Recent Advances in the Pathogenesis and Treatment of Functional Dyspepsia with Focus on the Duodenum

Ra Ri Cha; Hyun Jin Kim

doi:10.4166/kjg.2020.75.2.112

Journal List > Korean J Gastroenterol > v.75(2) > 1143089

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Cha and Kim: Recent Advances in the Pathogenesis and Treatment of Functional Dyspepsia with Focus on the Duodenum

Research Update

Korean J Gastroenterol 2020;75(2):112-114.

Published online: 4 October 2020

DOI: https://doi.org/10.4166/kjg.2020.75.2.112

Recent Advances in the Pathogenesis and Treatment of Functional Dyspepsia with Focus on the Duodenum

Ra Ri Cha, Hyun Jin Kim

Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Korea

Correspondence to: Hyun Jin Kim, Department of Internal Medicine, Gyeongsang National University Changwon Hospital, 11 Samjeongja-ro, Seongsan-gu, Changwon 51472, Korea. Tel: +82-55-214-3710, Fax: +82-55-214-3250, E-mail: imdrkim@naver.com, ORCID: https://orcid.org/0000-0003-3853-0229

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Article

Novel Concepts in the Pathophysiology and Treatment of Functional Dyspepsia (Gut 2019 Nov 29. [Epub ahead of print])

References

1. Vanheel H, Carbone F, Valvekens L, et al. Pathophysiological abnormalities in functional dyspepsia subgroups according to the Rome III criteria. Am J Gastroenterol. 2017; 112:132–140.

2. Walker MM, Talley NJ. The role of duodenal inflammation in functional dyspepsia. J Clin Gastroenterol. 2017; 51:12–18.

3. van Baar ACG, Nieuwdorp M, Holleman F, Soeters MR, Groen AK, Bergman JJGHM. The duodenum harbors a broad untapped therapeutic potential. Gastroenterology. 2018; 154:773–777.

4. Camilleri M. Gastrointestinal hormones and regulation of gastric emptying. Curr Opin Endocrinol Diabetes Obes. 2019; 26:3–10.

5. Jung HK, Talley NJ. Role of the duodenum in the pathogenesis of functional dyspepsia: a paradigm shift. J Neurogastroenterol Motil. 2018; 24:345–354.

6. Lee KJ, Kim JH, Cho SW. Dyspeptic symptoms associated with hypersensitivity to gastric distension induced by duodenal acidification. J Gastroenterol Hepatol. 2006; 21:515–520.

7. Lee KJ, Demarchi B, Demedts I, Sifrim D, Raeymaekers P, Tack J. A pilot study on duodenal acid exposure and its relationship to symptoms in functional dyspepsia with prominent nausea. Am J Gastroenterol. 2004; 99:1765–1773.

8. Bratten J, Jones MP. Prolonged recording of duodenal acid exposure in patients with functional dyspepsia and controls using a radiotelemetry pH monitoring system. J Clin Gastroenterol. 2009; 43:527–533.

9. Vanheel H, Farré R. Changes in gastrointestinal tract function and structure in functional dyspepsia. Nat Rev Gastroenterol Hepatol. 2013; 10:142–149.

10. Fried M, Feinle C. The role of fat and cholecystokinin in functional dyspepsia. Gut. 2002; 51(Suppl 1):i54–i57.

11. Simrén M, Vos R, Janssens J, Tack J. Acid infusion enhances duodenal mechanosensitivity in healthy subjects. Am J Physiol Gastrointest Liver Physiol. 2003; 285:G309–G315.

12. Vanuytsel T, Karamanolis G, Van Oudenhove L, Vos R, Tack J. Influence of ondansetron on gastric sensorimotor responses to short duodenal acid infusion in healthy volunteers. Neurogastroenterol Motil. 2011; 23:226–232. e115.

13. Talley NJ, Ford AC. Functional dyspepsia. N Engl J Med. 2016; 374:896.

14. Moayyedi P, Lacy BE, Andrews CN, Enns RA, Howden CW, Vakil N. ACG and CAG clinical guideline: management of dyspepsia. Am J Gastroenterol. 2017; 112:988–1013.

15. Jackson MA, Goodrich JK, Maxan ME, et al. Proton pump inhibitors alter the composition of the gut microbiota. Gut. 2016; 65:749–756.

16. Imhann F, Bonder MJ, Vich Vila A, et al. Proton pump inhibitors affect the gut microbiome. Gut. 2016; 65:740–748.

17. Friesen CA, Neilan NA, Schurman JV, Taylor DL, Kearns GL, Abdel-Rahman SM. Montelukast in the treatment of duodenal eosinophilia in children with dyspepsia: effect on eosinophil density and activation in relation to pharmacokinetics. BMC Gastroenterol. 2009; 9:32.

18. Jung HK, Keum BR, Jo YJ, et al. Diagnosis of functional dyspepsia: a systematic review. Korean J Gastroenterol. 2010; 55:296–307.

19. Darkoh C, Lichtenberger LM, Ajami N, Dial EJ, Jiang ZD, DuPont HL. Bile acids improve the antimicrobial effect of rifaximin. Antimicrob Agents Chemother. 2010; 54:3618–3624.

TOOLS

ORCID iDs: Hyun Jin Kim
https://orcid.org/0000-0003-3853-0229
Similar articles