Journal List > J Korean Ophthalmol Soc > v.61(3) > 1144110

Lee, Yoon, and Chung: Acute Leukemia Relapse Presenting as Recurrent Involvement of the Optic Nerve

Abstract

Purpose

To report two cases with recurrent involvement of the optic nerve as the initial sign of acute leukemic relapse.

Case summary

An 8-year-old male with acute lymphoblastic leukemia on the maintenance chemotherapy was referred for a decrease in visual acuity in the right eye. The visual acuity and optic disc swelling were completely resolved with high-dose steroid therapy. Two months after the initial presentation, the symptoms recurred and brain/orbit magnetic resonance imaging (MRI) showed high intensity along the right optic nerve from the retrobulbar area to the optic chiasm. The visual acuity was restored after high-dose steroid therapy. One month after the second attack, the symptoms recurred and the cerebrospinal fluid cytology was positive for lymphoblasts. Three weeks after the intrathecal chemotherapy, the visual acuity improved fully, but optic disc atrophy developed. A 45-year-old male, who received allogenic peripheral blood stem cell transplantation for acute myeloid leukemia, presented with a decrease in visual acuity in the left eye. The left optic disc swelling improved with high-dose steroid therapy, but the medication was restarted due to the recurrence of symptoms 3 weeks later. Brain MRI showed a mass lesion com-pressing the left optic nerve, presumed to be a myeloid sarcoma. One month after local irradiation, the visual acuity was no light perception in the left eye.

Conclusions

In patients with a prior history of acute leukemia, the recurrent involvement of the optic nerve should be considered as a central nerve system relapse, regardless of improvement with steroid treatment.

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Figure 1.
Ocular findings including fundus photography and optical coherence tomography (OCT) and orbit/brain magnetic resonance imaging (MRI) showing involvement of the right optic nerve for case 1. (A) Fundus photographs and OCT at the initial presentation show a severe disc swelling with peripapillary retinal hemorrhage in the right eye. (B) Two months after the initial presentation, fundus photographs show a mild disc swelling in the right eye, but axial T2-weighted orbit and coronal T2-weighted brain MRI show high intensity from intraorbital portion to optic chiasm in the right optic nerve (yellow arrows). (C) Three and half months after the initial presentation, fundus photographs show a moderate disc swelling and vessel tortuosity in the right eye and orbit/brain MRI shows high intensity in the right optic nerve, more prominent compared with (B) (yellow arrows). (D) Three weeks after chemotherapy, fundus photographs and OCT show restoration of disc swelling and vessel tortuosity in the right eye. (E) A year after the initial presentation, fundus photographs and OCT show a mild thinning of peripapillary retinal nerve fiber layer in the right eye. OD = oculus dexter; OS = oculus sinister.
jkos-61-319f1.tif
Figure 2.
Histologic findings of cerebrospinal fluid (CSF) cytology for case 1. (A, B) Heavy infiltration of neoplastic lymphoblasts (CSF smear Wright-Giemsa stain ×400, ×1,000). (C) Positive staining for lymphoid differentiation (CSF smear Papanicolau stain, ×400).
jkos-61-319f2.tif
Figure 3.
Ocular findings including fundus photography, optical coherence tomography (OCT), and Humphrey 24–2 visual field test, and brain magnetic resonance imaging (MRI) showing involvement of the left optic nerve for case 2. (A) Fundus photographs and OCT at the initial presentation show a moderate disc swelling in the left eye. The haziness of fundus photographs is attributed to posterior subcapsular opacity in both eyes. Visual field examination demonstrates general depression in the left eye. (B) Three weeks after the initial presentation, fundus photographs and OCT show a mild disc swelling in the left eye. (C) Three weeks after the initial presentation, coronal T2-weighted brain MRI shows high intensity along the left retrobulbar optic nerve and mass lesion in the cistern segment of the left optic nerve (yellow arrows). (D) Four months after the initial presentation, fundus photographs and OCT show optic atrophy in the left eye. OD = oculus dexter; OS = oculus sinister.
jkos-61-319f3.tif
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