With an aging population that continues to grow, many patients have cardiovascular risk factors or preexisting cardiovascular disease at the time of non-cardiac surgery. Among various diagnostic imaging modalities for cardiovascular disease, transthoracic echocardiography is one of the most popular methods for preoperative cardiac risk stratification because it can simultaneously evaluate cardiac structures and the function of the heart [1]. Moreover, it is safe, reproducible, cost-effective, and easy to perform. Thus, echocardiography is used widely and its potential applications are increasing with advances in technology. Appropriate knowledge regarding indications for echocardiography in the current guidelines, applications of echocardiography in real clinical practice, and a correct understanding of commonly encountered echocardiographic findings might help to manage patients in the perioperative period, and occasionally rescue patients from acute manifestations of overt cardiovascular diseases, such as decompensated heart failure or cardiogenic shock.

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Current guidelines, in fact, do not recommend routine transthoracic echocardiography for the evaluation of cardiac function before non-cardiac surgery. Table 1 summarizes the recommendations for echocardiography before non-cardiac surgery in several guidelines. The British Society of Echocardiography guidelines [2], published in April 2013, comprehensively stated the clinical indications for echocardiography for elective and semiurgent surgery. In this guideline, four indications are specified: (1) documented ischemic heart disease with reduced functional capacity (< 4 metabolic equivalents [METs]), (2) unexplained shortness of breath in the absence of clinical signs of heart failure if the electrocardiogram and/or chest X-ray is abnormal, (3) murmur in the presence of cardiac or respiratory symptoms, and (4) murmur in an asymptomatic individual in whom clinical features or other investigations suggest severe structural heart disease. To meet these indications, we need a properly taken history showing any previous ischemic heart disease and an accurate physical examination, including auscultation. In fact, today, primary physicians' and trainees' ability to hear cardiac murmur may be poor, as various imaging modalities have been developed. In real clinical practice in Korea, many hospitals have their own practical standards for performing preoperative echocardiography before non-cardiac surgery. For example, in elderly patients without a completely normal electrocardiogram or chest X-ray, many physicians request preoperative echocardiography. However, repeated assessments versus a previous echocardiogram with no intervening change in clinical status and routine preoperative echocardiography are not indicated.

In the guidelines of the American Society of Echocardiography [3], there is no clear defined indication for resting echocardiograms. Additionally, the American College of Cardiology/American Heart Association (ACC/AHA) guidelines published in 2014 defined the indications for echocardiography in a different way [4]. It is recommended that patients with clinically suspected moderate or greater degrees of valvular stenosis or regurgitation undergo preoperative echocardiography if there has been (1) no prior echocardiography within 1 year, or (2) a significant change in clinical status or physical examination since the last evaluation. It is reasonable for patients with dyspnea of unknown origin to undergo preoperative evaluation of left ventricular (LV) function. It is also reasonable for patients with heart failure with worsening dyspnea or other change in clinical status to undergo preoperative evaluation of LV function. Reassessment of LV function in clinically stable patients with previously documented LV dysfunction may be considered if there has been no assessment within 1 year. However, also in these guidelines, routine preoperative evaluation of LV function is not recommended.

Under consideration of appropriate indications of preoperative echocardiography in a few current guidelines, we should apply echocardiography in cost- and time-effective ways in clinical practice. Thus, the next step is to assess individual risk based on the planned, non-cardiac surgical procedures and to exclude active cardiac conditions that are required to undergo evaluation and treatment before non-cardiac surgery.

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Cardiac complications after non-cardiac surgery depend on patient-related risk factors and on the type of surgery [56]. Thus, before considering a preoperative cardiac evaluation, including echocardiography, individual cardiac risk related to the surgical procedures should be assessed [7]. Three factors that must be considered are listed in Table 2 [8].

Patient-related factors include age, presence of chronic disease, functional status, medical history, and the presence of implantable devices or prior surgical history. Regarding functional status, a history of daily activities for individuals must be taken. If the patient can climb a flight of stairs or walk up a hill, his or her metabolic equivalent is > 4 METs. If the patient can participate in strenuous sports like swimming, singles tennis, football, baseball, or skiing, his or her metabolic equivalent is > 10 METs. The inability to walk ≥ 2 blocks on level ground or run a short distance (< 4 METs) indicates poor functional capacity and is associated with an increased incidence of post-operative cardiac events [910]. Information about functional capacity is important in deciding whether to do additional stress testing. It is reasonable for patients who are at an elevated risk for non-cardiac surgery and have poor functional capacity (< 4 METs) to undergo non-invasive pharmacological stress testing (dobutamine stress echocardiography or pharmacological-stress nuclear imaging) under the ACC/AHA guidelines. Advanced age adversely affects the rates of cardiac and non-cardiac complications and mortality, as well as length of stay. Perioperative mortality risk was in the intermediate range (2.6% in patients > 80 years vs. 0.3% in patients 50–59 years of age, P = 0.02) according to the results from a prospective cohort analysis by Polanczyk et al. [11] in Brigham & Women's Hospital. However, there is no reported evidence that routine preoperative evaluation using echocardiography can improve perioperative outcomes in elderly patients.

Surgery-related factors include the type of surgery, urgency status, surgical duration, and the possibility of blood loss and fluid shifts. Table 3 shows the cardiac risk stratification based on surgical procedures. Vascular procedures, such as aortic and other major vascular surgery are at a high cardiac risk because the reported cardiac risk is often > 5% [1213]. However, endoscopic procedures, superficial procedures, cataract surgery, breast surgery, and common ambulatory surgeries are at a low cardiac risk (< 1%) [1415]. Most elective non-cardiac surgeries are at an intermediate cardiac risk (1–5%).

Finally, before considering specific tests, we need to consider test-related factors. Patients, their family members, and even surgeons usually believe that the sensitivity and specificity of a specific test for cardiac evaluation are 100%. Although this is not true, if the results from some specific cardiac test are normal, they simply consider the patient's heart condition to be normal. For example, while there is no regional wall motion abnormality and normal LV ejection fraction in resting transthoracic echocardiography, there are still possibilities for acute coronary syndrome, such as unstable angina or non-ST elevation myocardial infarction on the LV. Thus, we need to understand the potential limitations of non-invasive tests, know the sensitivity and specificity to identify specific cardiovascular diseases, and consider the effects on management.

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Although the risk stratification of patients before non-cardiac surgery in stable condition is valuable in preventing cardiac events in the perioperative period, the most important purpose of preoperative screening is excluding active cardiac conditions. Table 4 displays four categories of active cardiac conditions [16]. If the patient has one of these conditions, the elective non-cardiac surgery should be delayed until the patient is out of the condition and has become stable.

The four conditions are unstable coronary syndromes, decompensated heart failure, significant arrhythmia, and severe valvular disease. To define the presence of severe valvular disease, quantitative measurements of valvular hemodynamics by echocardiography are essential. Additionally, to recognize the three conditions except severe valvular disease, echocardiography is not necessary but valuable in defining the underlying cause(s), assessing the severity of each condition, evaluating the treatment response, and predicting the prognosis.

Today, as the aged population grows, the incidence of severe aortic stenosis due to degenerative causes will increase. Severe aortic stenosis is defined according to an integrative approach taking into account valve area (< 1.0 cm² or 0.6 cm²/m² body surface area, except in obese patients), and flow-dependent indices (maximum jet velocity of 4 m/s and mean aortic pressure gradient of ≥ 40 mmHg) [17]. It is often detected during preoperative cardiac evaluations. Among the various valvular diseases, severe stenotic disease at the aortic valve may affect the clinical course seriously during general anesthesia and/or after non-cardiac surgery [18]. Severe aortic stenosis is a well-established risk factor for perioperative mortality and myocardial infarction [7]. In cases of urgent non-cardiac surgery in patients with severe aortic stenosis, such procedures should be performed under more invasive hemodynamic monitoring, avoiding rapid changes in volume status and heart rhythm as much as possible. In the case of elective non-cardiac surgery, the presence of symptoms is essential for decision-making [19]. In symptomatic patients, aortic valve replacement should be considered before an elective surgery [19]. In patients at high risk or contraindicated for aortic valve replacement, transcatheter aortic valve implantation may be a reasonable therapeutic option before surgery [2021]. In asymptomatic patients, non-cardiac surgery of low-to-intermediate risk can be performed. If possible, the absence of symptoms should be confirmed by exercise testing. If high-risk surgery is planned, further clinical assessment is needed to assess the risk of aortic valve replacement [7].

In terms of mitral stenosis, asymptomatic mitral stenosis is not absolutely contraindicated but symptomatic mitral stenosis should be treated by percutaneous mitral valvuloplasty or mitral valve replacement [7]. However, even in asymptomatic patients with significant mitral stenosis, systolic pulmonary artery pressure over 50 mmHg is a risk factor for clinical deterioration in perioperative periods. Additionally, combined atrial fibrillation or tachycardia may cause serious clinical deterioration. Thus, use of β-blockers or calcium channel blockers to keep a sufficient diastolic filling time may be helpful in preventing perioperative decompensated heart failure.

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If patients do not have an active cardiac condition, those at risk for major adverse cardiac events before non-cardiac surgery still need to be identified. To stratify cardiac risk, the ACC/AHA have created a classification of non-cardiac surgical procedures, as shown in Table 3 [3]. In fact, procedures in the intermediate category cover a wide range of surgical procedures and carry a 1–5% risk of adverse cardiac events. Thus, clinical risk factors such as a prior history of heart disease, compensated or prior heart failure, cerebrovascular disease, diabetes mellitus, and renal insufficiency should be dealt with cautiously if the procedures are in the intermediate risk categories. If a patient has three or more risk factors, a comprehensive cardiovascular evaluation should be considered before non-cardiac surgery. However, if there are one or two clinical risk factors, a preoperative cardiac evaluation is recommended at the physician's discretion.

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Table 5 lists commonly encountered findings in preoperative echocardiography and their clinical interpretation. These findings are somewhat helpful for risk stratification for future cardiovascular events. Although many of these findings are only subclinical abnormalities or incidental findings, each has potential clinical implications. Additionally, if there are some discrepancies between individual's symptoms and echocardiographic findings, clinical correlations by cardiologists or experienced anesthesiologists are important. For example, if a patient complains of exertional dyspnea but there are no remarkable findings on resting echocardiography, further functional assessments using exercise tests should be considered.

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There are various types of stress testing for evaluating ischemic heart disease. Stress echocardiography using exercise or pharmacological (dobutamine, dipyridamole) stress has been used widely in preoperative cardiac risk evaluations. The test combines information on LV function at rest, heart valve abnormalities, and the presence and extent of stress-induced ischemia [722]. However, before non-cardiac surgery, stress testing is mostly focused on the diagnosis and risk stratification of coronary artery disease. For patients with elevated risk and poor (< 4 METs) or unknown functional capacity, exercise or non-invasive pharmacological stress testing for myocardial ischemia is recommended if it will change management. However, routine screening with non-invasive stress testing is not useful for patients at low risk for non-cardiac surgery [315].

When stress testing is required to detect myocardial ischemia, which stress test should be used? Generally, most ambulatory patients commonly undergo a treadmill stress test, but exercise echocardiography or nuclear imaging is preferred in patients with abnormal resting electrocardiograms, including LV hypertrophy strain pattern or digitalization effects. In addition, patients unable to exercise or patients with left bundle branch block on an electrocardiogram should preferably undergo dobutamine stress echocardiography or nuclear imaging. Thus, the stress mode should be selected depending on the clinical situation to reach an appropriate diagnosis.

A previous meta-analytic comparison of preoperative stress echocardiography and nuclear scintigraphy imaging by Beattie et al. [23] demonstrated that stress echocardiography had better negative predictive characteristics than thallium imaging in a comparison of 3,373 subjects who underwent stress echocardiography in 25 studies with 6,827 subjects who underwent thallium imaging in 50 studies. Thus, the conclusion was that stress echocardiography was superior to thallium imaging in predicting postoperative cardiac events. Generally, stress echocardiography has a high negative predictive value and a negative test is associated with a very low incidence of cardiac events in patients undergoing surgery. In another meta-analysis of six non-invasive tests by Kertai et al. [24], dobutamine stress echocardiography showed a positive trend towards better diagnostic performance versus the other tests, including ambulatory electrocardiogram, exercise electrocardiogram, radionuclide ventriculography, dipyridamole stress echocardiography, and myocardial perfusion scintigraphy.

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Recently, interest in focused echocardiography has increased for evaluating cardiac status effectively for a specific goal. Particularly, increased availability, portability, and imaging capabilities of current transthoracic echocardiography equipment has enabled treating physicians to perform their own ‘focused echocardiography’ as an aid to an initial clinical assessment at the point of care, when required. For example, aortic stenosis, common in the hip fracture population, and pulmonary hypertension are significant risk factors for mortality, but diagnosis is unreliable without echocardiography. Thus, focused echocardiography may provide a more accurate assessment than a physical examination alone. Attractively, it is usually performed at the patient's bedside as a point of care.

A prospective observational study by Canty et al. [25] discussed focused transthoracic echocardiography in 99 patients who had suspected cardiac disease or were ≥ 65 years old. Focused echocardiography included only a few important points of LV or right ventricular failure, valve stenosis, or regurgitation of at least moderate severity, pericardial effusion greater than 0.5 cm, and estimated pulmonary arterial systolic pressure > 60 mmHg. In that study, cardiac disease was identified by echocardiography in 64% of patients, which led to a step-up of treatment in 36% (4% delayed for cardiology referral, 2% altered surgery, 4% intensive care, and 25% intra-operative hemodynamic management changes). Absence of cardiac disease in 36% resulted in a step-down of treatment in 8% (3% no referral, 1% intensive care, and 4% hemodynamic treatment). Although further studies are warranted, focused echocardiography is a valuable method for preoperative cardiac risk stratification.

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In the current guidelines, routine preoperative cardiac evaluation by echocardiography is not recommended for everyone, given the considerations of cost-effectiveness and time delay for non-cardiac surgery. Preoperative echocardiography has become more popular in clinical practice because it can provide clinically useful information about a patient's cardiac risk. Thus, understanding the commonly encountered echocardiographic findings and clinical interpretations are helpful for managing patients in the perioperative period.

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