PDF
ePub
Citation
Print
Abstract
Policosanol extracted from sugarcane wax is a generic term used for total fatty alcohols obtained from esterification of fatty acids. It has been approved as a health functional food by the Ministry of Food and Drug Safety of Korea in 2006. Policosanol is well-known to aid in lowering blood cholesterol level. Recently, several studies have reported the physiological activities of policosanol, such as anti-inflammatory effects, antioxidant effects, and lowering of the incidence of ageing-related diseases, for example, hypertension, stroke, among others. This review describes the physiological activities of policosanol and its applications in the field of health functional foods.
REFERENCES
1.Marinangeli C. P.., Kassis A. N.., Jain D.., Ebine N.., Cunnane S. C.., Jones P. J. Br. J.Nutr. 2007. 97:381–388.
2.Committee for the Korean Guidelines for the Management of Dyslipidemia. Korean Circ. J. 2016. 46:275–306.
3.Marinangeli C. P.., Jones P. J.., Kassis A. N.., Eskin M. N.Crit. Rev. Food Sci. Nutr. 2010. 50:259–267.
4.Liao F.., Chen W.Hubei Agric. Sci. 2013. 52:1125–1127.
5.Singh D. K.., Li L.., Porter T. D. J.Pharmacol. Exp. Ther. 2006. 318:1020–1026.
7.Menendez R.., Amor A. M.., Gonzalez R. M.., Fraga V.., Mas R.Biol. Res. 1996. 29:253–257.
8.Menéndez R.., Arruzazabala L.., Más R.., Del Rio A.., Amor A. M.., González R. M.., Carbajal D.., Fraga V.., Molina V.., Illnait J. Br. J.Nutr. 1997. 77:923–932.
9.Arruzazabala M.L.; Carbajal, D.; Mas, R.; Molina, V.; Valdes, S.; Laguna, A., Biol. Res. 1994. 27:205–208.
10.Arruzazabala M. L.., Carbajal D.., Mas R.., Castano G.., Sotolongo R.., Mesa R.Rev. CENIC Cien. Biol. 1991. 22:60–61.
11.Rodriguez-Echenique C.., Mesa R.., Mas R.., Noa M.., Menendez R.., Gonzalez R. M.., Amor A. M.., Fraga V.., Sotolongo V.., Laguna A.Food Chem. Toxicol. 1994. 32:565–575.
12.Hernandez F.., Illnait J.., Mas R.., Castano G.., Fernández L.., Gonzalez M.., Cordovi N.., Fernandez J. C.Curr. Ther. Res. Clin. Exp. 1992. 51:568–575.
13.Castano G.., Mas R.., Fernandez J.., Lopez E.., Illnait J.., Fernandez L.., Mesa M.Curr. Ther. Res. Clin. Exp. 2003. 64:522–537.
14.Lopez E.., Illnait J.., Fernandez J. C.., Fernandez L.., Gamez R.., Mesa M.., Mendoza S.., Mas R.., Ruiz D.., Jardines Y.Rev. CRNIC Cien. Biol. 2010. 41:31–37.
15.Castano G.., Mas R.., Fernandez L.., Illnait J.., Hernandez E.., Fernandez J.., Gamez R.., Gutierrez C.., Alvarez E.Curr. Ther. Res. 2002. 63:286–303.
16.Illnait J.., López E.., Fernández L.., Mas R.., Gamez R.., Mesa M.., Mendoza S.., Fernández J. C.Int. J. Pharm. Sci. Rev. Res. 2013. 22:303–309.
17.Lin Y.., Rudrum M.., van der Wielen R. P.., Trautwein E. A.., McNeill G.., Sierksma A.., Meijer G. W.Metabolism. 2004. 53:1309–1314.
18.Gouni-Berthold I.., Berthold H. K.Am. Heart J. 2002. 143:356–365.
19.Tang M.., Wu S. Z.., Gong X.Zhonghua Xin Xue Guan Bing Za Zhi. 2013. 41:488–492.
20.Wang H. Y.., Jiao Q. P.., Chen S. Y.., Sheng J.., Jiang H.., Lu J.., Zheng S. B.., Fang N. Y. Am. J.Med. Sci. 2018. 356:254–261.
21.Careskey H. E.., Davis R. A.., Alborn W. E.., Troutt J. S.., Cao G.., Konrad R. J. J.Lipid Res. 2008. 49:394–398.
22.Welder G.., Zineh I.., Pacanowski M. A.., Troutt J. S.., Cao G.., Konrad R. J. J.Lipid Res. 2010. 51:2714–2721.
23.Mousavi S. A.., Berge K. E.., Leren T. P. J.Intern. Med. 2009. 266:507–519.
24.Guo Y. L.., Xu R. X.., Zhu C. G.., Wu N. Q.., Cui Z. P.., Li J. J.Evid. Based Complement. Alternat. Med. 2014. 2014:926087.
25.Lee H. Y. J.Korean Med. Assoc. 2018. 6:485–492.
26.Kim S. J.., Yadav D.., Park H. J.., Kim J. R.., Cho K. H.Front. Physiol. 2018. 9:412.
27.Cho K. H.., Kim S. J.., Yadav D.., Kim J. Y.., Kim J. R.Oxid. Med. Cell. Longev. 2018. 2018:4809525.
28.Fraga V.., Menendez R.., Amor A. M.., Gonzalez R. M.., Jimenez S.., Mas R.Arch. Med. Res. 1997. 28:355–360.
29.Ng C. H.., Leung K. Y.., Huang Y.., Chen Z. Y. J.Agric. Food Chem. 2005. 53:6289–6293.
30.Cicero A. F.., Colletti A.Phytomedicine. 2016. 23:1113–1118.
31.Castano G.., Menendez R.., Mas R.., Amor A.., Fernandez J. L.., Gonzalez R. L.., Lezcay M.., Alvarez E.Int. J. Clin. Pharmacol. Res. 2002. 22:89–99.
32.Harrabi S.., Ferchichi A.., Bacheli A.., Fellah H.Lipids Health Dis. 2018. 17:82.
33.Castano G.., Fernandez L.., Mas R.., Illnait J.., Mesa M.., Fernandez J. C.Clin. Drug Investig. 2003. 23:639–650.
34.Elseweidy M. M.., Zein N.., Aldhamy S. E.., Elsawy M. M.., Saeid S. A.Exp. Biol. Med. 2016. 241:1943–1949.
35.Kaup R. M.., Khayyal M. T.., Verspohl E. J.Phytother. Res. 2013. 27:264–271.
36.Elseweidy M. M.., Mohamed H. E.., Elrashidy R. A.., Atteia H. H.., Elnagar G. M. J.Cardiovasc. Pharmacol. Ther. 2018. 23:551–560.
37.Noa M.., Mas R.., de la Rosa M. C.., Magraner J. J.Pharm. Pharmacol. 1995. 47:289–291.
38.Carbajal D.., Arruzazabala M. L.., Valdes S.., Mas R.Prostaglandins, Leukot. Essent. Fatty Acids. 1998. 58:61–64.
39.Arruzazabala M. L.., Mas R.., Molina V.., Carbajal D.., Mendoza S.., Fernandez L.., Valdes S.Int. J. Tissue React. 1998. 20:119–124.
40.Wong W. T.., Ismail M.., Tohit E. R.., Abdullah R.., Zhang Y. D.Evid. Based Complement. Alternat. Med. 2016. 2016:7343942.
41.Wong W. T.., Ismail M.., Imam M. U.., Zhang Y. D.BMC Complement. Altern. Med. 2016. 16:252.
42.Illnait J.., Castano G.., Alvarez E.., Fernandez L.., Mas R.., Mendoza S.., Gamez R.Angiology. 2008. 59:269–277.
43.Molina V.., Ravelo Y.., Noa M.., Mas R.., Perez Y.., Oyarzabal A.., Mendoza N.., Valle M.., Jimenez S.., Sanchez J.Indian J. Pharm. Sci. 2013. 75:635–641.
44.Ortega L. L.., Sanchez J.., Mas R.., Fernandez L.., Mendoza S.., Gamez R.., Fernandez J. C.., Illnait J.., Alvarez E. J.Med. Food. 2006. 9:378–385.
45.Sánchez J.., Fernández, L. Illnait J.., de Lourdes Arruzazabala M.., Molina V.., Mas R.., Mendoza, S. Carbajal, D. Mesa M.., Fernández J.IOSR J. Pharm. 2012. 2:14–24.
46.Sanchez J.., Illnait J.., Mas R.., Mendoza S.., Fernandez L.., Mesa M.., Vega H.., Fernandez J.., Reyes P.., Ruiz D.Rev. Neurol. 2017. 64:153–161.
47.Sánchez J.., Illnait J.., Mas R.., Mendoza S.., Vega H.., Fernández L.., Mesa M.., Fernández J.., Reyes P.., Ruiz D.Int. J. Pharm. Sci. Rev. Res. 2016. 37:7–14.
48.Sanchez J.., Illnait J.., Mas R.., Perez Y.., Mendoza S.., Cabrera L.., Fernandez L.., Mesa M.., Fernandez J.., Oyarzabal A.., Molona V.., Reyes P.IOSR J. Pham. 2013. 3:31–40.
49.Sanchez-Lopez J.., Fernandez-Travieso J. C.., Illnait-Ferrer J.., Fernandez-Dorta L.., Mendoza-Castano S.., Mas-Ferreiro R.., Mesa-Angarica M.., Reyes-Suarez P.Rev. de Neuro. 2018. 67:331–338.
50.Lee E. Y.., Yoo J. A.., Lim S. M.., Cho K. H.Rejuvenation Res. 2016. 19:149–158.
51.Lim S. M.., Yoo J. A.., Lee E. Y.., Cho K. H.Rejuvenation Res. 2016. 19:59–70.
52.Lee J. H.., Jia Y.., Thach T. T.., Han Y.., Kim B.., Wu C.., Kim Y.., Seo W. D.., Lee S. J.Nutr. Res. 2017. 43:89–99.
53.Lim D.., Ha M.., Song I. J.Korean Med. Sci. 2014. 29:1597–1603.
Table 1.
Summary of policosanol's physiological activities
XML Download