Journal List > J Korean Soc Radiol > v.81(1) > 1141989

Gu, Yi, Kim, Lee, Kang, and Ji: Comparative Analysis of Image Quality and Adverse Events between Iopamidol 250 and Ioversol 320 in Hepatic Angiography for Transcatheter Arterial Chemoembolization

Abstract

Purpose

This study aimed to compare the image quality and adverse events between Iopamidol 250 and Ioversol 320 usage during transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).

Materials and Methods

Medical records and hepatic angiography from 113 patients who un-derwent TACE with Iopamidol 250 (44 patients) and Ioversol 320 (69 patients) were retrospective-ly reviewed. Vessel perception on hepatic angiography was graded into three categories by two radiologists for hepatic subsegmental arteries, the right gastroepiploic artery, right gastric artery, and pancreaticoduodenal artery. Imaging concordance was assessed by comparing the number of detected HCCs on hepatic angiography and CT. The adverse events before and after hepatic angiography were evaluated.

Results

The mean vessel perception scores were 2.92 and 2.94 for Iopamidol 250 and Ioversol 320, respectively. The imaging concordance was 31 (70.5%) and 46 (66.7%) patients for Iopamidol 250 and Ioversol 320, respectively. There were no statistical differences in vessel perception or imaging concordance (p > 0.05). One and six patients experienced nausea for Iopamidol 250 and Ioversol 320, respectively. There was no statistical difference in adverse events (p = 0.24).

Conclusion

Iopamidol 250 can be used in hepatic angiography for TACE without significant difference in image quality or occurrence of adverse events from Ioversol 320.

Index terms

Contrast Media, Angiography, Tomography, X-Ray Computed, Chemoembolization, Therapeutic

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Fig. 1.
A 62-year-old male with HCC who was administered Iopamidol 250. A. Digital subtraction hepatic angiography shows clearly visible RGEA and PDA (score 3), poorly visible HSSA (score 2), and invisible RGA (score 1). B. An HCC (arrow) is noted in the right hepatic lobe. C. Coronal reconstruction CT scan from the arterial phase shows the HCC (arrow) in the liver S8. The concordance rate is 1. HCC = hepatocellular carcinoma, HSSA = hepatic subsegmental arteries, PDA = pancreaticoduodenal artery, RGA = right gastric artery, RGEA = right gastroepiploic artery
jksr-81-166f1.tif
Table 1.
Comparison of Vessel Perception Scores between Iopamidol 250 and Ioversol 320
  Iopamidol 250 (n = 44) Ioversol 320 (n = 69) p-Value
Mean Scores SD Mean Scores SD
Observer A          
 HSSA 2.91 0.29 2.97 0.17 0.241
 RGEA 2.95 0.30 2.94 0.34 0.771
 RGA 2.89 0.39 2.96 0.21 0.317
 PDA 2.98 0.15 2.96 0.21 0.497
Observer B          
 HSSA 2.89 0.32 2.97 0.17 0.134
 RGEA 2.91 0.36 2.80 0.53 0.133
 RGA 2.84 0.48 2.97 0.17 0.101
 PDA 2.98 0.15 2.93 0.31 0.226
Mean 2.92 0.32 2.94 0.29 0.276

Vessel perception scores for each vessel: 1 = invisible vessel as non-evaluable quality, 2 = visible vessel without clarity, 3 = visible vessel with clarity.

HSSA = hepatic subsegmental arteries, PDA = pancreaticoduodenal artery, RGA = right gastric artery, RGEA = right gastroepiploic artery, SD = standard deviation

Table 2.
Comparison of Imaging Concordance Rates between Iopamidol 250 and Ioversol 320 for Tumor De-tection Number on Hepatic Angiography and CT
Rates Iopamidol 250 (n = 44, %) Ioversol 320 (n = 69, %)
0 7 (15.9) 14 (20.3)
1 31 (70.5) 46 (66.7)
12 31 (70.5) 6 (13.6) 46 (66.7) 9 (13.0)

Comparison of the number of hepatocellular carcinomas on hepatic angiography and CT: 0 = more on CT, 1 = equal on CT and angiography, 2 = more on hepatic angiography.

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