Journal List > Ann Clin Neurophysiol > v.23(2) > 1147839

Yang, Lee, Sung, Shin, Kim, and Park: Usefulness of infrared thermography in diagnosing and evaluating severity of carpal tunnel syndrome



Pain and autonomic dysfunction are prominent symptoms in some patients with carpal tunnel syndrome (CTS). Infrared thermography (IRT) has been used to evaluate CTS by measuring the cutaneous temperature and sympathetic vasomotor function.


This study enrolled the 66 hands of 33 subjects, some of which had clinical CTS and the others were healthy. The enrolled patients completed the Boston Carpal Tunnel Questionnaire (BCTQ) and Historical-Objective scale, and underwent nerve conduction studies (NCSs) and IRT. Skin temperature was measured at the fingertips and the thenar and hypothenar regions in each hand. We analyzed (1) the correlations between self-reported severity, physician-assessed severity, and test results, and (2) the sensitivity and specificity of IRT in diagnosing CTS.


No significant correlation was observed between the results of the BCTQ, NCS, and IRT. IRT had a low sensitivity and high specificity in diagnosing CTS.


IRT cannot replace NCS in diagnosing CTS, nor did it provide an advantage in combination with NCS. However, lower temperatures at the median nerve in some hands with moderate-to-severe CTS suggested the involvement of sympathetic nerve fiber function. Follow-up studies with a larger-scale and complementary design are required to elucidate the relationships.


Carpal tunnel syndrome (CTS) is one of the most common entrapment neuropathies that clinical electrophysiologists encounter in their practices. Typical symptoms, signs, and findings of demyelination across the wrist in median nerve conduction studies (NCSs) have been the gold standard for diagnosing CTS,1 since NCSs have had high sensitivity and specificity (> 90%) in numerous studies. Nevertheless, reportedly 10-20% of patients with clinically defined CTS have false-negative NCS results.2 The clinical-electrophysiological discrepancy, which is the weak correlation between NCS findings and the severity of CTS symptoms, has also been widely discussed.3-5 The main limitation of NCS is that it examines only large myelinated Aβ-fibers, and not small myelinated Aδ-fibers or unmyelinated C fibers that mediate pain and paresthesia, which might explain this discrepancy.6 Infrared thermography (IRT) is a modality for measuring the sympathetic vasomotor nerve function that is mediated by small myelinated and unmyelinated nerve fibers, and it has been used in the fields of pain research and medicine.7 The present study evaluated whether IRT could be useful for diagnosing CTS as an ancillary method to NCS, especially in the presence of severe sensory symptoms and mild NCS abnormalities.



Patients with CTS who were admitted to the Neurology Outpatient Department of our hospital between March 2018 and January 2019 were recruited consecutively. Eligible patients were initially screened by one of the authors based on detailed history-taking and careful neurological examinations. The inclusion criteria were as follows: 1) the presence of numbness, tingling, or pain in at least two fingers from the thumb (digit 1 [D1]) to digit 4 (D4); 2) symptoms worsening at night (sleep) or during hand movements; 3) clumsiness, weakness, or muscle atrophy in the thenar region; 4) presence of unilateral hand symptom or much worse hand in bilateral symptomatic hands, 5) age > 20 years, and 6) symptoms lasting for > 2 months, even if they occurred intermittently. Provocative maneuvers (Tinel’s and Phalen’s signs) were recorded in all patients, but they were not required for a patient to be enrolled. The exclusion criteria were as follows: 1) the presence of a medical illness that can contribute to CTS (e.g., diabetes mellitus, thyroid disease, chronic liver or kidney disease, or alcohol abuse), 2) the presence of another peripheral nerve disorder (e.g., polyneuropathy, plexopathy, or radiculopathy), 3) previous injury or surgery of the symptomatic hand, 4) the presence of peripheral vascular disorders, or 5) pregnancy or breastfeeding. Written informed consent was obtained from all patients, and all of them underwent NCSs. The control group consisted of healthy subjects without evidence of clinical or electrophysiological CTS. Note that the hands of the enrolled patients that had never experienced any sensory problems and the hands with normal NCS results served as controls along with the included healthy subjects. This study was approved by the local ethics committee of our institution (approval no. GDIRB2017-360).

Assessment of clinical severity

All patients completed the following patient- and physician-based questionnaires to assess their clinical severity: the symptom severity scale (SSS) and functional status scale (FSS) of the Boston Carpal Tunnel Questionnaire8 and the Historical-Objective (Hi-Ob) scale9. The SSS and FSS consisted of 11 and 8 items, respectively, and were rated from 1 to 5 points, with higher scores indicating greater pain and disability. The SSS and FSS scores were calculated as the unweighted mean of all answered items for the corresponding scale; that is, the sum score for the responses divided by the number of items. The maximum and minimum scores on the SSS and FSS were 5 and 1, respectively. The Hi-Ob scale was assessed by the same trained neurologist. If the patients had bilateral CTS symptoms, they were instructed to complete questionnaires for each hand. Both the patient and the examining physician were blinded to the NCS results.


NCSs were performed using standard techniques of surface electrical stimulation and recording and an electromyography (EMG) system (Nicolet Synergy, Natus, Middleton, WI, USA). Skin temperature was maintained at above 31.0°C. Motor, sensory, and mixed NCSs of the bilateral median and ulnar nerves were performed to reveal the possibility of polyneuropathy and asymptomatic CTS. Needle EMG examinations were performed of the median nerve and the muscles innervated by the C6 and C7 roots, depending on patient tolerance. For the median motor NCS, compound muscle action potentials (CMAPs) were recorded in the abductor pollicis brevis muscle for stimulation at approximately 5 cm from the wrist. Normal values were defined as ≥ 5 mV for CMAP amplitude and ≤ 3.9 ms for distal motor latency (DML). For the median sensory NCS, sensory nerve action potentials (SNAPs) were recorded at the wrist with stimulation 1) at the palm (8-9 cm from the recording electrode) and 2) at the index finger using the orthodromic method. The sensory nerve conduction velocity (SNCV) was determined from the peak latency and calculated in meters per second. Normal values were defined as ≥ 10 μV for the SNAP amplitude, ≥ 34 m/s for the palm-wrist segment, and ≥ 40 m/s for the index finger-wrist segment. Electrophysiological CTS was diagnosed according to the guidelines of the American Association of Neuromuscular and Electrodiagnostic Medicine.10 Median-ulnar sensory conduction was compared between the wrist and the ring finger, and considered abnormal when the latency difference was ≥ 0.5 ms if conventional median sensory conduction was normal in both segments.11 The NCS results were graded according to the Padua scale for severity on each hand.12
Because the numbers of scores on the Hi-Ob and Padua scales differed and the group with moderate CTS was much larger than the other groups (Table 1), we categorized those scores into two and three groups, respectively: 1) the Hi-Ob scale was categorized into class 1 (stages 1 and 2) for paresthesia and class 2 (stages 3, 4, and 5) for objective sensory or motor deficits, and 2) the Padua scale was categorized into class 1 (grades 1 and 2), class 2 (grade 3), and class 3 (grades 4 and 5) depending on whether NCSs revealed abnormal SNCV only, abnormal DML, or abnormal SNAP and CMAP amplitudes, respectively.


The skin temperature of both hands was measured using a digital infrared thermographic imaging system (IRIS-XP, Medicore, Hanam, Korea) in an air-conditioned, window-less laboratory room that was maintained at 20-22°C and a humidity of 50-60%. The patients underwent IRT at least 24 hours after the NCS. They were prepared for IRT at 24 hours before the examination, with physical therapy, acupuncture, analgesics, and any topical agents affecting the skin not allowed during that time. On the day of the test, the patients were instructed to remove their top and remain in the room for 15 minutes to equilibrate. The temperatures at 14 sites (bilateral D1 to digit 5 [D5] and the bilateral thenar [Th] and hypothenar [Ht] regions) were measured as the regions of interest (ROIs) (Fig. 1). Because we included patients with bilateral CTS with a profoundly symptomatic single hand, we calculated the absolute temperature differences (ΔT-values) between each two of the seven sites in one hand rather than the thermal asymmetry between the left and right corresponding sites.
With reference to a previous study,13 we determined D1, D2, D3, and Th as the locations of median nerve vasomotor innervation, and D5 and Ht as the location of ulnar nerve vasomotor innervation. D4 was excluded from the analysis for clarity since both median and ulnar nerve innervated in D4. For sensitivity and specificity calculations, a significant difference was regarded as being due to the carpal tunnel lesion when one of ΔT(D1-D5), ΔT(D2-D5), ΔT (D3-D5), ΔT (Th-Ht) exceeded the reference value and simultaneously ΔT (D5-Ht) was below the reference value (0.4°C14, 0.6°C15, and 1.0°C16, respectively). The median index (MI) was calculated as (D1-D2) + (D2-D3) + (D1-D3),17 and the median-ulnar difference (MU) was calculated as (D1-D5) + (D2-D5) + (D3- D5) + (Th-Ht).18 Higher MI and MU values mean that the skin temperature in the median nerve distribution area is more variable, and this might reflect a malfunction in sympathetic vasoregulation.

Statistical analysis

Nonparametric tests were performed because Kolmogorov-Smirnov tests indicated that not all of the data conformed to a normal distribution. Continuous variables were examined using Mann-Whitney, Kruskal-Wallis, and univariate linear regression tests, as appropriate. p-values of less than 0.05 were considered to indicate statistical significance, and Bonferroni correction was applied for multiple comparisons. The sensitivity and specificity of NCSs, IRT, and their combination in diagnosing clinical CTS were calculated. Correlations between the SSS, FSS, Hi-Ob scale, Padua scale, and IRT results were examined using Spearman’s test. All statistical analyses were performed using Statistical Package for the Social Sciences (version 21.0, IBM Corp., Armonk, NY, USA).


Twenty-five patients with CTS and eight healthy control subjects were enrolled, and all of them underwent neurological examinations, NCSs, and IRT, and completed the study questionnaires (Table 1). The patients with CTS included 21 females (84%) and 5 patients with bilateral CTS symptoms (20%). Fifty hands of 25 patients with CTS were evaluated, among which 35 had clinical CTS and 40 had abnormal NCS results. It was particularly interesting that a discrepancy between the presence of symptoms and NCS results was observed in our data, as in previous studies: clinical CTS symptoms with normal NCS findings were observed in three hands, and NCS abnormalities without CTS symptoms were observed in eight hands. Patients with CTS tended to have a higher body mass index (BMI).


A side-to-side comparison of hand temperatures at the seven ROIs in eight healthy controls showed similarity and high correlation coefficients for each comparison, confirming the presence of symmetry in hand temperatures (Supplementary Table 1). When comparing healthy controls (n = 8) and patients with CTS who showed clinical symptoms in total agreement with NCS results (n = 14), absolute side-to-side differences in the D2 temperature tended to be greater in patients with CTS (mean value, 0.71°C vs. 0.26°C), though the difference did not reach statistical significance (p = 0.266) after adjusting for age, sex, and BMI. Considering all hands (n = 66), regardless of NCS results, comparisons of regional ΔT in the same hand between symptomatic CTS and healthy hands did not reveal any differences. However, regardless of symptoms, hands with abnormal NCS results showed higher MI than hands with normal NCS results (mean value, 0.86°C vs. 0.54°C), but this difference also did not reach statistical significance (p = 0.055) after adjusting for age, sex, and BMI (Supplementary Table 2).
Based on a pure clinical diagnosis of symptomatic and asymptomatic hands, the sensitivity of IRT decreased and its specificity increased as the cutoff value increased (Table 2). The sensitivity and specificity of IRT were not superior to those of NCS. Combining the existence of either IRT (cutoff value of 1.0°C) or NCS abnormalities resulted in a modest increase in the sensitivity from 91.4% to 94.3%.
Regarding the 32 hands with CTS symptoms and NCSproven CTS, ΔT (Th-Ht) tended to be higher for class 2 on the Hi-Ob scale (p = 0.085), while ΔT (D3-D5) tended to be higher for class 3 on the Padua scale (p = 0.106), which were considered more-advanced stages. Skin temperature was lower in hands with moderate-to-severe CTS than in hands with mild CTS (Fig. 2).

Correlations between BCTQ, NCS, and IRT

The SSS and FSS scores showed a strong mutual correlation (Spearman’s rho, 0.882; p < 0.001). However, they did not show a correlation with the Hi-Ob scale, Padua scale, and IRT parameters (ΔT between ROIs, MI, and MU) in 32 hands with CTS symptoms and NCS-proven CTS. The average SSS and FSS scores did not differ significantly with the classes on the Hi-Ob and Padua scales (Supplementary Fig. 1, 2). We further conducted a correlation analysis between SSS subscores concerning pain (items 1-5) and IRT parameters, which revealed no correlation. However, 11 hands with high SSS scores (> 4.0) showed a positive correlation with ΔT (Th-Ht) (Spearman’s rho = 0.812; p = 0.177) after adjusting for age, sex, and BMI, and hands with CTS with higher SSS scores tended to be colder in the thenar region (Fig. 3).
We reviewed 11 hands with a discrepancy between symptoms and NCS results. The mean SSS and FSS scores for hands with CTS symptoms (n = 3) were comparably high, at 3.18 and 2.75, respectively. The regional ΔT of the ROIs in 11 hands did not show abnormal differences in the territory of the median nerve. However, the reliability of the interpretation was limited by the small number of samples available for inclusion in the statistical analysis.


Standard symptoms of CTS include paresthesia, dull and aching discomfort, weakness or clumsiness, dry skin, swelling, and color changes in the hands.10 Autonomic dysfunction might be accompanied by CTS more often than currently thought. Verghese et al.19 reported the presence of autonomic dysfunction in more than half of CTS cases. Some patients with CTS suffer from prominent pain along with paresthesia and numbness, suggesting the involvement of nociceptive fiber dysfunction, and hence small myelinated and unmyelinated nerve fibers in the pathogenesis of CTS.20 Demyelination of large myelinated sensory nerve fibers occurs in the early stage of compressive neuropathy and causes tingling and numbness, which is why NCSs can detect CTS early and are widely used in clinical practice. Furthermore, small myelinated and unmyelinated A-δ and C fibers are affected in the advanced stages of compression. However, some studies have suggested that distal degeneration of small myelinated sensory nerves and the loss of intraepidermal nerves are already seen in mild CTS or the early phase of the disease.21 Sympathetic nerve fibers have the same distribution as motor and sensory branches of peripheral nerves, which encase them. Moreover, these fibers are more common in the nerves that supply the hand and foot.22
While NCS has been accepted as the gold standard for diagnosing CTS along with accurate clinical history-taking and examinations, it has inherent limitations in only evaluating the function of large myelinated fibers.6 This means that some patients with CTS exhibit normal NCS results, with Witt et al.2 reporting that this is the case in up to 25% of patients with CTS. This situation has resulted in some orthopedic surgeons considering NCSs unnecessary in patients with typical CTS.23 Several diagnostic tools are used to assess pain and small sensory nerve fiber function in CTS, including the sympathetic skin response, quantitative sensory testing, laser-evoked potentials, capillaroscopy, Doppler ultrasonography, skin biopsy, and IRT.17,20,24-28
An IRT device detects infrared light emitted from the body (i.e., body heat) using a camera and displays this on a screen. It provides information about changes in cutaneous blood flow, which is regulated by sympathetic vasomotor nerve fibers. The advantages of IRT are that it is noninvasive, painless, and rapid, and shows physiological changes. IRT has been used to diagnose pain, inflammation, and cancerous diseases.7 In the neurological field, some studies have used IRT for discriminating neuropathic pain, such as nerve root irritation and compression, peripheral nerve injury, and entrapment, from nonneuropathic pain. However, studies using IRT for diagnosing CTS have produced conflicting results, such as 1) high sensitivity and specificity24,29 or 2) low sensitivity and/or low specificity.17,30
In this study, the side-to-side temperature differences in D2 were higher in patients with CTS than in healthy controls, and the median nerve distribution had higher temperature variability than had the ulnar distribution in hands with CTS, although the statistical significance of the difference decreased after adjusting for covariates. However, IRT did not have a high sensitivity when applied alone (although it did have a high specificity), and did not show an advantage when combined with NCS. This means that IRT cannot be implemented in place of or in addition to NCS in diagnosing CTS, which conforms with the results of previous studies.17,30 One particularly interesting finding was that lower temperatures in D3 and Th were observed in hands with moderate-to-severe CTS on physical examination and hands with severe CTS symptoms, which suggested sympathetic vasomotor dysregulation in hands with more-severe CTS.
There are several ways to evaluate the severity of CTS, including self-administered questionnaires, physician-oriented clinical scales, the degree of demyelination, and secondary axonal loss in NCSs.8,9,12 All of these approaches have been well validated, but they cannot predict treatment outcomes, and no correlation has been observed between the findings of these tools.2,31 The present study found a significant correlation between the SSS and FSS and between the Hi-Ob and Padua scales, but no correlation was observed between the scores for the self-administered questionnaires (i.e., SSS, FSS) and the objective measurement scales (i.e., the Hi-Ob scale, Padua scale, and IRT parameters). These results suggest the need to develop other measurement tools that are strongly correlated with the objective status and evaluate the neuropathic pain aspect of CTS.
This study had several limitations. First, the numbers of enrolled patients and healthy controls were too small to obtain a high analytical power. Second, pain-specific questionnaires, such as the Neuropathic Pain Symptom Inventory or painDETECT, were not applied. Psychiatric surveys would help to quantify pain in patients with CTS. Third, including additional diagnostic tools to evaluate CTS would be better, especially regarding pain and small nerve fiber dysfunction. However, this study has strengths over previous studies in terms of focusing on the correlations between the symptom severity of patients, and objective examinations and diagnostic tests (NCS and IRT).
In conclusion, IRT is not advantageous over NCS in diagnosing and evaluating CTS. However, this study identified the presence of discrepancies between clinical diagnoses, subjective severity, and NCS results, and higher temperature variability in the median nerve distribution in hands with CTS with higher SSS scores and higher classes on the Hi-Ob scale. These observations mean that follow-up studies with a larger-scale and complementary design (e.g., selecting specific patient groups such as apparent painful clinical CTS with normal NCS findings) might be useful for clarifying whether IRT has practical usefulness in diagnosing CTS predominantly involving small sensory nerves, and in elucidating the associated relationships.

Supplementary Material

Supplementary Materials can be found with this article online

Supplementary Table 1.

A side-to-side comparison of the skin temperatures of hand region of interest in healthy controls

Supplementary Table 2.

Regional temperature difference within one hand according to the results of NCSs

Supplementary Fig. 1.

No differences of the mean and median value of the symptomatic severity scale (SSS) and function status scale (FSS) depending on historical-objective (Hi-Ob) class were observed.

Supplementary Fig. 2.

No differences of the mean and median value of the symptomatic severity scale (SSS) and function status scale (FSS) according Padua class were observed.


Conflicts of Interest

The authors declare no conflicts of interest relevant to this article.


This study was supported by the 2017 academic research funds of the Korean Society of Clinical Neurophysiology.


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Fig. 1.
An example of digital infrared thermographic imaging in a patient with carpal tunnel syndrome. Regions of interest are indicated as squares where the temperature was measured.
Fig. 2.
(A) The mean and median values of the absolute temperature difference (ΔT) between the thenar (Th) and hypothenar (Ht) regions in the same hand with carpal tunnel syndrome (CTS) were higher for class 2 on the historical-objective (Hi-Ob) scale. (B) The temperature was lower in Th (median nerve distribution) in hands with more-severe CTS. (C) The mean and median values of ΔT between digit 3 (D3) and digit 5 in the same hand with CTS were higher for class 3 on the Padua scale. (D) The temperature was lower for D3 (median nerve distribution) in hands with more-severe CTS.
Fig. 3.
(A) A positive correlation was observed between ΔT for the thenar (Th) and hypothenar (Ht) regions and the symptomatic severity score (of > 4.0) in a hand with carpal tunnel syndrome (CTS). (B) The temperature was lower in Th (median nerve distribution) in hands with CTS with higher symptomatic severity score (SSS).
Table 1.
Clinical data of the enrolled patients with CTS and healthy controls
Patients with CTS (25 patients, 50 hands) Healthy controls (8 subjects, 16 hands)
Age (years) 54.2 ± 12.9 (27-78) 38.8 ± 9.05 (27-52)
Sex (female) 21 (84) 4 (50)
Body mass index (kg/m2) 25.3 ± 3.7 (19.2-35.6) 20.4 ± 3.3 (16.6-25.1)
Clinically affected hand 35
 Right (unilateral) 17 (34)
 Left (unilateral) 8 (16)
 Bilateral 5 (20)
Clinically unaffected hand 15
Abnormal NCS handa 40
 Right (unilateral) 8 (16)
 Left (unilateral) 2 (4)
 Bilateral 15 (60)
Normal NCS hand 10
Symptom duration (months) 16.9 ± 20.0 (2-60)
BCTQ-SSS (in symptomatic hands) 2.98 ± 1.16 (1.27-4.73)
BCTQ-FSS (in symptomatic hands) 2.21 ± 0.94 (1.0-4.63)
Hi-Ob scale Among clinically affected 35 hands
 Stage 1 6 (17)
 Stage 2 14 (40)
 Stage 3 7 (20)
 Stage 4 8 (23)
 Stage 5 0
Padua’s scale Among abnormal NCS 40 hands
 Grade 1 3 (7.5)
 Grade 2 8 (20.0)
 Grade 3 21 (52.5)
 Grade 4 1 (2.5)
 Grade 5 7 (17.5)

Values are presented as mean ± standard deviation (range) or number (%).

CTS, carpal tunnel syndrome; NCS, nerve conduction study; BCTQ, Boston Carpal Tunnel Questionnaire; SSS, symptomatic severity scale; FSS, function status scale; Hi-Ob scale, historical-objective scale.

a Abnormal NCS results, regardless of symptoms.

Table 2.
Sensitivity and specificity of thermography and NCS
Sensitivity Specificity
Regarding 39 hands with consistent symptoms (CTS or normal) and NCS
 0.4°C 13/32 (40.6) 2/7 (71.4)
 0.6°C 6/32 (18.8) 1/7 (85.7)
 1.0°C 4/32 (12.5) 1/7 (85.7)
Based on a pure clinical diagnosis of CTS in 50 hands
 Only NCS 32/35 (91.4) 8/15 (46.6)
 NCS or 0.4°C 33/35 (94.3) 10/15 (33.3)
 NCS or 0.6°C 33/35 (94.3) 9/15 (40.0)
 NCS or 1.0°C 33/35 (94.3) 8/15 (46.6)

Values are presented as number (%).

NCS, nerve conduction study; CTS, carpal tunnel syndrome.

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