A 30-year-old male patient received an above-elbow amputation about eight months prior to seeing us for an open fracture on the left radius and ulna due to trauma. He ended up transferring from one department to another department since his condition did not improve at all during treatment due to constant and severe pain after the amputation surgery. We could not find any specific findings in this medical history. He kept complaining about cramping pain on his removed arm and electric-like pain occurring once every few minutes. He also said that he felt the entire shape of his removed arm, and it was medially rotated. Every day, he was prescribed gabapentine (2,400 mg), oxycodon (200 mg), and amitriptyline (25 mg), with other medications to control the pain. However, the degree of his pain relief was somewhat insignificant and the visual analog scale (VAS) was 8-10 out of 10. Other treatment methods, such as stellate ganglion block, thoracic sympathetic ganglion block, brachial plexus block, cervical transforaminal epidural block, and a subcutaneous infusion of ketamine, were also done. However, they gave the patient only short-term improvement. Lastly, spinal cord stimulation (SCS) was done for the patient, but the treatment effect was very insignificant.

Finally, we performed mirror therapy for the patient. He had to visit the hospital four times a week and went through a 15-minute treatment period. We had the patient feel the movement of his removed arm and hand just like his normal arm and hand moving through a mirror (Fig. 1). After a week passed, the patient said that he could feel his medially rotated arm was back to normal, and his VAS level decreased to 7 out of 10. One month later, he said that the previous cramping pain was almost gone and the phantom hand and arm returned to normal. At that time, his VAS level was 5 out of 10. After, three month from the initial therapy, he is doing a mirror therapy three to four times a week at home. However, the electric like pain remains and the VAS usually is maintained at 4 out of 10. He is under follow-up at our outpatient department with oxycodon decreased to 100 mg a day.

No treatment for phantom limb pain has yet been clearly proven in terms of its effect. Drug therapy includes narcotic drugs, anti-epileptic medications, topical anesthesia, and analgesics. An infusion of ketamine, a N-Methyl-D-aspartic acid receptor antagonist, was also introduced for phantom limb pain treatment [6]. Meanwhile, non-drug therapy includes sympathetic ganglion block, transforaminal epidural block, peripheral nerve block, transcutaneous electrical nerve stimulation (TENS), direct cortical or spinal cord stimulation, and mirror therapy, etc. One of the most effective treatments is mirror therapy.

Mirror therapy was unveiled by Ramachandran and Rogers-Ramachandran in 1996. Under this therapy, a patient is allowed to feel the imaginary movement of the removed body part behaving as normal body movement through a mirror [7]. The mirror image of the normal body part helps reorganize and integrate the mismatch between proprioception and visual feedback of the removed body. Thus, enhancing the treatment effect for phantom limb pain. The clinical effect of mirror therapy is much more significant than any other treatments [4,8].

Rizzolatti used a mirror neuron to explain the fundamentals of a mirror therapy [9]. At first, a mirror neuron was found in the monkey premotor cortex, and later, Rossi discovered that humans also have similar mirror neurons systems [10]. A mirror neuron fires both when a person acts and when a person observes the same action performed by another. Then, the neuron mirrors the behavior of the other, as though the observer were itself acting. A mirror neuron provides observers with internally recognized experiences, making them understand other's behaviors, intentions, and emotional status [9,10]. Therefore, while mimicking the behavior of the other, observers can experience not only the sensation, but also the similar emotion of the other. In this sense, a patient with phantom limb pain can feel the same sense or emotion of his/her normal body part by observing the mirror image. By doing so, it is expected to decrease pain by resolving conflict between motor intention, proprioception and visual system.

Not all observing activities are accompanied by these sensory experiences of a mirror neuron. A person without phantom limb pain and no amputations cannot feel these sensory experiences since the signs from a non-mirror neuron block the mirror neuron, while a patient with an amputation does not have this non-mirror neuron system operating [11]. The visual observation can help feeling empathy, which explains how the mirror therapy works for a patient.

The effect of the mirror therapy varies depending on the pain. It is reported that the therapy is more effective on deep somatic pain (e.g., pressure sense and proprioceptive pain) than on superficial pain (e.g., warmth sense and nociceptive pain). This is because deep tissues are responsible for integrating sensorimotor nerves as well as creating movements compared to superficial tissues [12].

Recently, mirror therapy has used for not only patients with phantom limb pain, but also for patients with complex regional pain syndrome and strokes [13,14]. Many studies indicate that mirror therapy is only effective for upper limb treatment, but it has potential as alternative treatment for pain that is difficult to control.

In this study, mirror therapy resulted in dramatic pain relief for a patient with chronic phantom limb pain when other treatments such as medications, physical therapies, nerve blocks, nerve transformations did not work. Mirror therapy is expected to be widely used for the treatment of phantom limb pain since it is easy to use at both home and in outpatient departments.