Abstract
Purpose
Materials and Methods
Results
Electronic Supplementary Material
Notes
Ethical Statement
This retrospective study was approved by the Institutional Review Board of the Seoul National University Hospital (IRB No. H-1611-016-805). Informed consent was waived due to the retrospective nature of the study.
Author Contributions
Conceived and designed the analysis: Wee CW, Kim JH.
Collected the data: Wee CW, Jeong CW, Kwak C, Kim HH, Ku JH, Kim SH, Cho JY, Kim SY.
Contributed data or analysis tools: Wee CW, Jang BS, Jeong CW, Kwak C, Kim HH, Ku JH, Kim SH, Kim SY.
Performed the analysis: Wee CW, Jang BS, Kim JH.
Wrote the paper: Wee CW, Jang BS, Kim JH.
References
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Fig. 1
![crt-2020-1221f1.gif](/upload/SynapseXML/0036crt/thumb/crt-2020-1221f1.gif)
Fig. 2
![crt-2020-1221f2.gif](/upload/SynapseXML/0036crt/thumb/crt-2020-1221f2.gif)
Fig. 3
![crt-2020-1221f3.gif](/upload/SynapseXML/0036crt/thumb/crt-2020-1221f3.gif)
Fig. 4
![crt-2020-1221f4.gif](/upload/SynapseXML/0036crt/thumb/crt-2020-1221f4.gif)
Fig. 5
![crt-2020-1221f5.gif](/upload/SynapseXML/0036crt/thumb/crt-2020-1221f5.gif)
Table 1
Variable | No. (%) |
---|---|
Total | 1,915 (100) |
Age, median (range, yr) | 67 (41–86) |
iPSA (ng/mL) | |
Below 4 | 190 (9.9) |
4–10 | 1,126 (58.8) |
10–20 | 387 (20.2) |
20 or higher | 212 (11.1) |
TRUS-Bx | |
PPC, median (range, %) | 25.0 (5.0–100.0) |
Both lobe involvement | |
Yes | 797 (41.6) |
No | 1,076 (56.2) |
Unknown | 42 (2.2) |
Gleason score | |
6 | 863 (45.1) |
7(3+4) | 389 (20.3) |
7(4+3) | 297 (15.5) |
8 | 277 (14.5) |
9 | 78 (4.1) |
10 | 11 (0.6) |
cTMRI stagea) | |
1c | 243 (12.7) |
2a–2b | 718 (37.5) |
2c | 694 (36.2) |
3a | 110 (5.7) |
3b | 150 (7.8) |
Pathologic findings b) | |
ECE | 702 (36.7) |
SVI | 227 (11.9) |
RM+ve | 719 (37.5) |
Table 2
Variable | ECE | SVI | RM+ve | |||
---|---|---|---|---|---|---|
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β | p-value | β | p-value | β | p-value | |
iPSA (ng/mL) | 0.050 | < 0.001 | 0.037 | < 0.001 | 0.038 | < 0.001 |
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PPC (%) | 0.033 | < 0.001 | 0.024 | < 0.001 | 0.021 | < 0.001 |
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BLI-Bx | 0.359 | 0.009 | −0.003 | 0.988 | −0.177 | 0.161 |
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Gleason scores on biopsy | 0.358 | < 0.001 | 0.753 | < 0.001 | 0.131 | 0.037 |
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cTMRI stagea) | 0.259 | < 0.001 | 0.507 | < 0.001 | 0.149 | 0.006 |
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Constant | −5.486 | < 0.001 | −10.459 | < 0.001 | −2.894 | < 0.001 |
Table 3
BN models | 5-Fold validation metrics | ||
---|---|---|---|
Overall AUCa) | Overall Calibration Index (%) | Overall accuracy (%) | |
ECE | 0.76 | 79.7 | 73.0 |
SVI | 0.88 | 62.6 | 89.6 |
RM+ve | 0.70 | 75.1 | 69.1 |
AUC, area under the curve; BN, Bayesian network; ECE, extracapsular extension, RM+ve, positive resection margin; SVI, seminal vesicle invasion.
a) Interpretation: 0.5, no discrimination; 0.7–0.8, acceptable; 0.8–0.9, excellent; > 0.9, outstanding [19].
Table 4
Node | Normalized mutual information (%) | Relative mutual information (%) | Relative significance | p-valuea) |
---|---|---|---|---|
Node significance to the probability of ECE | ||||
PPC | 8.22 | 8.67 | 1.000 | < 0.001 |
iPSA (ng/mL) | 7.74 | 8.17 | 0.942 | < 0.001 |
Gleason scores of biopsy | 7.56 | 7.97 | 0.920 | < 0.001 |
cTMRI stageb) | 6.63 | 6.99 | 0.807 | < 0.001 |
Both lobe involvement | 2.62 | 2.76 | 0.319 | < 0.001 |
Node significance to the probability of SVI | ||||
cTMRI stageb) | 9.85 | 18.75 | 1.000 | < 0.001 |
Gleason scores of biopsy | 9.02 | 17.17 | 0.916 | < 0.001 |
iPSA (ng/mL) | 7.25 | 13.81 | 0.736 | < 0.001 |
PPC | 7.15 | 13.61 | 0.726 | < 0.001 |
Node significance to the probability of RM+ve | ||||
iPSA (ng/mL) | 6.40 | 6.70 | 1.000 | < 0.001 |
PPC | 5.26 | 5.51 | 0.822 | < 0.001 |
cTMRI stageb) | 3.76 | 3.94 | 0.588 | < 0.001 |
Gleason scores of biopsy | 3.57 | 3.74 | 0.559 | < 0.001 |