Interestingly, the incisive branch of the IAN is not included in Terminologia Anatomica published by the Federative International Programme for Anatomical Terminology (FIPAT), which prescribes international anatomical terminology.

The incisive branch of the IAN has been previously documented under several different names, such as the lingual portion of the anterior mandibular canal, the MIC, incisive canal, incisive nerve canal, the mandibular incisive nerve, as well as the incisive bundle or incisive plexus [6, 7]. In regards to the occurrence and prevalence of the incisive branch, the majority of the literature has relied upon documentation of the MIC and subsequently, its housing of the incisive branch itself, as the MIC has now been widely accepted as a significant anatomical finding [8] despite previous studies having neglected its occurrence [9]. The MIC, with its contained incisive branch, is alternatively referred to as the mandibular incisive nerve and is rarely documented under alternative nomenclature, such as the lingual portion of the anterior mandibular canal as stated above.

The inferior alveolar artery travels with the IAN through the mandible within the mandibular canal. After reaching the interforaminal region, the mandibular canal splits into the MIC and mental canal, with the MIC continuing along the anterior mandible, containing vascular bundles that supply the incisors, canines, mandibular first premolars and associated attached mucosa [10, 11]. Jacobs et al. [12] observed through utilization of high-resolution magnetic resonance imaging (MRI), that the MIC contains its own true neurovascular bundle, as the intraosseous extension of the inferior alveolar neurovascular bundle [13]. Additionally, some have considered that, while the MIC may become indistinct at the level of the central incisors, a neurovascular plexus may exist at the mandibular midline [7].

Traditionally, the incisive branch innervates the ipsilateral mandibular premolars, canines and incisors [1, 11]. However, there have been several reported anatomical variations of the incisive branch that may lead to subsequent deviations from the traditional structural innervation [7]. It has been demonstrated that the incisive branch itself is extensively branched and can cross the midline to innervate the contralateral side of the mandible [14]. It has also been observed that the midline of the body of the mandible may not correspond with the midline of the incisive branch [15]. Additionally, there is considerable variation on which mandibular teeth contain communication between both the mental nerve and incisive branch [1].

The precise location of the bifurcation of the IAN into the mental nerve and incisive branch may vary (Table 1, Fig. 2) [16-19]. For example, the mental nerve may turn superiorly and inferiorly to the location of the bifurcation to exit the mental foramen, forming an anterior loop [4, 20]. The incisive branch and associated MIC travel through the intramedullary space, with the MIC usually located medial to the mental foramen, with a narrowing canal diameter and less cortical bone as it approaches the anterior mandible [9]. The length of the incisive branch has also been suggested to grow in association with loss of mandibular dentition [11].

In an examination of 46 hemi-mandibles, Mardinger et al. [16] demonstrated the mean incisive canal diameter to be 2.09 mm at the mental canal, 1.25 mm near the position of the canines and 0.98 mm near the lateral incisors. In a study of 96 cone-beam computed tomography (CBCT) radiographs taken in anticipation of implant placement conducted by Parnia et al. [17], the diameter of the incisive canal was reported to be 1.47±0.50 mm. The mean distance of incisive canal from the borders of the mandible were found to be as follows: 4.46±1.40 mm from the lingual border, 3.48±1.17 mm from the buccal border and 8.72±1.43 mm from the lower border.

Gilis et al. [18] utilized CBCT to examine the presence, positioning and diameter of the MIC in transverse imaging of 100 hemimandibles. When visualized, the MIC was found to course in a descending manner toward the mandibular symphysis. The average length of the MIC in all groups was found to be 6.65±4.1 mm. A significantly larger horizontal diameter and length of the MIC was demonstrated in edentulous patients and patients over the age of 60 years. Additionally, the MIC was found to be more superficial to the alveolar ridge in this patient population.

Kong et al. [19] obtained 50 CBCT, or 100 hemimandibles, to measure the MIC diameter, length and location within the mandible and found that the diameter of the MIC gradually decreased from origin, from the area of the second premolar tooth, to end, near the central incisor teeth. The horizontal diameter at the origin measured 2.16±0.58 mm and the vertical diameter measured 2.15±0.62 mm, compared to the horizontal diameter of 0.84±0.23 mm and vertical diameter of 0.89±0.34 mm at the end. The authors additionally demonstrated that the distances from the MIC to the lower margin of the mandible at the second premolar and first premolar teeth differed significantly according to sex, with the mean distance from the MIC to the lower margin at the second premolar measuring 11.34 mm in males and 8.75 mm in females. Similarly, the mean distance at the first premolar was 9.44 mm in males and 8.43 mm in females. The mean length of the MIC was found to be 17.84 mm in the left side of the mandible and 17.73 mm in the right side of the mandible.

Several types of imaging modalities have been employed to analyze the incisive branch of the IAN, including cadaveric studies, panoramic radiographs, and CBCT (Fig. 3).

Cadaveric studies have been utilized both as means of direct visualization of the course of the incisive branch of the IAN, as well as to observe the macroscopic content of the MIC. The buccal cortical plate often requires removal before a grinding apparatus can be used to the expose the entire course of the IAN (Fig. 1). The position, length, and diameter of IAN and its associated anatomical structures can then be measured with a digital-sliding caliper [4]. The presence of the incisive branch of the IAN has been detected 100% of the time in several cadaveric studies [4, 15, 21]. While cadaveric studies allow for a better understanding of the presence and anatomical variations of the incisive branch among different populations, these studies alone may be less applicable when applied to a clinical setting. Additional studies have also applied traditional radiographic techniques or CBCT on cadaveric mandibles to further compare dissection and radiographic findings, allowing for a greater understanding of the reliability of the employed radiographic images [15, 21].

Traditional radiographs, such as periapical radiographs, have been used to evaluate the incisive branch; however, these types of radiographs, while efficient and typically taken at the majority of initial dental examinations, do not alone provide enough accurate information for treatment planning purposes. There has been no correlation found between the incisive branch’s anatomical and radiographical findings when utilizing traditional radiographs. This may be attributed to the distortion often associated with radiographic films and is further complicated by variations in the size and uniformity of the bone trabeculae surrounding the MIC [1, 16].

Panoramic radiographs, while commonly utilized as a means of assessing dentition, jawbones, sinuses, and the temporomandibular joints, provide limited information on the incisive branch. Due to the confines of two-dimensional imaging, panoramic radiographs do not display the buccolingual aspect and cross-sectional slices of the MIC and incisive branch. Panoramic radiographs are additionally highly dependent on patient positioning, which may lead to magnification, distortion, and superimposition of anatomical structures. Notably, Jacobs et al. [12] demonstrated that the MIC was only identified in 15% of panoramic radiographs of 545 patients, and clearly visible in only 1% of cases (Fig. 4). A later study by Pires et al. [22] reported similar findings, demonstrating that panoramic radiographs accurately detected the MIC in only 11% of patients. Sahman et al. [23] showed that the MIC was visible 51.2% of panoramic radiographs, however; this group also established that the size of the MIC did not significantly affect its visibility, suggesting that even anatomically large MICs may not be visible in panoramic imaging.

CBCT may provide multiplanar views of high-resolution images at reduced radiation doses when compared to MRI and CT. Consequently, CBCT has been found to be a practical means of detecting and evaluating the incisive branch of the IAN. Sahman et al. [23] demonstrated that the MIC was visible in 94.4% of CBCT radiographs, compared to 51.2% of panoramic radiographs. Pereira-Maciel et al. [24] found that the MIC can be detected bilaterally in 100% of CBCT radiographs. If available, CBCT should be employed as the radiographic imaging modality of choice when planning for any type of surgical procedure involving the anterior mandible given its demonstrated high degree of accuracy in the display of the MIC.

Though the mandibular interforaminal zone has traditionally been considered a low-risk area for implant placement, complications may arise from damage to the MIC and the associated incisive branch, such as hemorrhage and neurosensory disturbance [29, 30]. Lee et al. [29] demonstrated a case of hemorrhage from laceration of the vascular structures contained within the incisive canal during implant osteotomy placement. Kütük et al. [31] conducted a retrospective study to evaluate neuropathic pain caused by implant placement in the interforaminal region of the mandible in relation to the MIC and found that, of the 10 patients that were evaluated for neurosensory disturbances, radiographic imaging confirmed at least 1 MIC perforation by an implant in each patient.

When placing implants in the interforaminal zone, the diameter and direction of the MIC should be verified during the initial treatment planning stages. Drilling during implant placement may lead to injury of the incisive branch, particularly in the case of an incisive branch with a large diameter. This can subsequently lead to stretching of and further damage to the IAN [11]. Patients with a large MIC may be more prone to experiencing higher amounts of intraoperative and post-operative pain, which may even necessitate implant removal [32].

The MIC in elderly and edentulous patients has been found to follow a more internalized and superficial course in relation to the overlying alveolar ridge, making the incisive branch more vulnerable to damage during implant placement in the interforaminal zone. Wismeijer et al. [33] demonstrated permanent sensory deficits in the lower lip in 7% of 110 edentulous patients who received 2 to 4 implants in the interforaminal zone, with each implant placed at least 3 mm away from the mental foramen. It has also been reported that, since the average diameters of the MIC at its origin have been reported to be around 2 mm, overgrowth of connective tissue may prevent implant osteointegration should the implant be placed in a 2-mm cavity [18].

Identification of the MIC by CBCT prior to implant placement should be employed whenever possible as part of the pre-operative planning to assist in avoiding iatrogenic damage to the incisive branch.

Mandibular fractures may result in injury to the IAN, with subsequent sensory disturbances occurring to the lower lip and chin. A review of studies that evaluated neurosensory disturbances following mandibular fractures found that the reported IAN sensory deficit after injury before treatment was 5.4%–81.4%, shortly following treatment was 0.4%–91.3% and after 1 year was 0%–46.6% [34]. Most studies reporting on nerve injuries following mandible fractures and subsequent repair do not specifically focus on damage to the incisive branch and MIC; however, it has been documented that fractures of the IAN-containing posterior mandible are associated with higher risk of both pre- and postoperative sensory disturbances when compared to non-IAN bearing sites. Tay et al. [34] demonstrated that the prevalence of IAN injury in IAN bearing sites was higher by 43.6% before treatment and 41.2% after treatment when compared to non-IAN bearing sites. This group posed that the presence of pre-operative sensory alteration in the anterior mandible may be related to post-traumatic swelling and that post-operative sensory alteration following open reduction-internal fixation (ORIF) may be explained by plating in close proximity to the mandibular foramen.

Displaced fractures of the anterior mandible in the area of the incisive branch and MIC, specifically parasymphyseal and symphyseal fractures, are traditionally treated with ORIF [35]. Two miniplates or one larger plate have generally been accepted as the ideal treatment method. It should be noted that the use of two mini plates has been associated with more postoperative complications, such as infection, wound dehiscence and iatrogenic damage to tooth roots [36]. Two lag screws that span the fracture line may also be used as means of fixation; however, this technique has been associated with reported paresthesia in the mental nerve region of up to 68% of cases, and can be considered to be more technique sensitive [37]. Careful attention to the positioning of the IAN, mental foramen and MIC should be evaluated prior to fracture repair via CBCT if available and during the repair of mandibular fractures to minimize the risk of iatrogenic nerve damage.

There are numerous types of intra-bony lesions that may present as a unilocular lesion of the tooth-bearing portions of the anterior mandible, such as keratocystic odontogenic tumor, radicular cyst, glandular odontogenic cyst, and adenomatoid odontogenic tumor. Central mucoepidermoid carcinoma, a low-grade malignancy, is less likely, but may present as a well-demarcated lesion near the mandibular midline. Developmental entities, such as an anterior Stafne bone defect, may also present in a similar fashion in the anterior mandibular region [38]. Careful attention should be payed to the positioning and presence of the MIC and incisive canal in relation to identification and treatment of anterior mandibular and periapical pathology.

Bilginaylar et al. [39] described the enucleation of a radicular cyst along the area of the left mandibular premolar and subsequent exposure of the incisive branch. Following the exposure, the authors rinsed the cystic cavity with sterile physiologic saline and placed platelet-rich fibrin gel inside the bony defect. The patient did display post-operative paresthesia, which completely resolved after two months. Similar to the above mentioned surgical procedures, the presence, location and dimensions of the MIC should be elicited when planning for the biopsy or removal of any pathology present in the anterior mandible.

Primary bone tumor associated with neural tissue, such as schwannomas, in the anterior mandible is extremely rare [40]. The analysis of 71 cases showed that the majority of the central schwannomas involved with posterior mandible (78%) and only 22% was associated with the anterior mandible [40]. Rengaswamy could not find the relationship between the schwannoma and IAN, and suggested that the origin of the tumor could have been one of the branches of the incisive branch [41].