In this issue of Korean Circulation Journal, Yoon et al.5) present valuable data regarding exercise-induced cardiac remodeling in 1,185 highly trained university athletes. This study highlights sex differences in cardiac remodeling in athletes, and also shows what is in common regardless of sex. The main sex difference that the authors emphasize is that male athletes have more remodeling of the left chambers, and female athletes have more remodeling of the right ventricle (RV).5) The common points are that exercise-induced cardiac remodeling in any cardiac chamber was common regardless of sex, and remodeling of the left ventricle (LV), left atrium (LA), or RV does not overlap in many cases.5) Such results cannot be explained clearly through the well-known pathophysiology of athletes' hearts but such data need to be analyzed with interest. Previous studies published by the same research group have shown that female athletes had less LV volume and mass, higher LV ejection fraction, higher absolute value for LV global longitudinal strain, and less LA enlargement than male athletes.2)6)7) The present study adds information about RV remodeling to the analysis of previous studies and focuses more on sex differences.

Despite interesting findings that showed RV remodeling happens more often in female athletes, we need to think carefully before accepting these new results. First, absolute values for RV size were larger in male than female athletes, however, the body surface area (BSA)-indexed RV dimensions were greater in female athletes.5) Likewise, when we look at the LA and LV sizes as a dimension, the absolute values are also larger in male than female athletes, but the BSA-indexed LA and LV dimensions are greater in female athletes. The reason why RV remodeling was more common in female athletes was the RV dimensions were calculated and then indexed with BSA. Moreover, if the RV volume is calculated by three-dimensional echocardiography or cardiac magnetic resonance imaging and corrected by BSA, the key findings of this study are likely to reverse. Second, the racial distribution of athletes participating in this study was 40.9% Caucasian, 23.7% Asian, and 11.9% African as described in a previous report.2) As this study group reported that LV remodeling was frequent in individuals of African descent, there is a possibility that ethnic differences as well as sex differences exist in RV remodeling.

The results of this study give and motivate a future perspective on athlete hearts. Recently, interest in RV remodeling in athletes and differentiation of physiologic RV remodeling from arrhythmogenic cardiomyopathy has increased because intense exercise might induce RV inflammation and fibrosis.1)8)9)10) Also, it seems to be important to investigate pulmonary artery remodeling and exercise-induced pulmonary hypertension in athletes since an abnormal increase in pulmonary artery systolic pressure can lead to RV dilatation and dysfunction. Therefore, in the future, RV volumetric assessment, myocardial tissue characterization, evaluation of the pulmonary artery, and RV-pulmonary artery coupling by multimodality imaging may clarify sex differences in RV remodeling in athletes and the clinical implications associated with this remodeling.