Abstract
Purpose
This study aimed to examine the mediating role of physical activity in the relationship between depressive symptoms and health-related quality of life in patients with coronary artery disease.
Methods
A descriptive cross-sectional study design was conducted using the data from the 2016 Korea Community Health Survey. The participants comprised 6,072 patients with coronary artery disease aged 19 years or older. Depressive symptoms, physical activity, and health-related quality of life were assessed. The collected data were analyzed by a complex sample test using SPSS/WIN 24.0 program. Bootstrapping methodology was utilized to examine the mediating role of physical activity in the relationship between depressive symptoms and health-related quality of life with SPSS PROCESS macro Model 4.
Results
The results of the hierarchical linear regression analysis showed that depressive symptoms (t=−22.37, p<.001) and physical activity (t=12.12, p<.001) were significant predictor of health-related quality of life. A mediation analysis further revealed that physical activity mediates the relationship between depressive symptoms and health-related quality of life.
Conclusion
This study suggests that the negative impact of depressive symptoms on health-related quality of life can be improved through physical activity. Healthcare providers should consider these finding during early assessment of depressive symptoms in patients with coronary artery disease. Moreover, developing intervention strategies to enhance the level of physical activity could improve health-related quality of life of patients.
References
1. Statistics Korea. 2018 statistics of causes of death for Korea [Internet]. Seoul: Statistics Korea;2019. cited 2019 October 1. Available from: http://kostat.go.kr/portal/korea/kor_nw/1/6/2/index.board?bmode=read&aSeq=377606.
2. Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, et al. 2013 ESC guidelines on the management of stable coronary artery disease. European Heart Journal. 2013; 34(38):2949–3003. DOI: 10.1093/eurheartj/eht296.
3. Takematsu Y, Hasebe Y, Moriwaki Y, Kotera N, Yamada C, Nakagami T, et al. Evaluation of quality of life among patients with ischemic heart disease who practiced self-care activities at home after elective percutaneous coronary intervention. Cardiovascular Intervention and Therapeutics. 2015; 30(2):115–120. DOI: 10.1007/s12928-014-0294-0.
4. De Smedt D, Clays E, De Bacquer D. Measuring health-related quality of life in cardiac patients. European Heart Journal-Quality of Care and Clinical Outcomes. 2016; 2(3):149–150. DOI: 10.1093/ehjqcco/qcw015.
5. Seo J, Lee Y, Kang S, Chun H, Pyun WB, Park SH, et al. Poor health-related quality of life and proactive primary control strategy may act as risk factors for acute coronary syndrome. Korean Circulation Journal. 2015; 45(2):117–124. DOI: 10.4070/kcj.2015.45.2.117.
6. Lee HT, Shin J, Lim YH, Kim KS, Kim SG, Kim JH, et al. Health related quality of life in coronary heart disease in Korea: the Korea National Health and Nutrition Examination Survey 2007 to 2011. Angiology. 2015; 66(4):326–332. DOI: 10.1177/0003319714533182.
7. Batóg P, Rencz F, Péntek M, Gulácsi L, Filipiak KJ, Rupel VP, et al. EQ-5D studies in cardiovascular diseases in eight Central and Eastern European countries: a systematic review of the literature. Kardiologia Polska. 2018; 76(5):860–870. DOI: 10.5603/KP.a2018.0033.
8. Vaccarino V, Badimon L, Bremner JD, Cenko E, Cubedo J, Dorobantu M, et al. Depression and coronary heart disease: 2018 ESC position paper of the working group of coronary pathophysiology and microcirculation developed under the auspices of the ESC Committee for Practice Guidelines. European Heart Journal. 2019; DOI: 10.1093/eurheartj/ehy913. Forthcoming.
9. Sajobi TT, Wang M, Awosoga O, Santana M, Southern D, Liang Z, et al. Trajectories of health-related quality of life in coronary artery disease. Circ Cardiovasc Qual Outcomes. 2018; 11(3):e003661. DOI: 10.1161/CIRCOUTCOMES.117.003661.
10. Mastenbroek MH, Versteeg H, Zijlstra W, Meine M, Spertus JA, Pedersen SS. Disease-specific health status as a predictor of mortality in patients with heart failure: a systematic literature review and meta-analysis of prospective cohort studies. European Journal of Hheart Failure. 2014; 16(4):384–393. DOI: 10.1002/ejhf.55.
11. Ludt S, Wensing M, Szecsenyi J, Van Lieshout J, Rochon J, Freund T, et al. Predictors of health-related quality of life in patients at risk for cardiovascular disease in European primary care. PloS One. 2011; 6(12):>e29334. DOI: 10.1371/journal.pone.0029334.
12. Abdallah MS, Wang K, Magnuson EA, Spertus JA, Farkouh ME, Fuster V, et al. Quality of life after PCI vs CABG among patients with diabetes and multivessel coronary artery disease: a randomized clinical trial. JAMA. 2013; 310(15):1581–1590. DOI: 10.1001/jama.2013.279208.
13. Elderon L, Smolderen KG, Na B, Whooley MA. Accuracy and prognostic value of American Heart Association-recommended depression screening in patients with coronary heart disease: data from the heart and soul study. Cardiovascular Quality and Outcomes. 2011; 4(5):533–540. DOI: 10.1161/CIRCOUTCOMES.110.960302.
14. Buneviciute J, Staniute M, Brozaitiene J, Girdler SS, Bunevicius R. Mood symptoms and personality dimensions as determinants of health-related quality of life in patients with coronary artery disease. Journal of Health Psychology. 2013; 18(11):1493–1504. DOI: 10.1177/1359105312465909.
15. Dickens C, Cherrington A, McGowan L. Depression and healthrelated quality of life in people with coronary heart disease: a systematic review. European Journal of Cardiovascular Nursing. 2012; 11(3):265–275. DOI: 10.1177/1474515111430928.
16. Vaccarino V, Badimon L, Bremner JD, Cenko E, Cubedo J, Dorobantu M, et al. Depression and coronary heart disease: 2018 ESC position paper of the working group of coronary pathophysiology and microcirculation developed under the auspices of the ESC Committee for Practice Guidelines. European Heart Journal. 2019; Forthcoming. DOI: 10.1093/eurheartj/ehy913.
17. Wardoku R, Blair C, Demmer R, Prizment A. Association between physical inactivity and health-related quality of life in adults with coronary heart disease. Maturitas. 2019; 128:36–42. DOI: 10.1016/j.maturitas.2019.07.005.
18. Heiskanen J, Tolppanen AM, Roine RP, Hartikainen J, Hippeläinen M, Miettinen H, et al. Comparison of EQ-5D and 15D instruments for assessing the health-related quality of life in cardiac surgery patients. European Heart Journal-Quality of Care and Clinical Outcomes. 2016; 2(3):193–200. DOI: 10.1093/ehjqcco/qcw002.
19. Ludwig VM, Bayley A, Cook DG, Stahl D, Treasure JL, Asthworth M, et al. Association between depressive symptoms and objectively measured daily step count in individuals at high risk of cardiovascular disease in South London, UK: a crosssectional study. BMJ open. 2018; 8(4):e020942.
20. Korea Centers for Disease Control and Prevention. Community health survey [Internet]. Cheongju: Korea Centers for Disease Control and Prevention;2016. cited 2019 September 10. Available from: https://chs.cdc.go.kr/chs/mnl/mnlBoardMain.do.
21. Kim S, Kim Y, Kwon H. Differences in health related quality of life by sleep duration and subjective oral health in Korean adults with coronary artery disease. International Journal of Nursing Practice. 2017; 23(2):e12515. DOI: 10.1111/ijn.12515.
22. Kwok CS, Kontopantelis E, Kuligowski G, Gray M, Muhyaldeen A, Gale C, et al. Self reported sleep duration and quality and cardiovascular disease and mortality: a dose response meta analysis. Journal of the American Heart Association. 2018; 7(15):e008552. DOI: 10.1161/JAHA.118.008552.
23. Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Medicine and Science in Sports and Exercise. 2003; 35(8):1381–1395. DOI: 10.1249/01.mss.0000078924.61453.fb.
24. Oh JY, Yang YJ, Kim BS, Kang JH. Validity and reliability of Korean version of International Physical Activity Questionnaire (IPAQ) short form. Journal of the Korean Academy of Family Medicine. 2007; 28(7):532–541.
25. The EuroQol Group. EuroQol-a new facility for the measurement of health-related quality of life. Health Policy. 1990; 16(3):199–208. DOI: 10.1016/0168-8510(90)90421-9.
26. Lee SI. Validity and reliability evaluation for EQ-5D in Korea. Seoul: Korea Centers for Disease Control and Prevention;2011. p. 1–106.
27. Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology. 1986; 51(6):1173–1182. DOI: 10.1037/0022-3514.51.6.1173.
28. Hayes AF. Introduction to mediation, moderation, and conditional process analysis: a regression-based approach. 2nd ed. New York: The Guilford Press;2018. p. 167–180.
29. Bae BR. Structural equation modeling with Amos 21: principles and practice. Seoul: Cheong-Ram Publishing;2014. p. 424–444.
30. Peterson JC, Charlson ME, Wells MT, Altemus M. Depression, coronary artery disease, and physical activity: how much exercise is enough? Clinical Therapeutics. 2014; 36(11):1518–1530. DOI: 10.1016/j.clinthera.2014.10.003.
31. Lichtman JH, Froelicher ES, Blumenthal JA, Carney RM, Doering LV, Frasure-Smith , et al. Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: systematic review and recommendations: a scientific statement from the American Heart Association. Circulation. 2014; 129(12):1350–1369. DOI: 10.1161/CIR.0000000000000019.
32. Gan Y, Gong Y, Tong X, Sun H, Cong Y, Dong X, et al. Depression and the risk of coronary heart disease: a meta-analysis of prospective cohort studies. BMC psychiatry. 2014; 14:371. DOI: 10.1186/s12888-014-0371-z.
33. Burg MM, Meadows J, Shimbo D, Davidson KW, Schwartz JE, Soufer R. Confluence of depression and acute psychological stress among patients with stable coronary heart disease: effects on myocardial perfusion. Journal of the American Heart Association. 2014; 3(6):e000898. DOI: 10.1161/JAHA.114.000898.
34. Won MH, Son YJ. Perceived social support and physical activity among patients with coronary artery disease. Western Journal of Nursing Research. 2017; 39(12):1606–1623. DOI: 10.1177/0193945916678374.
35. Buneviciute J, Staniute M, Brozaitiene J, Girdler SS, Bunevicius R. Mood symptoms and personality dimensions as determinants of health-related quality of life in patients with coronary artery disease. Journal of Health Psychology. 2013; 18(11):1493–1504. DOI: 10.1177/1359105312465909.