Abstract
Malignant tumors rarely occur in the paranasal sinuses. Paranasal tumors, when they occur, exhibit atypical symptoms, such as nasal obstruction, rhinorrhea, facial pain, and nasal bleeding. Because of nonspecific symptoms commonly observed in the sinusitis and their infrequent occurrence, malignant tumors of the paranasal sinuses are generally diagnosed late. If there is bone destruction or invasion of the surrounding tissues in the imaging studies, malignant tumors could be suspected; however, without such findings, it is difficult to predict the existence of cancer. It is more difficult to suspect malignant tumors when they coexist with sinus diseases. In addition, since the concomitant presence of fungal balls and cancer is extremely rare, it is difficult to suspect the presence of cancer when treating fungal balls. We report a case of a fungal ball accompanied by squamous cell carcinoma without any sign of malignancy, such as bone destruction, which has not been reported in the English literature to date.
Malignant tumors in the sinuses account for approximately 5% of all head and neck malignancies and occur annually in approximately 1 per 100000 individuals worldwide [1]. The mean age at onset is 50-60 years, and symptoms are atypical, such as nasal obstruction, facial pain, rhinorrhea, and nasal bleeding [2]. They are usually diagnosed after the disease progresses because the symptoms or signs are similar to those of benign paranasal sinus diseases. Therefore, approximately 10-20% of patients have lymph node metastasis at the first diagnosis [3]. The most common type of tumor is squamous cell carcinoma (SCC, 50-80%), followed by adenocarcinoma (10-20%).
Approximately 13.5% to 28.5% of maxillary sinusitis is associated with fungal sinusitis [4]. The most common form of fungal infection is a fungal ball, which consists of a dense conglomeration of hyphae separated from the sinus mucosa. Fungal balls do not have histological evidence of fungal invasion of the mucosa, blood vessels, or bone when visualized microscopically [5].
Fungal balls and SCC are rarely observed together in the paranasal sinuses. Ginat, et al. [6] reported a case of a concurrent fungal ball and SCC of the maxillary sinus. Since their patient showed disproportionate destruction of the maxilla bone on radiological imaging and progressive symptoms despite the treatment for infection control, the possibility of malignancy could be assumed. We report a case of a fungal ball accompanied by SCC without any sign of malignancy, which has not been reported in the English literature to date.
A 67-year-old man was admitted to our clinic with rhinorrhea and nasal obstruction of the left nasal cavity that had developed approximately 1 month ago. He did not have symptoms such as facial pain, swelling, bleeding, or foul odor. There was no underlying disease except allergic rhinitis in his past history. Although he underwent treatment of dental caries in the right lower first molar 6 months ago, there was no history of dental problem in the upper molar area. Endoscopic examination showed a nasal polyp and mucopurulent discharge in the left nasal cavity (Fig. 1). CT of the paranasal sinuses showed soft tissue density and calcification in the left maxillary sinus, which is consistent with signs of a fungal ball (Fig. 2). There was no feature that was suspicious of malignancy, such as destruction and invasion of the surrounding structures. Endoscopic sinus surgery was planned under local anesthesia for histopathologic diagnosis and treatment with the suspicion of a fungal ball.
A polyp-like mass of the left nasal cavity was removed, and antrostomy was performed. Mucopurulent clay-like material consistent with a fungal ball was found in the left maxillary sinus. Severe edema was observed in the maxillary mucosa, and biopsy was performed (Fig. 3). Histopathologic examination revealed the diagnosis of a nasal polyp and fungal ball consisting of Aspergillus (Fig. 4A) in the nasal cavity and left maxillary sinus, respectively, as expected. However, unexpectedly, edematous mucosal tissue of the posterior maxillary sinus was confirmed as SCC (Fig. 4B).
Positron emission tomography for identification of the primary site and distant metastasis was performed and confirmed stage II (T2N0M0) SCC originating from the left maxillary sinus. The patient underwent concurrent chemotherapy consisting of 7260 cGy/33 times radiation therapy in the left maxillary sinus. Positron emission tomography performed 6 months postoperatively showed slightly increased mucosal uptake in the left maxillary sinus, which is a finding corresponding to benign inflammation. No metastases or recurrences were found. Nineteen months after the surgery, a new lesion involving the left ethmoid sinus and orbit was identified. Gamma knife treatment was applied, and no remnant or recurrence have been observed for a year during follow-up.
Fungal balls, which are non-invasive accumulations of dense conglomerations of fungal hyphae, usually present in sinus cavities. They occur mainly in the maxillary sinus, but can be observed in other sinuses and rarely in more than one sinus [7]. Since most patients with fungal balls are asymptomatic due to the characteristic slow growth of such balls, they are usually detected incidentally and diagnosed late [4]. Common symptoms of fungal balls include unilateral purulent discharge, postnasal drip, facial pain, and nasal obstruction. Nasal bleeding, facial pain, and ocular or neurologic symptoms can also be observed.
Diagnosis is based on symptoms of recurrent or refractory sinusitis and typical CT findings including inhomogeneous opacification with central metallic dense spots in the unilateral sinus. Since bone erosion is shown in 4-17% of cases of fungal balls [8], accompanied cancer may not be predicted when CT shows bone destruction preoperatively. In particular, in fungal ball cases, if there are no symptoms such as bone erosion or pain, cancer is more difficult to be suspected before surgery. In this case, we could not predict the cancer before surgery because there were no findings that were suspicious of malignancy. Furthermore, we also did not suspect cancer during surgery because the intraoperative findings did not have any suspicious features of cancer such as surrounding tissue invasion or a mass. SCC was diagnosed incidentally in a biopsy specimen performed to examine the invasion of fungus or the extent of eosinophils and neutrophils in the mucosa. Based on this case, it is recommended to perform histologic examination of the mucosa with severe inflammation in endoscopic sinus surgery, especially in elderly patients.
SCC may occur first, causing inflammation, resulting in poor ventilation and inappropriate immune mechanisms, resulting in a fungal ball. Although the type of tumor is different, Yeo, et al. [9] reported a case of coexistence of small cell carcinoma and fungal ball in the maxillary sinus. They assumed that fungus entered into the maxillary sinus through nasal breathing and was captured in the sinus by mass effect of small cell carcinoma. The tumor might block the ostium of maxillary sinus and cause an anaerobic condition in which the fungus could be colonized. Therefore, it was presumed that fungal ball was secondary to small cell carcinoma. Although it occurred in different sites, Itano, et al. [10] reported a case of non-small cell lung cancer coexisting with pulmonary aspergilloma. They hypothesized that the progression of the lung cancer obstructed the bullous air spaces, resulting in the colonization of Aspergillus and occurrence of pulmonary aspergilloma.
However, it is more likely that the fungal ball caused inflammation for a long period in this patient because a polyp and osteitic change of the maxilla bone were observed. In addition, cancer can be caused by inflammation; thus, it is presumed that cancer occurred because of long-term inflammation caused by the fungal ball. However, since there is no apparent evidence that fungus directly induces cancer, it is difficult to elucidate the causal relationship between a concurrent fungal ball and SCC in the paranasal sinuses.
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