Journal List > Korean Lepr Bull > v.52(1) > 1139957

Lee: Group-Based Cognitive Intervention for People Affected with Leprosy and Mild Cognitive Impairment: A Clinic Based Study

Abstract

Background

Mild cognitive impairment represents a cognitive state between the subject memory impairment and early dementia. Proper cognitive interventions at this period can delay its development into dementia. However, it is yet uncertain whether cognitive interventions for people affected with leprosy and mild cognitive impairment have beneficial effects.

Objectives

The purpose of this study was to investigate the efficacy of group-based cognitive intervention in people affected with leprosy and mild cognitive impairment.

Methods

We consecutively recruited the PALs who came to the neurology clinic in Sorokdo National Hospital form 2018 January to September complaining with cognitive decline. Of 25 patients who visited, 10 patients were diagnosed with MCI. 5 patients agreed to participate in structured group-based cognitive intervention (CogMCI) which was validated through nation-wide randomized clinical trial. For 12 weeks, subjects received CogMCI twice per week by a trained instructor. They were assessed with Seoul Neuropsychological Screening Battery-2 at baseline and postintervention. We performed Wilcoxon signed rank test to validate efficacy of the CogMCI program.

Results

In comparison to the baseline score, the subjects receiving CogMCI showed significant improvements in cognition at postintervention. Memory domain and Frontal/Executive function scores were significantly improved. K-Mini-Mental-Status-Examination was increased from 24.2 to 26.4 though not significant. K-Instrumental-Activity of Daily Living score was decreased from 0.32 to 0.18 and Short-term Geriatric Depression Scale was also decreased from 7.6 to 5.6.

Conclusions

CogMCI, the group-based cognitive intervention program, resulted in cognitive improvements, especially in memory and frontal/executive function domains in PALs with MCI. Further study is needed to assess the persistent effect of cognitive intervention program after it is discontinued.

Figures and Tables

Table 1

NIA-AA diagnostic guideline of Mild Cognitive Impairment

klb-52-17-i001
Table 2

Neuropsychiatric battery results of pre and post CogMCI intervention

klb-52-17-i002

References

1. Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV. Current concepts in mild cognitive impairment. Arch Neurol. 2001; 58:1985–1992.
crossref
2. Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S. Alzheimer's Disease Cooperative Study Group. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005; 352:2379–2238.
crossref
3. Cooper C, Li R, Lyketsos C, Livingston G. Treatment for mild cognitive impairment: systematic review. Br J Psychiatry. 2013; 203:255–264.
crossref
4. Paillard-Borg S, Fratiglioni L, Xu W, Winblad B, Wang HX. An active lifestyle postpones dementia onset by more than one year in very old adults. J Alzheimers Dis. 2012; 31:835–842.
crossref
5. Belleville S, Clement F, Mellah S, Gilbert B, Fontaine F, Gauthier S. Training-related brain plasticity in subjects at risk of developing Alzheimer's disease. Brain. 2011; 134:1623–1634.
crossref
6. Jeong JH, Na HR, Choi SH, Kim J, Na DL, Seo SW. Group- and Home-Based Cognitive Intervention for Patients with Mild Cognitive Impairment: A Randomized Controlled Trial. Psychother Psychosom. 2016; 85:198–207.
crossref
7. Lee M. Neuropsychiatric Characteristics of Mild Cognitive Impairment patients with history of Hansen's disease: Based on Seoul Neuropsychological Screening Battery-II. J Sorokdo Natl Hosp. 2019; 40:70–78.
8. Guo LH, Alexopoulos P, Eisele T, Wagenpfeil S, Kurz A, Perneczky R. The National Institute on Aging-Alzheimer's Association research criteria for mild cognitive impairment due to Alzheimer's disease: predicting the outcome. Eur Arch Psychiatry Clin Neurosci. 2013; 263:325–333.
crossref
9. Jean L, Bergeron ME, Thivierge S, Simard M. Cognitive intervention programs for individuals with mild cognitive impairment: systematic review of the literature. Am J Geriatr Psychiatry. 2010; 18:281–296.
crossref
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ORCID iDs

Min-woo Lee
https://orcid.org/0000-0001-8474-5744

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