The main goal of weaning from cardiopulmonary bypass (CPB) is a smooth transition from mechanical pump-assisted circulation to spontaneous heart activities with sufficient blood flow to maintain systemic circulation. Before initiation of weaning from the CPB, optimal condition for re-beating should be prepared. Normothermia (core temperature > 36℃) is achieved by actively re-warming through the CPB heat exchanger, active warming devices. However, core temperature should not be exceeded by more than 38℃ to avoid postoperative neurological dysfunction [1]. The findings of laboratory data should be within normal ranges. Arterial blood gas analysis is carried out to identify oxygen content of the blood as hematocrit (> 25%), hemoglobin (> 7 g/dl), PaO₂ (> 100 mmHg) and absence of metabolic, electrolytic disturbances. The anesthesiologists restart sleeping alarms and adjust monitors, ventilator settings and oxygen flows. After aortic declamping, heart re-beat spontaneously in most cases with minor supportive interventions such as electrical defibrillation, pace maker, and small dose of inotropics. Atrial kick contributes more than 20% of ventricular filling, returning and maintaining of normal sinus rhythm (heart rate between 70-100 beats per min) is preferable. Electric conversion of supraventricular tachycardia, atrial fibrillation and temporary cardiac pacing for atrioventricular conduction block should be considered. Optimized preload is achieved by volume control, mean arterial pressure maintained within 70-90 mmHg with vasoactive agents. In case of inability to wean from CPB despite preload optimization, global cardiac function and completeness of surgery should be assessed by transesophageal echocardiography (TEE) examination. Most common causes of weaning difficulty are left and/or right ventricular failures and inappropriate vasodilatation. TEE allows diagnostic and therapeutic decision makings, and appropriate treatment option. Routine TEE examinations before terminating the CPB is essential for detecting unexpected problems such as an iatrogenic aortic dissection from arterial cannulation site or intracardiac thrombus formations even after full heparinization or any other anatomical anomalies [2,3]. Because of major complication of TEE probe insertion is the esophageal injury, anesthesiologists carefully manipulate TEE probe, especially patient with an esophageal pathology preoperatively [4]. Faultiness of surgery should be excluded (valvular dysfunction, coronary graft failure, left ventricular outflow obstruction) by TEE examinations, and vasoplegic syndrome managed by vasopressor administration [5]. The recently emerged minimally-invasive hemodynamic monitoring devices can assess the cardiac output, preload, intrathoracic volume and tissue oxygenation which might be guide weaning management with real time inspections of responsiveness of fluid loading and vasoactive agents [6]. Patients with risk factor of ventricular dysfunction (elderly, chronic beta-blocker treatment, renal failure, pulmonary hypertension) tend to be difficult in weaning from CPB, awareness of these risk factors are important for preparing and planning aggressive cardiosupportive management earlier as prophylactic intervention [7]. Protamine sulfate is administrated slowly in order to neutralize generalized heparinization. Thromboelastography as a point-of-care monitoring device can provide rapid information about global hemostatic states (from clot formation, stabilization to fibrinolysis) to achieve goal oriented transfusions during the cardiac operation [8].