.67–2.39) | <0.001 |
Anemia (1) | 2.04 (1.48–2.81) | <0.001 | Anemia (1) | 4.09 (3.36–4.99) | <0.001 |
CVD (1) | 1.54 (1.23–1.92) | <0.001 | CVD (1) | 1.36 (1.07–1.73) | 0.011 |
CHF or HF (1) | 1.65 (1.20–2.27) | 0.002 | d | ||
PAD (1) | Unavailable | d | |||
Proteinuria (1) | 1.89 (1.54–2.33) | <0.001 | Proteinuria (1) | 2.32 (1.88–2.85) | <0.001 |
CKD, chronic kidney disease; NHANES, National Health and Nutrition Examination Survey; AUC, area under the receiver operating characteristic (ROC) curve; KNHANES, Korea National Health and Nutrition Examination Survey; OR, odds ratio; CI, confidence interval; DM, diabetes mellitus; CVD, cardiovascular disease; CHF, congestive heart failure; HF, heart failure; PAD, peripheral artery disease (or circulation problems in legs in the questionnaire).
a NHANES 2015–2018 and KNHANES 2016–2018 among adults (≥19 year old) were used. For CKD, known kidney failure/disease were excluded. Prediction equations are in Supplementary Table 4,
b When Korean Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) was used, there were 697 CKD cases, and “female” showed OR, 1.10 (95% CI, 0.93 to 1.31; P=0.27 and AUC=0.907),
c Is due to multicollinearity; DM showed unadjusted OR, 2.95 (95% CI, 2.50 to 3.48; P<0.001), and OR, 1.23 (95% CI, 1.02 to 1.48; P=0.029) when proteinuria was excluded. For DM, total DM (i.e., diagnosed and undiagnosed together) was used. When only known/diagnosed DM was used, results did not change materially; beta coefficient was slightly attenuated but AUC was unchanged (i.e., second or third decimal point change),
Table 4.
Model, population | % of high score | Se | Sp | PPV | NPV | LR+ | LR– | Youden | AUC | |
---|---|---|---|---|---|---|---|---|---|---|
Outcome: undiagnosed DM (cutpoint ≥5 for high risk) | ||||||||||
USA-DM score, in NHANES | 48 | 84 | 53 | 8 | 99 | 1.79 | 0.30 | 37 | 0.75 | |
USA-DM score, in KNHANES | 31 | 67 | 70 | 10 | 98 | 2.23 | 0.47 | 37 | 0.78 | |
K-DM score, in KNHANES | 57 | 89 | 45 | 8 | 99 | 1.62 | 0.24 | 34 | 0.77 | |
K-DM score, in NHANES | 72 | 93 | 29 | 6 | 99 | 1.31 | 0.24 | 22 | 0.71 | |
USA-DM score for DM/pre-DM, in NHANESb | 49 | 70 | 66 | 59 | 76 | 2.06 | 0.45 | 36 | 0.73 | |
USA-DM score for DM/pre-DM, in KNHANESb | 31 | 48 | 82 | 68 | 67 | 2.67 | 0.63 | 30 | 0.75 | |
Outcome: undiagnosed CKD (cutpoint ≥4 for high risk) | ||||||||||
USA-CKD score, in NHANES | 39 | 94 | 65 | 16 | 99 | 2.69 | 0.09 | 59 | 0.89 | |
USA-CKD score, in KNHANES | 38 | 96 | 64 | 9 | 100 | 2.67 | 0.06 | 60 | 0.91 | |
K-CKD score, in KNHANES | 38 | 96 | 64 | 9 | 100 | 2.67 | 0.06 | 60 | 0.91 | |
K-CKD score, in NHANES | 39 | 94 | 65 | 16 | 99 | 2.69 | 0.09 | 59 | 0.89 |
DM, diabetes mellitus; CKD, chronic kidney disease; Se, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value; LR+, likelihood ratio positive; LR–, likelihood ratio negative; AUC, area under the ROC curve; NHANES, National Health and Nutrition Examination Survey; KNHANES, Korea National Health and Nutrition Examination Survey.
Appendix
Appendix 1.
Variable definitions using NHANES and KNHANES
NHANES, National Health and Nutrition Examination Survey; KNHANES, Korea National Health and Nutrition Examination Survey; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; HbA1c, glycosylated hemoglobin; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; MDRD, Modification of Diet in Renal Disease; KDIGO, Kidney Disease: Improving Global Outcomes.