Journal List > J Korean Acad Oral Health > v.43(4) > 1140759

Kim, Byon, Nam, Kim, and Jeong: In vitro fluoride release from five different fluoride varnishes

Abstract

Objectives

This study aims to compare the fluoride-release between different fluorine varnish under in vitro experimental conditions.

Methods

In this study, 5 fluoride varnish products distributed in Korea were selected. V-varnish™ (Vericom, Korea: VV), CavityShield™ (3M ESPE, USA: CS), Clinpro™ White varnish™ (3M ESPE, USA: CP), MI Varnish™ (GC, Japan: MI), and Fluor Protector (Ivoclar Vivadent, Liechtenstein: FP). For the in vitro study, 10 mg of each fluoride varnish was thinly applied to the same area of the specimen. The specimen was then immersed in 3 ml of distilled water at consistent intervals to confirm fluoride release. Nine specimens per group were used. Fluoride ion electrodes were used to measure the fluoride concentration of the solution. The Kruskal-Wallis nonparametric test was performed to compare between each experimental group, and the Wilcoxon signed-rank nonparametric test was performed to compare experimental groups over time. The significance level for a Type I error was set at 0.05. All statistical analyses were performed using SPSS 25.0 (IBM Co., Armonk, NY, USA).

Results

In vitro experiments showed that the amount of fluoride released from MI was higher than the other groups during the first 12 hours after application. However, the amount of fluoride released from CP and CS was higher than MI as the immersion time increased over 12 and 20 hours, respectively. The fluoride release from FP was the lowest at all measurement points.

Conclusions

The results of this study showed that the remaining fluoride effect from rosin type fluoride varnishes was higher than liquid type fluoride varnishes. There were differences in the residual fluoride concentrations despite each fluoride varnish having the same fluoride content.

Figures and Tables

Fig. 1

Fluoride release after 1 minute immersion over time (0–4 hours).

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Fig. 2

Fluoride release after 1 hour immersion over time (0–4 hours).

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Fig. 3

Four hour fluoride release from 4 to 20 hours.

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Table 1

Information on fluoride varnishes evaluated in this study

jkaoh-43-184-i001

*Difluorosilane: Bis {4-[2-(difluorohydroxysilyl)ethyl]-2-methoxycyclohexyl} [N,N-(trimethylhexan-1,6-diyl) dicarbamate]. Source from the Material Safety Data sheet (MSDS) of manufacturer. Source from the Ministry of Food and Drug Safety (MFDS), South Korea.

Table 2

Immersing process of fluoride varnish applied specimens

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Table 3

Fluoride release after 1 minute immersion over time (0–4 hours)

jkaoh-43-184-i003

Values are presented as mean (SD) of fluoride concentration (ppm). The time indicated the time after fluoride varnish application.

CS, CavityShield™; VV, V-varnish™ Premium clear; CP, Clinpro™ White varnish; MI, MI Varnish™; FP, Fluor Protector.

a,b,c,dData in column with the same letter are not significantly different.

Table 4

Fluoride release after 1 hour immersion over time (0–4 hours)

jkaoh-43-184-i004

Values are presented as mean (SD) of fluoride concentration (ppm). The time indicated the time after fluoride varnish application.

A/B ratio=0–1 hour/3–4 hour.

CS, CavityShield™; VV, V-varnish™ Premium clear; CP, Clinpro™ White varnish; MI, MI Varnish™; FP, Fluor Protector.

a,b,c,dData in column with the same letter are not significantly different.

Table 5

Four hour fluoride release from 4 to 20 hours

jkaoh-43-184-i005

Values are presented as mean (SD) of fluoride concentration (ppm). The time indicated the time after fluoride varnish application.

C/D ratio=4–8 hour/16–20 hour.

CS, CavityShield™; VV, V-varnish™ Premium clear; CP, Clinpro™ White varnish; MI, MI Varnish™; FP, Fluor Protector.

a,b,c,dData in column with the same letter are not significantly different. 1,2,3Data in row with the same number are not significantly different.

Notes

This work was supported by the (NRF) grant funded by the Korea government (MSIT) (No. 2019R1F1A1061836).

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TOOLS
ORCID iDs

Ji-Soo Kim
https://orcid.org/0000-0003-1571-4762

Min-Ji Byon
https://orcid.org/0000-0003-0359-9234

Yong-Tae Nam
https://orcid.org/0000-0002-2377-4151

Jin-Bom Kim
https://orcid.org/0000-0001-8619-2741

Seung-Hwa Jeong
https://orcid.org/0000-0001-5173-2859

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