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Dear Sir,
we appreciated the paper of Rosenberg et al.1 entitled: “Management of hepatic artery aneurysm: a case series”.
The authors have described a series of four Hepatic Artery Aneurysm (HAA) cases that were all diagnosed by Multi-Detector Computed Tomography (MD-CT). One patient was treated by endovascular stenting, the other was candidate to follow-up and the last two treated by surgery techniques.
HAA is a rare disease, but can result fatal if it is ruptured.1-3 We agree with the use of MD-CT as “gold standard” diagnostic imaging in detecting HAA and for capable of treatment planning.1,4 Treatment of HAA is indicate in case of: clinical symptoms (pain, distal embolization, rupture), twice the diameter of the hepatic artery or more than 2 cm increased in diameter, and in pregnant women.1-3 Invasive treatment for HAA can be surgical or endovascular. Endovascular approaches in HAA, compare to conventional abdominal surgery, benefit in less invasive treatments.2 Aim of our editorial is to emphasize the three possible endovascular therapeutic techniques in HAA (common and proper hepatic artery segments - ruptured and unruptured): i) packing embolization, ii) isolation embolization and iii) stenting deployment.
i) Packing embolization technique (or direct embolization technique) is characterized by coil or liquid agent device filling of the aneurysm sac.4 To guarantee patency of the hepatic artery segment and to prevent possible coil migration out of the aneurysm’s sac it is possible to place a bare stent into the artery segment (stent assisted technique).5 However, this technique provides a limit in subsequent imaging follow-up, mainly with MD-CT. On MD-CT especially coils or high-density liquid embolic devices create artefacts, which may not highlight a possible endoleak at the level of the treated HAA (Fig. 1). In these cases colour-Doppler ultrasound, contrast-enhanced ultrasound, or angiography are used to follow-up treated aneurysm over time.
ii) Isolation embolization technique (or sandwich technique) is characterized by the complete embolization of all outflow (distal) and inflow (proximal) arteries of the aneurysm sac by coil and/or plug devices.1,4 This technique is not always feasible on anatomical variants of collateral vessels. However, when performed, in the subsequent MD-CT follow-up there are present only few artefacts are present that allow evaluating aneurysm thrombosis or endoleak (Fig. 2). Isolation embolization technique is equivalent to surgical exclusion ligation. The main disadvantage of this technique is that it does not preserve the patency of the treated artery segment. There is a very low risk of possible ischemic lesion of the liver due to its dual vascularization (portal vein approximately 70% and hepatic artery 30% of liver blood flow) and an artery vascular compensation over time by collateral vessels.2-4
iii) Stenting deployment technique, using covered or flow-diverter devices, has the aim of guarantee aneurysm exclusion and to ensure blood perfusion to distal hepatic branch vessels. This type of endovascular approach is often limited by aneurysm location (need for distal and proximal neck) and arterial anatomy (tortuosity that can limit the navigability of rigid and large-calibre stents) (Fig. 3). Flow-diverter stents may be possible to maintain patency of collateral vessel of the aneurysm by modulating intra-sac blood flow;2,3 but they are not indicated in pseudo or ruptured HAAs. In conclusion, in patients affected by HAA an appropriate multidisciplinary discussion focusing attention on aneurysm anatomical location, characteristics, extension, hemodynamic status, patient age and comorbidities are necessary to determine the specific treatment for each individual case.
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