Val D'Isere is located in the Rhone-Alpes region (Savoie department) in the southeastern France near to the border of Italy (Fig. 1). Val D'Isere is known as a vacation spot especially in the winter as well as the host of the winter Olympics in 1992. There are two ways from Seoul to get to Val D'Isere: one by bus through Geneva and one by train via Paris (Fig. 1). Several reservation information was listed in a blog [3]. Because there is currently no direct flight from Seoul to Geneva, it is necessary to stopover in Paris or an alternative city. Flight time to Paris is usually about 12 hours and it takes about 1 hour to fly from Paris to Geneva. It takes 4 hours from Geneva international airport to Val 'Isere by bus.

There are two ways of getting a train from Paris to Val D'Isere; one by daytime train and the other by night train. If taking a route by any trains, additional 30 minute bus drive is necessary to travel from Bourg-Saint Maurice to Val I'Isere. Therefore, an overnight stay in Paris needs to be considered in order to get to Val Isere on time or in an appropriate time to get the bus in Bourg-Saint Maurice or to check in hotel in Val I'Disere.

Medical illnesses related to the long trip to Val D'Isere can occur during travelling via flight, train or bus and during the meeting. Respiratory difficulty, nausea or general weakness can occur in high altitude as in the Alps. Frostbite or accident can be other problems because it is generally very cold with frequent heavy snow in Val D'Isere that is located in high altitude. The most common problems in an airplane were syncope or presyncope (37.4% of cases), respiratory symptoms (12.1%), and nausea or vomiting (9.5%) [4]. Another report showed that the most common medical events were transient loss of consciousness (41%), nausea/vomiting/diarrhea (19.5%), and breathing difficulty (16%) [5]. Those events were potentially associated with the stresses of flight; for example, loss of consciousness or syncope may be associated with mild hypoxia and immobility; nausea and vomiting and shortness of breath were likely to be associated with a degree of anxiety-related hyperventilation [5].

There are some interesting findings that in frequent international business travelers short trips cause more problems. More specifically, having higher alcohol consumption over the recommended limit and failing to get the recommended amount of sleep (8 hours per night for an adult) will aggravate the risk of developing such symptoms [6]. Younger travellers fell ill to a greater extent than older travellers. The fact that younger travellers are at an increased risk of travel-related illnesses confirms the results of previous studies [7]. The main illnesses described here included gastrointestinal trouble, headache and sleep disturbance because one of the authors (Suh DC) has experienced similar patterns almost every year.

GI trouble can occur during flight or at the destination and includes various symptoms including abdominal pain, diarrhea, nausea or vomiting. Heavy meal or excessive alcohol intake, ingestion of cold food or unfamiliar food can be the cause of the GI trouble. The GI system expands by 25% under the lower atmospheric pressure in the flight and the oxygen level is lower-[8]. Passengers with constipation can suffer from abdominal pain or distention during the flight. For prevention, it is important to wear comfortable clothes and refrain from excess consumption of food and soft drink. Most people who develop an episode of traveler's diarrhea experience a self-limiting illness with approximately 1 day of disability without further medical complications [9].

Alcohol consumption was more likely on longer flights, when traveling with friends, and anticipating First or Business Class seating [10]. Passengers in an airplane became intoxicated approximately 3 times faster. In the case of drinking gas-evaporating beer or champaign, abdominal distension was frequently reported. This is particularly important for the elderly and patients with chronic disease such as diabetes, and coronary heart disease. Cold food and beverage including dairy products sometimes evoke discomfort of the bowels and also may cause diarrhea. In order to prevent GI trouble, efforts not to consume excess food and alcohol and to avoid cold food and beverage would be helpful [11].

According to an author's experience, headache appeared in the airplane or at the destination after alcohol drinking. The most common and serious situation was headache after drinking of several different kinds of liquor including wines. Different kinds of wine, champaign or beer might aggravate the headache particularly at a destination with high altitude which promotes rapid absorption of alcohol. Sweet things such as chocolate and dairy products such as cheese seemed to be related to headache if taken in a large amount.

Airplane headache is usually a symptom caused by the exposure to rapid change and variation of atmospheric pressure rather than high altitude [12]. The characteristics of pain are diffuse severe, fronto-orbital pain, lasting less than 20 minutes, typically associated with take-off or landing. It is known to be due to failing of the compensation between intra-sinus and external pressure causing barotrauma, which affects ethmoidal nerves from the ophthalmic branch of the trigeminal nerve [13]. Preventative measures are nonpharmacological pressure on the painful area, Valsalva maneuver, increasing fluid intake, reducing amount of alcohol, or taking nonsteroidal anti-inflammatory drugs as pharmacological treatment [14],

The flight motion sickness may be the most common symptom when people f irst get on the flight with feeling of dizziness, nausea, and sometimes severe vomiting. Relieving the psychological stress seems to be important by meditating, taking a deep breath slowly, and achieving peaceful state of mind. Moreover, fastening the seatbelt and wearing comfortable clothes may be helpful. It happens more severely in the status of overeating, overdrinking and starving [14]. Therefore, it is important to keep a record of oral intake before or on board.

Comparison of international business travelers with general population revealed that frequent international business travelers were associated with a lower body mass index, lower blood pressure, excess alcohol consumption, sleep deprivation, and diminished confidence to keep up with the pace of work [15]. Circadian or diurnal rhythm is a biological process that displays an endogenous oscillation of about 24 hours. During a trip abroad, there will be a time difference and the circadian rhythm is temporally interrupted. This will inevitably affect sleep pattern or mood state, resulting in sleep disturbance [16]. To overcome this, traveler can adjust exposure time to sunlight to maintain circadian rhythm because the amount of melatonin secretion in the body is controlled by exposure time to the sunlight. Sleeping pill may be helpful but is generally not recommended [15].

A sound sleep is required especially when an important presentation is scheduled the next day. In those situations, minimal amount of sleeping pill would be enough to adapt to jet lag if there is a sleep disturbance. One of the authors could sleep well after taking only a small dose of sleeping pill (a half of Zolpidem 6mg tablet). One of the authors experienced that putting a bandage over his eyes induced a good quality sleep in the airplane or at night because various light sources hinder a good quality sleep.

Homesickness defined as the distress or impairment caused by an actual or anticipated separation from home with preoccupying thoughts of home and attachment objects. Homesickness can make travelers experience depression and anxiety, withdrawn behavior, and diff iculty focusing on topics unrelated to home. However, homesickness about food of his or her hometown and social customs are particularly problematic when travelers cannot adjust the local food. Strategies to overcome this include combinations of environmental information, psycho-education, social support, explicit coping instruction, caregiver education, practice time away from home, and surrogate caregiver training.

GI trouble, headache and sleep disturbance were the most common travel-related illnesses associated with a long trip such as from South Korea to Val D'Isere for an academic congress. Although good meals and beverages are required for a pleasant journey excessive consumption of food and alcohol can disturb the physical and mental wellbeing of travelers. Therefore, refraining and exerting self-control regarding food and alcohol and avoiding cold and unfamiliar food are needed. Sleep disturbance due to jet lag can be an obstacle in preparing for and performing academic activities such as presentation and discussion at the congress. Although various preventative and conservative measures can be employed to maintain both physical and mental wellbeing, some medication may be required if not managed conservatively.