A 40-year-old male with intermittent chest pain and dyspnea on exertion underwent elective cardiopulmonary bypass (CPB) surgery for MR and partial obstruction of the LVOT diagnosed by 2D-TTE. He underwent a patch-closure procedure for an atrioventricular septal defect (AVSD) 10 years previously. The intraoperative 2D-TEE midesophageal long-axis (ME-LAX) view showed a band-like structure vertically traversing the middle of the LVOT, connecting the anterior mitral leaflet (AML) base and the interventricular septum, and tethering the base of the AML anteriorly. These 2D-TEE images suggested that more than half the LVOT area was obstructed by this band-like structure (Fig. 1 and Video 1). However, additional 3D-TEE (X7-2t™and iE33™; Philips Healthcare, Bothell, WA, USA) images consisting of an en face view of the LVOT (Video 2) and cropped and rendered 2D images provided more comprehensive information to understand the pathophysiology and anatomic relationship of LVOT structures, including the AML and interventricular septum; this information was quite different from that provided by 2D echocardiography. The web-like tissue in the parietal band region of the interventricular septum was asymmetrically obstructing the right corner (posteromedial aspect) of the LVOT. However, the peak velocity and peak pressure gradient of the LVOT were about 80 cm/s and 2.6 mmHg in pulsed-wave Doppler analyses in the deep transgastric view. The degree of obstruction confirmed in the en face view of the LVOT seen from the left ventricle (LV) perspective showed that the band-like structure was partially tethering the base of the AML, but it was not traversing the center of the LVOT; the narrowest part of the LVOT and subaortic region measured as approximately 2.3 cm² using a multiple cross-sectional cropping process in the 3D-TEE software (Q-lab™, MVQ™ and i-slice™, Philips, San Jose, CA, USA) (Fig. 2 and Video 3).

After initiating CPB, the direct surgical view under surgical exposure of a left atriotomy confirmed the folded and slightly bulged web-like tissue, which partially obstructed the posteromedial aspect of the LVOT, as shown in the 3D-TEE image. The tissue had grown around the patch closure used for a previous AVSD. The redundant patch applied during the previous AVSD closure was removed and replaced with a new pericardial patch, and the abnormally grown web-like tissue was resected (Fig. 3). As a lifting annuloplasty (augmentation of the posterior leaflet), plication of the posterior annulus was performed by suturing a flexible ready-to-use strip (Mitra-Lift™; Sciencity, Seoul, Korea) onto the atrial wall above the posterior annulus between both commissures. After the surgical procedure, the peak pressure gradient of the LVOT was about 2.2 mmHg. The 2D- and 3D-TEE images after weaning from CPB revealed a fully widened LVOT (2.8 cm² on 3D planimetry), resolution of the AML tethering, and incomplete MV coaptation producing mild MR (Fig. 3 and Video 4).

LVOT obstruction requiring reoperation can rarely occur after AVSD correction. In case of LVOT obstruction after AVSD correction, in 83%, it was diagnosed 2 to 14 years postoperatively. Thus, postoperative follow-up echocardiography is important to early detection of LVOT obstruction resulted from various causes [2]. In the present case, web-like tissue grew abnormally around a patch that had been used for a previous AVSD closure. It occupied the corner of the LVOT, was tethered to the base of the AML, and partially contributed to the MR. However, preoperative and intraoperative 2D echocardiographic evaluations were insufficient for providing a comprehensive understanding of the associated cardiac pathology. The degree of obstruction determined by 2D echocardiography suggested that the band/web-like structure had completely obstructed the entire LVOT. These 2D findings were not matched well to the severity of the obstruction indicated by the Doppler velocity profile, the patient's symptoms, or the direct surgical findings.

Conventional 2D echocardiographic imaging provides limited information in a single slice tomographic image and requires the examiner to mentally reconstruct through an understanding of the structural relationships of 3D cardiac structures. The authors concluded that the 2D ME-LAX image was not appropriately aligned in the center of the LVOT, as it deviated slightly to the posteromedial side. Various 2D images taken in various tomographic planes and their integration are necessary for a comprehensive understanding of complex cardiac pathology, as in the present case. However, since the image planes of TEE tomography are limited and parallel to the orientation of the cardiac axis, it is difficult to align the image planes to accurately and appropriately visualize the tubular and elliptical LVOT structure; even use of multiple 2D-TEE images is occasionally insufficient for a thorough evaluation of complex cardiac pathology [3].

In contrast, 3D-TEE showed that additional clinical efficacy by making a comprehensive spatial image from 2D images [4]. The ability of 3D-TEE to produce volume images (dataset) of objective cardiac structures enables dimensionless cardiac imaging in the true anatomic perspective by freely modifying the volume image through rotation, cropping, and rendering, which facilitates decision making [5]. It could be possible for surgeons to confirm the LVOT pathology, seen from one side of the LV or aorta perspective, through the direct inspection after atriotomy or aortotomy. However, 3D-TEE images enables the anesthesiologist to observe the both sides that LV and aortic valve perspective by rotating the volume images. In the present case, a single 3D-TEE en face high quality image seen from the LV perspective provided precise LVOT anatomy, comparable or superior to that seen by a surgeon during a surgical procedure. This image enabled a more accurate and rapid evaluation of the pathology, as shown in previous studies [345678]. These precise and prompt pre-procedural evaluation may also be facilitate surgical procedure by preventing the potential intraoperative delay due to identification of the discrepancy between the pr-procedural diagnosis and surgical inspection [8].

Real-time 3D imaging also benefits surgeons by facilitating faster and more accurate communication for decision making; just "seeing" a single 3D image displayed on the TEE monitor enabled their comprehensive understanding. Gripari et al. [1] demonstrated that a surgeon can detect the cardiac pathology on 3D-TEE images more easily and accurately compared with corresponding 2D images.

In conclusion, the present case showed that intraoperative 3D-TEE enabled a more rapid and accurate assessment of complex pathology resulting in an LVOT obstruction with MR. Although intraoperative 2D-TEE imaging is sufficient in most clinical situations, the information obtained from additional 3D-TEE imaging can be of enormous benefit for surgical planning and post-surgical follow up.