A case of IgG4-related disease associated with psoriasis-like skin rash and hypereosinophilic syndrome

Han-Ki Park; Man Hoon Han; Sang Jin Lee

doi:10.4168/aard.2020.8.1.45

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Park, Han, and Lee: A case of IgG4-related disease associated with psoriasis-like skin rash and hypereosinophilic syndrome

Case Report

Allergy, Asthma & Respiratory Disease 2020; 8(1): 45-49.

Published online: 31 January 2020

DOI: https://doi.org/10.4168/aard.2020.8.1.45

A case of IgG4-related disease associated with psoriasis-like skin rash and hypereosinophilic syndrome

Han-Ki Park¹, Man Hoon Han², Sang Jin Lee¹

¹Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Korea.

²Department of Pathology, School of Medicine, Kyungpook National University, Daegu, Korea.

Correspondence to: Sang Jin Lee. Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, 807 Hoguk-ro, Buk-gu, Daegu 41404, Korea. Tel: +82-53-200-2617, Fax: +82-53-200-2029, dream1331@naver.com

Received 29 July 2019 Revised 27 August 2019 Accepted 27 August 2019

The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/).

Abstract

Immunoglobulin (Ig) G4-related disease (IgG4-RD) is newly recognized immune-mediated and fibroinflammatory conditions with various organ involvements. Any organs can be involved, but the pancreas, salivary gland, lymph nodes, and orbit are known to be commonly involved organs. A 54-year-old man presented with complaint of psoriasis like skin rash developed 4 years prior to admission. Although he had been treated for skin rash, the extent of skin lesions increased as well as hypereosinophilia, and multiple lymphadenopathies were newly developed. The patient was diagnosed with IgG4-RD by serum IgG4 levels and histologic examination of the inguinal lymph node. One month after treatment with steroid and azathioprine, his skin rash and lymphadenopathies resolved with improvement and eosinophil count was within the normal range. We herein report a case of a IgG4-RD patient associated with psoriasis-like skin rash and hypereosinophilic syndrome.

Keywords: IgG4-related disease, Psoriasis, Hypereosinophilic syndrome

Figures and Tables

Fig. 1

Skin lesion of IgG4-related disease patient.

Fig. 2

Pathology of skin lesion. H&E staining (A, ×100; B, ×200), parakeratosis (yellow arrow), Munro's abscess (red arrow).

Fig. 3

Pathology of inguinal lymph node. (A) CD138 (plasma cell) staining (A, ×40; B, ×200), (C) IgG staining (×400), and (D) IgG4 staining (×400).

Fig. 4

Skin lesion of IgG4-related disease patient after treatment.

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ORCID iDs: Sang Jin Lee
https://orcid.org/0000-0002-7892-6482
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