A 44-year-old male patient visited the hospital. He claimed low back pain at right, buttock pain, and thigh pain at upper front with fever that occurred 6 days ago. He had got physical therapy and medicinal herbs treatment for a long time in the oriental medical clinic because of low back pain. In recent, he got additional pharmacopuncture treatment several times until 6 days before visiting this hospital. Right after the pharmacopuncture treatment, the symptom was improved, but he got a fever and the degree of pain got worse for 6 days before visiting this hospital. At first in this hospital, the patient claimed that he felt stiff in the lumbar at right side, buttocks, and thigh at upper front and he said they were numb. The degree of pain was 6/10 on visual analogue scale (VAS). The pain was sustained all day without being relieved even though taking a rest. It got worse when bending over or straightening his back, and it was greatly serious at night, so he claimed sleep disorders. The specific medical history of the patient, which can cause infection disease was not identified.

In the physical examination, tenderness was detected in spinous process of lumbar spine at level 2, 3, 4, and the right paraspinal area. There was no particular opinion in other neurologic examination or physical examination. High fever of 39.7 degrees was shown but other vital signs such as blood pressure and pulse were normal. In blood test, white blood cell count was 7,300/µl, which is in normal range, and erythrocyte sedimentation rate and C-reactive protein were respectively 67 mm/hr, 97.44 mg/L. AST/ALT/γGT were 92/151/226 IU/L, and ALP increased to 152 IU/L.

There was no particular opinion in simple radiography of lumbar spine, but in MRI for checking lesion, a wide range of myositis and multiple abscess in paraspinal muscles and psoas muscle between right lumbar spine at level 3-5, including multifidus muscle, longissimus muscle, iliocostal muscle, quadratus lumborum muscle, psoas muscle were detected (Fig. 1). With blood culture, about 3 cc thick pus was aspirated (Fig. 2) from three abscess sites (Fig. 3) under ultrasound needle guide and it was cultured. Except for it, there was no particular opinion in simple radiography of chest, ECG, echocardiography, and urine test.

Before obtaining the results from culture, 3^rd generation antibiotic cefazolin and gentamicin were injected under being admission. As a result of incubation, staphylococcus aureus was identified, and cefazolin and gentamicin treatment which sensitivity checked were maintained. From the 4^th day after admission, the fever came down significantly, the symptom was improved, and the patient's condition was stabilized. The patient discharged after replacing with levofloxacin which is the oral antibiotic 12 days after admission. Since then, the patient's condition was improved, but the treatment sustained for 1-month more with the oral antibiotic and it was closed.

There has been a lot of controversy over clinical usefulness of acupuncture [3], but traditional chinese medicine has a deep-rooted tradition, so acupuncture is widely used nationally. According to Witt et al. [4], it is known that the incidence of complications due to acupuncture amounts to about 7%, and 1.9% of them needed for treatment. Complications include pain, bleeding, infection related to procedure, and direct damages to nerves and organs due to acupuncture [4,5]. Moreover, infection of diseases such as AIDS [6] or hepatitis type B [7] are reported. In particular, infection is one of the complications regarding acupuncture, which is occurred not infrequently [8]. It is estimated the incidence will be increasing, considering the reality that complications regarding traditional chinese medicine treatment are not reported appropriately nationally.

It is not easy to find the reports on complications related to pharmacopuncture which is widely used in recent. As for pharmacopuncture, more complications might be triggered than simple acupuncture because there are complications not only related to acupuncture but related to used medicinal herbs. Even for infection, the incidence will be increasing because it might be caused not only by acupuncture itself but by used medicinal herbs.

The causes of acupuncture itself include inappropriate management of needles for treatment, inappropriate dressing of needle injection sites, and hand sanitation of the operator. Especially, there are reports that abscess is occurred even after using disposable needles [9], as well as reusing the needle after disinfection. It seems to be related to the fact that generally acupuncture tends to be applied to the injection sites with the bare hands without the specific disinfection, that's why it is required to derive the solutions for dressing of the injection sites and hand sanitation of the operator.

Medicinal herbs used for pharmacopuncture treatment are not medical supplies which are produced, distributed and controlled by thorough standardization or sterilization. Medicinal herbs for pharmacopuncture are not inspected on their aseptic property and safety, and are not controlled properly. And they are made by each different method of the operator at discretion. In this regard, regardless the effectiveness of medicinal herbs for pharmacopuncture, it is required to secure at least safety on medicinal herbs as soon as possible for public health.

It is quite difficult to detect pyogenic abscess of deep muscle at the initial stage [10], so patients tend to be suffered from the pain in various parts such as lumbar, flank, or buttocks commonly 5-6 days later on. The symptom is subacute by deep infection, which occurred rarely, and generally it is occurred in single part of muscle but it might be occurred in a wide range of parts for 11-43% [11]. As to the patients with low back pain, it is common that acupuncture is applied up to deep muscle near the spine, so it is possible to invade spine or the surrounding parts [12]. In case the appropriate management are not taken, fatal complications such as necrotizing fasciitis, septicemia, and death might be caused [9,11]. In this case, medicinal herbs which unclear ingredients are contained were injected through thin tube after applying acupuncture to the wide parts several times without thorough dressing, that's why multiple abscess in deep muscle was occurred.

In conclusion, it is definitely possible that serious infection is occurred by acupuncture without applying the inspected medicinal herbs or equipments or following thorough aseptic technique. Therefore, in case of symptoms such as fever and nonspecific low back pain, whether there is an invasive procedure like acupuncture including pharmacopuncture should be checked out and the possibility of infection at the initial stage should be prevented before triggering fatal complications. In addition, it is thought that health authorities should play a vital role in controlling infection of acupuncture and preparing the solutions.