Although OIH is a curious concept, the mechanisms of OIH are not clearly understood. The links between opioid tolerance and OIH are also obscure, though some tried to adapt their mechanical discrimination recently to their clinical reports [1,2]. The mechanisms of OIH have been postulated in two ways [3]. One is the cellular-level adaptation in desensitization, internalization, downregulation and heterodimerization. The others are the system-level adaptations in descending facilitation, upregulation of spinal dynorphins, neuroplasticity in the rostral ventromedial medulla and dorsolateral funiculus of the spinal cord, downregulation of glutamate transporters and activation of N-methyl-D-aspartate (NMDA) receptors. Multifactorial mechanisms demonstrate that multimodal efforts to attenuate OIH may be necessary to handle this issue in clinical setting. Multimodal efforts to prevent OIH has been reported, including ketamine [4], nitrous oxide [5], magnesium [6], and pregabalin [7-9]. Moreover, the opioids that are not only µ opioid receptor-mediated but also another mechanism-mediated, such as methadone and buprenorphine, seldom demonstrate OIH. Although a lack of novelty, nothing new in pregabalin can attenuate OIH perioperatively, Lee et al. [10] tried to investigate the changes of threshold of mechanical nociceptive stimuli in each group using Von Frey filaments. They also demonstrated that pregabalin can attenuate OIH in aspect to not only clinically relevant pain but also mechanically evoked pain. Opioids remain the most powerful pain killers for acute pain management. Opioids are the prerequisite for perioperative analgesia but OIH can be the other side of the sword. The continuous interest in OIH and optimized treatments for its prevention will increase the quality of perioperative life.